Performance of European prediction models for classification of type 1 and type 2 diabetes in Indians.

AIM: We aimed to determine the performance of European prediction models in an Indian population to classify type 1 diabetes(T1D) and type 2 diabetes(T2D). METHODS: We assessed discrimination and calibration of published models of diabetes classification, using retrospective data from electronic medical records of 83309 participants aged 18-50 years living in India. Diabetes type was defined based on C-peptide measurement and early insulin requirement. Models assessed combinations of clinical measurements: age at diagnosis, body mass index(mean = 26.6 kg/m2), sex(male = 64.9 %), Glutamic acid decarboxylase(GAD) antibody, serum cholesterol, serum triglycerides, and high-density lipoprotein(HDL) cholesterol. RESULTS: 67955 participants met inclusion criteria, of whom 0.8 % had T1D, which was markedly lower than model development cohorts. Model discrimination for clinical features was broadly similar in our Indian cohort compared to the European cohort: area under the receiver operating characteristic curve(AUC ROC) was 0.90 vs. 0.90 respectively, but was lower in the subset of young participants with measured GAD antibodies(n = 2404): and an AUC ROC of 0.87 when clinical features, sex, lipids and GAD antibodies were combined. All models substantially overestimated the likelihood of T1D, reflecting the lower prevalence of T1D in the Indian population. However, good model performance was achieved after recalibration by updating the model intercept and slope. CONCLUSION: Models for diabetes classification maintain the discrimination of T1D and T2D in this Indian population, where T2D is far more common, but require recalibration to obtain appropriate model probabilities. External validation and recalibration are needed before these tools can be used in non-European populations.

Topic modeling and social network analysis approach to explore diabetes discourse on Twitter in India.

Introduction: The utilization of social media presents a promising avenue for the prevention and management of diabetes. To effectively cater to the diabetes-related knowledge, support, and intervention needs of the community, it is imperative to attain a deeper understanding of the extent and content of discussions pertaining to this health issue. This study aims to assess and compare various topic modeling techniques to determine the most effective model for identifying the core themes in diabetes-related tweets, the sources responsible for disseminating this information, the reach of these themes, and the influential individuals within the Twitter community in India. Methods: Twitter messages from India, dated between 7 November 2022 and 28 February 2023, were collected using the Twitter API. The unsupervised machine learning topic models, namely, Latent Dirichlet Allocation (LDA), non-negative matrix factorization (NMF), BERTopic, and Top2Vec, were compared, and the best-performing model was used to identify common diabetes-related topics. Influential users were identified through social network analysis. Results: The NMF model outperformed the LDA model, whereas BERTopic performed better than Top2Vec. Diabetes-related conversations revolved around eight topics, namely, promotion, management, drug and personal story, consequences, risk factors and research, raising awareness and providing support, diet, and opinion and lifestyle changes. The influential nodes identified were mainly health professionals and healthcare organizations. Discussion: The study identified important topics of discussion along with health professionals and healthcare organizations involved in sharing diabetes-related information with the public. Collaborations among influential healthcare organizations, health professionals, and the government can foster awareness and prevent noncommunicable diseases.

Detection of hotspots of school dropouts in India: A spatial clustering approach.

School dropout is a significant concern universally. This paper investigates the incorporation of spatial dependency in estimating the topographical effect of school dropout rates in India. This study utilizes the secondary data on primary, upper primary, and secondary school dropout rates of the different districts of India available at the Unified District Information System for Education plus (UDISE+) for the year 2020 to contemplate the impact of these dropouts from one region to different regions in molding with promotion rate and repetition rate. The Global Moran's I, Univariate and Bivariate Local Indicators of Spatial Association, and spatial models are utilized to investigate the geographical variability and to find the possible relationship between dropout rates and the school-level factors at the district level. The outcomes provide clear spatial clustering and precisely highlight the hot zone dropout regions with high repetition and low promotion rates. Based on this study's results, educational administrators can make evidence-based decisions to reduce dropout rates in hot zones of various regions of India. Furthermore, futuristic studies focusing on linking spatial hot zones with causal factors will add consistent data in assisting policymakers in taking necessary measures to develop a sound education management system.

Social media analytics and reachability evaluation - #Diabetes.

BACKGROUND AND AIMS: Diabetes as a lifestyle disorder could be effectively managed by creating awareness among people through social media. Understanding the content of Twitter messages will aid in strategizing health communication about diabetes to the community through Twitter. This study aimed to analyze the content, sentiment, and reachability of diabetes related tweets posted in India. METHODS: Diabetes related messages from India were collected via Twitter's Application Programming Interface for April 2019. Themes and subthemes of tweet content were identified from randomly selected tweets. The tweets were coded as the source, themes, and subthemes manually. Sentiment analysis of the tweets was done by a lexicon-based approach. The reachability of tweets was assessed based on re-tweet and favorite counts. RESULTS: Out of 1840 tweets, 57.28% were from organizations and 42.72% were from individuals. The largest proportion of tweet messages were informative (50.76%), followed by promotional tweets (21.52%). The largest proportion of tweets were positive (40.4%) followed by neutral (31.14%) tweets. Among the six major themes, the diabetes story had the highest reachability. CONCLUSIONS: The outcome of this study would aid public health professionals in planning information dissemination and communication regarding diabetes on Twitter so that the right information reaches a wider population.

Use of social media data for disease based social network analysis and network modeling: A Systematic Review.

Burden due to infectious and noncommunicable disease is increasing at an alarming rate. Social media usage is growing rapidly and has become the new norm of communication. It is imperative to examine what is being discussed in the social media about diseases or conditions and the characteristics of the network of people involved in discussion. The objective is to assess the tools and techniques used to study social media disease networks using network analysis and network modeling. PubMed and IEEEXplore were searched from 2009 to 2020 and included 30 studies after screening and analysis. Twitter, QuitNet, and disease-specific online forums were widely used to study communications on various health conditions. Most of the studies have performed content analysis and network analysis, whereas network modeling has been done in six studies. Posts on cancer, COVID-19, and smoking have been widely studied. Tools and techniques used for network analysis are listed. Health-related social media data can be leveraged for network analysis. Network modeling technique would help to identify the structural factors associated with the affiliation of the disease networks, which is scarcely utilized. This will help public health professionals to tailor targeted interventions.

Spatio-temporal distribution of negative emotions on Twitter during floods in Chennai, India, in 2015: a post hoc analysis.

BACKGROUND: Natural disasters are known to take their psychological toll immediately, and over the long term, on those living through them. Messages posted on Twitter provide an insight into the state of mind of citizens affected by such disasters and provide useful data on the emotional impact on groups of people. In 2015, Chennai, the capital city of Tamil Nadu state in southern India, experienced unprecedented flooding, which subsequently triggered economic losses and had considerable psychological impact on citizens. The objectives of this study are to (i) mine posts to Twitter to extract negative emotions of those posting tweets before, during and after the floods; (ii) examine the spatial and temporal variations of negative emotions across Chennai city via tweets; and (iii) analyse associations in the posts between the emotions observed before, during and after the disaster. METHODS: Using Twitter's application programming interface, tweets posted at the time of floods were aggregated for detailed categorisation and analysis. The different emotions were extracted and classified by using the National Research Council emotion lexicon. Both an analysis of variance (ANOVA) and mixed-effect analysis were performed to assess the temporal variations in negative emotion rates. Global and local Moran's I statistic were used to understand the spatial distribution and clusters of negative emotions across the Chennai region. Spatial regression was used to analyse over time the association in negative emotion rates from the tweets. RESULTS: In the 5696 tweets analysed around the time of the floods, negative emotions were in evidence 17.02% before, 29.45% during and 11.39% after the floods. The rates of negative emotions showed significant variation between tweets sent before, during and after the disaster. Negative emotions were highest at the time of disaster's peak and reduced considerably post disaster in all wards of Chennai. Spatial clusters of wards with high negative emotion rates were identified. CONCLUSIONS: Spatial analysis of emotions expressed on Twitter during disasters helps to identify geographic areas with high negative emotions and areas needing immediate emotional support. Analysing emotions temporally provides insight into early identification of mental health issues, and their consequences, for those affected by disasters.