RESUMEN
OBJECTIVES: Gingival phenotype is decisive in periodontal health, aesthetics, and function and is a predictor of treatment outcomes. Injectable platelet-rich fibrin is a recently proposed method of gingival augmentation due to its enhanced regenerative potential. The objective of the present study was to evaluate the efficacy of injectable platelet-rich fibrin for gingival phenotype modification. MATERIALS AND METHODS: In this split-mouth study, 30 healthy volunteers with thin gingival biotypes in either maxillary or mandibular incisors were included. iPRF was prepared using 64 g relative centrifugal force for 3 min. i-PRF was injected into the attached gingiva using a 27-gauge disposable needle in relation to the test sites (n = 360), and contralateral sites were kept as control. Re-evaluation was done at the end of 3 and 6 months. Post-operative complications and patient-reported experience measures were also recorded. Statistical analysis was done using paired t-test and analysis of covariance. RESULTS: Statistically significant increase in gingival thickness was found in the test group at the individual site and tooth level. An overall increase in gingival thickness of 26.56% after 3 months and 29% after 6 months compared to baseline was noticed in the test group. No significant difference was found in the width of keratinized gingiva in any of the comparisons. CONCLUSION: The non-surgical application of i-PRF is promising for enhancing gingival thickness. Future well-controlled studies with long-term follow-up in different patient populations can provide more evidence. CLINICAL RELEVANCE: Gingival phenotype modification is a useful therapy to prevent the occurrence of gingival recession in patients with thin phenotypes. TRIAL REGISTRATION: Clinical Trial Registration Number: CTRI/2021/04/032650.