Cavity shaving for invasive breast cancer conservative surgery: Reduced specimen volume and margin positive rates.

INTRODUCTION: The cavity shaving (CS) technique was described in breast conserving surgery to reduce the rate of reoperation avoiding the need for intraoperative margin analysis. This study assesses differences in the rates of involvement of the surgical margin (requiring further surgery) and volume of surgical specimens, depending on the use or not of this technique. MATERIAL AND METHODS: A retrospective cohort study was conducted in patients with breast carcinoma who underwent breast conserving surgery between 2013 and 2019. They were divided into two groups depending on whether the cavity shaving technique was used or not. Primary outcomes of the study included presence of final margin involvement, requiring need for further surgery, and the volume of excised tissue comparing the study groups. RESULTS: A total of 202 cases were included: 92 in the control group and 110 in the cavity shaving group. Significant differences were found regarding involvement of the final margin (19.57% control group vs. 4.55% cavity shaving group; p = 0.010). The volume of additional surgical specimens were significantly greater in the traditional technique group than in the shaving technique (46.43 vs 13.32 cm3; p = 0.01) as was total specimen volume (143.40 vs 100.63 cm3; p = 0.022). CONCLUSIONS: CS can reduce the positive margin and re-excision rates without larger-volume resections and should therefore be considered a routine technique in BCS for early-stage breast cancer.

Is the result of breast Tc-99m mibi scintigraphy a prognostic factor for survival in invasive breast cancer? / ¿Es el resultado de la gammagrafía con Tc-99m MIBI un factor pronóstico para la supervivencia en el cáncer invasor de mama?

Background Breast scintigraphy with Tc-99m MIBI showed utility in diagnosing and monitoring response to neoadjuvant treatment. This work studies if there are differences in long-term survival in breast carcinomas depending on the result of Tc-99 MIBI scintigraphy and to analyze their relationship with other variables of prognostic value. Material and methods A prospective observational study on a series of cases of breast cancer in which scintigraphy with Tc-99m MIBI was carried out prior to its treatment, and which had a minimum follow-up of ten years. Clinical–epidemiological, histopathological and immunohistochemical variables were recorded. Bivariate and multivariate analysis were performed studying the result of Tc99m-MIBI scintigraphy. Differences in OS and DFS were studied using Kaplan Meier curves with the log-rank test between factors. Results The significant relationship was found between Tc-99m-MIBI positive result and palpable tumors (p=0.0001), poorly differentiated (p=0.003), with lymph node involvement (p=0.038) and high cell proliferation (p=0.007), although only the palpability and tumor size are related after multivariate analysis. Patients with Tc-99m MIBI positive tumors showed a worse OS (p=0.043) and DFS (p=0.026), independently of size and palpability of the lesión. Conclusion Tc-99m MIBI scintigraphy showed prognostic importance in invasive breast cancer, relating its positivity to reduced long-term survival. (AU)

Introducción La gammagrafía mamaria con Tc-99m MIBI ha mostrado su utilidad en el diagnóstico y la monitorización de la respuesta al tratamiento neoadyuvante. Este trabajo estudia si hay diferencias en la supervivencia por cáncer de mama a largo plazo dependiendo del resultado de la gammagrafía con Tc-99m MIBI y analizar su relación con otras variables de valor pronóstico. Material y métodos Se realizó un estudio observacional prospectivo sobre una serie de pacientes con cáncer de mama en las que se realizó una gammagrafía con Tc-99m MIBI previa a su tratamiento, y con un seguimiento mínimo de 10 años. Se registraron variables clínico-epidemiológicas, histopatológicas e inmunohistoquímicas. Se realizaron análisis bivariante y multivariante para el resultado de la gammagrafía con Tc-99m MIBI. Se estudiaron la supervivencia glogal y libre de enfermedad mediante la curva de Kaplan-Meier y el test de log-rank entre factores. Resultados Se encontró una relación significativa entre la gammagrafía con Tc-99m MIBI positiva y las lesiones palpables (p=0,0001), pobremente diferenciadas (p=0,003), con afectación ganglionar (p=0,038) y alta proliferación celular (p=0,007), aunque solo la palpabilidad y el tamaño tumoral fueron significativos en el análisis multivariante. Las pacientes con gammagrafía positiva mostraron peor supervivencia global (p=0,043) y libre de enfermedad (p=0,026), independientemente del tamaño o la palpabilidad de la lesión. Conclusión La gammagrafía mamaria con Tc-99m MIBI presenta una relevancia pronóstica en cáncer invasor de mama, relacionando su positividad con menor supervivencia a largo plazo. (AU)

Reflexiones y evidencias sobre la mastectomía reductora de riesgo / Risk reducing mastectomy: reflections and evidences

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Carcinoma neuroendocrino primario de mama / Primary neuroendocrine carcinoma of the breast

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Mastitis granulomatosa idiopática. Una rara entidad benigna que puede simular un cáncer de mama / Idiopathic granulomatous mastitis. A rare benign entitiy that can simulate breast cancer

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Effectiveness of arterial embolization in recurrent bleeding due to duodenal ulcer during postoperative cardiac surgery.

Upper gastrointestinal bleeding is one of the most frequent complications after cardiac surgery and endoscopic treatment (ET) is often the first-choice procedure. When it fails, surgery can be an option but has significant mortality and morbidity. We propose arterial embolization (TAE: transcatheter arterial embolization) as an alternative treatment in selected cases.

Efectividad de la embolización arterial en el manejo de la hemorragia recurrente por ulcus duodenal en el postoperatorio de cirugía cardiaca / Effectiveness of arterial embolization in recurrent bleeding due to duodenal ulcer during postoperative cardiac surgery

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Resección hepática por laparoscopia: lecciones aprendidas tras 132 resecciones / Laparoscopic liver resection: lessons learned after 132 resections

Introducción Tras 20 años de experiencia en cirugía hepática laparoscópica, aún no están bien definidos el mejor abordaje (totalmente laparoscópico [CTL] o asistido con la mano [CLA]), indicaciones quirúrgicas, posición, instrumentación, resultados postoperatorios inmediatos y a largo plazo, etc. Objetivo Presentar nuestra experiencia en resecciones hepáticas laparoscópicas (RHL).Pacientes y método En 10 años hemos realizado 132 RHL en 129 pacientes: 112 tumores malignos (90 metástasis hepáticas; 22 tumores malignos primarios) y 20 lesiones benignas (18 tumores benignos; 2 quistes hidatídicos). Veintiocho casos se realizaron por CTL y 104 por CLA. Técnica quirúrgica: 6 hepatectomías derechas (2 como segundo tiempo de una resección hepática en 2 tiempos); 6 hepatectomías izquierdas; 9 resecciones de 3 segmentos; 42 resecciones de 2 segmentos; 64 resecciones de un segmento y 5 casos de resecciones locales. Resultados No existió mortalidad perioperatoria. Morbilidad: 3%. Con CTL se completó la resección en 23/28 casos, mientras que con CLA se completó en los 104 casos. Transfusión 4,5%; tiempo quirúrgico 150 min y estancia media de 3,5 días. La supervivencia a 1, 3 y 5 años de los tumores malignos primarios fue del 100, 86 y 62%, mientras que la supervivencia de las metástasis colorrectales fue del 92, 82 y 52%, respectivamente. Conclusión La RHL, tanto por CTL como por CLA, en casos seleccionados, reproduce los resultados de la cirugía abierta (morbimortalidad y supervivencia a 5 años similares), con las ventajas de la cirugía mínimamente invasiva (AU)

Introduction After 20 years of experience in laparoscopic liver surgery there is still no clear definition of the best approach (totally laparoscopic [TLS] or hand-assisted [HAS]), the indications for surgery, position, instrumentation, immediate and long-term postoperative results, etc. Aim To report our experience in laparoscopic liver resections (LLRs).Patients and method Over a period of 10 years we performed 132 LLRs in 129 patients: 112 malignant tumours (90 hepatic metastases; 22 primary malignant tumours) and 20 benign lesions (18 benign tumours; 2 hydatid cysts). Twenty-eight cases received TLS and 104 had HAS. Surgical technique: 6 right hepatectomies (2 as the second stage of a two-stage liver resection); 6 left hepatectomies; 9 resections of 3 segments; 42 resections of 2 segments; 64 resections of one segment; and 5 cases of local resections. Results There was no perioperative mortality, and morbidity was 3%. With TLS the resection was completed in 23/28 cases, whereas with HAS it was completed in all 104 cases. Transfusion: 4,5%; operating time: 150 min; and mean length of stay: 3,5 days. The 1-, 3- and 5-year survival rates for the primary malignant tumours were 100, 86 and 62%, and for colorectal metastases 92, 82 and 52%, respectively. Conclusion LLR via both TLS and HAS in selected cases are similar to the results of open surgery (similar 5-year morbidity, mortality and survival rates) but with the advantages of minimally invasive surgery (AU)

[Laparoscopic liver resection: lessons learned after 132 resections]. / Resección hepática por laparoscopia: lecciones aprendidas tras 132 resecciones.

INTRODUCTION: After 20 years of experience in laparoscopic liver surgery there is still no clear definition of the best approach (totally laparoscopic [TLS] or hand-assisted [HAS]), the indications for surgery, position, instrumentation, immediate and long-term postoperative results, etc. AIM: To report our experience in laparoscopic liver resections (LLRs). PATIENTS AND METHOD: Over a period of 10 years we performed 132 LLRs in 129 patients: 112 malignant tumours (90 hepatic metastases; 22 primary malignant tumours) and 20 benign lesions (18 benign tumours; 2 hydatid cysts). Twenty-eight cases received TLS and 104 had HAS. SURGICAL TECHNIQUE: 6 right hepatectomies (2 as the second stage of a two-stage liver resection); 6 left hepatectomies; 9 resections of 3 segments; 42 resections of 2 segments; 64 resections of one segment; and 5 cases of local resections. RESULTS: There was no perioperative mortality, and morbidity was 3%. With TLS the resection was completed in 23/28 cases, whereas with HAS it was completed in all 104 cases. Transfusion: 4,5%; operating time: 150min; and mean length of stay: 3,5 days. The 1-, 3- and 5-year survival rates for the primary malignant tumours were 100, 86 and 62%, and for colorectal metastases 92, 82 and 52%, respectively. CONCLUSION: LLR via both TLS and HAS in selected cases are similar to the results of open surgery (similar 5-year morbidity, mortality and survival rates) but with the advantages of minimally invasive surgery.

Una nueva estrategia quirúrgica para metástasis hepáticas bilobares múltiples: oclusión portal derecha y torniquete en la línea de sección parenquimatosa / A new surgical strategy for multiple multiple bilobular liver metastases: right portal occlusion and torniquet in the parenchyma section line

Recientemente, han publicado la oclusión portal derecha más split in situ como un nuevo método para hipertrofiar en 7 días el volumen residual (VR) tras las resecciones hepáticas en dos tiempos. Es una técnica compleja, fundamentada en ocluir las colaterales intrahepáticas entre ambos lóbulos. Presentamos una técnica original para hipertrofiar el VR ocluyendo la vena porta derecha y las colaterales intrahepáticas: mujer de 35 años con un tumor estromal intestinal y 14 metástasis bilobares, siendo el VR estimado del 24%. Una vez extirpadas las lesiones del lóbulo izquierdo, ocluimos la porta derecha y aplicamos un torniquete en la línea de Cantlie mediante maniobra de hanging. Al 7.° día hipertrofió el VR un 57% y al 8.° día se realizó una hepatectomía derecha. Nuestra técnica es eficaz y sencilla de realizar y, de corroborarse en futuros estudios, esta técnica sería de elección en las resecciones hepáticas en 2 tiempos (AU)

Right portal vein occlusion plus «in situ split» has recently been reported as a new method to hypertrophy the functional remnant volume (FRV) in 7 days after two-stage liver resection. It is a complex procedure associated with the occlusion of the intrahepatic collaterals between both lobes. We present an original technique for hypertrophying the FRV by occluding the right portal vein and the intrahepatic collaterals: a case is presented of a 35-year-old woman with an intestinal stromal tumour, 14 bilobar metastases and an estimated 24% FRV. Once the lesions were removed from the left lobe, we performed a right portal vein transection and applied a tourniquet on the Cantlie line, using the hanging manoeuvre. A 57% hypertrophy of the FRV was achieved by day 7, and the right hepatectomy was performed on day 8. Our technique is effective and simple to perform and if corroborated in future studies, this technique would be of choice in 2-stage liver resection (AU)

Hemorragia diferida de la arteria hepática derecha tras iatrogenia biliar por colecistectomía laparoscópica que precisó trasplante hepático por insuficiencia hepática aguda: caso clínico y revisión de la literatura / Delayed Right Hepatic Artery Haemorrhage After Iatrogenic Gallbladder by Laparoscopic Cholecystectomy that Required a Liver Transplant Due to Acute Liver Failure: Clinical Case and Review of the Literature

Introducción La lesión de la arteria hepática derecha (AHD) tras colecistectomía laparoscópica (CL) puede pasar desapercibida clínicamente, aunque a veces ocasiona una necrosis del lóbulo derecho. En situaciones excepcionales, cuando la necrosis se extiende al segmento IV, podría ocurrir un fallo hepático fulminante (FHF) y requerir un trasplante hepático urgente (TH).Pacientes y método Presentamos una revisión de la literatura médica de los pacientes en los que se indicó TH debido a una lesión vascular secundaria a lesión biliar por CL. También presentamos el cuarto paciente descrito en la literatura especializada que precisó TH secundario a lesión de la AHD tras CL, el segundo por FHF. Resultados El TH debido a la lesión de la AHD se realizó en 3 de 13 pacientes recogidos en la literatura médica: uno se realizó a los 3 meses de la lesión por FHF, tras realizar una hepatectomía derecha ampliada y los otros 2 debido a cirrosis biliar secundaria. Nuestro paciente se trasplantó a los 15 días de la lesión por FHF. Conclusiones La lesión de la AHD tras CL puede requerir TH por FHF, aunque es excepcional, es necesario pensar en esta posibilidad ante complicaciones de la AHD que requieran su oclusión (AU)

Introduction Right hepatic artery (RHA) injury after laparoscopic cholecystectomy (LC) may go unnoticed clinically, but can sometimes cause necrosis of the right lobe. Exceptionally, when the necrosis spreads to segment IV, fulminant liver failure (FLF) may occur, and an urgent liver transplantation (LT) may be required. Patients and method We provide a review of the literature on patients with indication for an LT due to vascular damage caused by bile duct injury following LC. The case reported herein is the fourth described in the specialized literature of LT due to RHA injury after LC and the second of FLF after RHA injury. Results LT due to RHA injury was performed in 3 of 13 patients reported in the literature: one LT was performed at 3 months due to FLF, after an extended right hepatectomy was performed, and the remaining two were performed due to secondary biliary cirrhosis. Our patient was transplanted due to FLF 15 days after the injury. Conclusions RHA injury after LC may require LT due to FLF. Although exceptional, this possibility should be considered when there are RHA complications that may require occlusion (AU)

[Delayed right hepatic artery haemorrhage after iatrogenic gallbladder by laparoscopic cholecystectomy that required a liver transplant due to acute liver failure: clinical case and review of the literature]. / Hemorragia diferida de la arteria hepática derecha tras iatrogenia biliar por colecistectomía laparoscópica que precisó trasplante hepático por insuficiencia hepática aguda: caso clínico y revisión de la literatura.

INTRODUCTION: Right hepatic artery (RHA) injury after laparoscopic cholecystectomy (LC) may go unnoticed clinically, but can sometimes cause necrosis of the right lobe. Exceptionally, when the necrosis spreads to segment IV, fulminant liver failure (FLF) may occur, and an urgent liver transplantation (LT) may be required. PATIENTS AND METHOD: We provide a review of the literature on patients with indication for an LT due to vascular damage caused by bile duct injury following LC. The case reported herein is the fourth described in the specialized literature of LT due to RHA injury after LC and the second of FLF after RHA injury. RESULTS: LT due to RHA injury was performed in 3 of 13 patients reported in the literature: one LT was performed at 3 months due to FLF, after an extended right hepatectomy was performed, and the remaining two were performed due to secondary biliary cirrhosis. Our patient was transplanted due to FLF 15 days after the injury. CONCLUSIONS: RHA injury after LC may require LT due to FLF. Although exceptional, this possibility should be considered when there are RHA complications that may require occlusion.

Adenomatosis hepática múltiple tratada con resección quirúrgica y radiofrecuencia / Multiple liver adenomatosis treated with surgical resection and radiofrequency

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La resección laparoscópica de los segmentos del lóbulo hepático izquierdo debe ser el abordaje inicial en centros con experiencia / Laparoscopic resection of the left segments of the liver: the ¿ideal technique¿ in experienced centres?

Introducción: La resección de tumores hepáticos del lóbulo izquierdo anatómico suele ser una técnica sencilla, tanto la seccionectomía lateral izquierda (SLI) como la segmentectomía II ó III. Nuestro objetivo es presentar los resultados del abordaje laparoscópico y plantear si podría ser el ¿técnica ideal¿ en las unidades de cirugía hepática con experiencia en cirugía hepática laparoscópica (CHL). Pacientes y método: Presentamos 18 pacientes con resección de tumores sólidos del lóbulo izquierdo anatómico por CHL: 10 casos con SLI y 8 casos con segmentectomía II ó III. Realizamos un estudio comparativo con un grupo control de 18 pacientes intervenidos con la misma técnica quirúrgica por cirugía abierta. Resultados: No hubo mortalidad en ninguno de los 2 grupos (n=36). La morbilidad fue similar (5.5% por grupo). Para la SLI, el grupo CHL (n=10) presentó menor estancia hospitalaria (p=0.005) y menor tiempo quirúrgico (141 vs 159min) (diferencias no e.s), que el grupo de CA. Para las resecciones segmentarias II ó III, el grupo CHL (n=8) presentó mayor empleo de la maniobra de Pringle (p=0.05), mayor tiempo quirúrgico (p=0.05) y una estancia hospitalaria inferior (4.8 vs 5.6 días) (diferencias no e.s), que el grupo de CA. Conclusiones: La SLI debe realizarse por laparoscopia en centros que tengan experiencia debido a una menor estancia hospitalaria y un menor tiempo quirúrgico que la realizada por CA, con la misma morbimortalidad. Las resecciones segmentarias II ó III realizadas por laparoscopia, aunque tienen menor estancia hospitalaria, presentan un mayor tiempo quirúrgico, por lo que las ventajas no son tan evidentes como para la SLI (AU)

Introduction: The resection of tumours of the anatomical left lobe is normally straightforward using either left lateral sectionectomy (LLSEC) or segmentectomy II or III. Our objective is to present the results of the laparoscopic approach and to consider whether this could be the ¿ideal technique¿ in liver surgery units where the surgeons have experience of laparoscopic liver surgery (LLSURG). Patients and methods: We have studied patients with resected solid tumours of the anatomical left lobe using LLSURG (n=18): 10 cases with LLSEC and 8 cases with segmentectomy II or III. We carried out a comparative study with a control group of 18 patients operated on using the same surgical technique using open surgery (OS). Results: There were no cases of mortality in either of the 2 groups (n=36). Morbidity was similar (5.5% per group). For LLSEC, the LLSURG group (n=10) had a shorter hospital stay (p=0.005) and less surgical time (141 vs. 159min) (differences not significant.), than the OS group. For segmentary resections II or III, in the LLSURG group (n=8) there was greater use of the Pringle manoeuvre (p=0.05), greater surgical time (p=0.05) and a shorter hospital stay (4.8 vs. 5.6 days) (differences not significant), than in the OS group. Conclusions: LLSEC should be carried out by laparoscopy in centres where they have considerable experience. The patients may have a shorter hospital stay and spend less time in surgery than when OS is performed, with the same morbidity and mortality rates. Segmentectomy resections II or III carried out by laparoscopy involve a shorter hospital stay but longer surgery time and therefore the advantages are not as evident as they are for LLSEC (AU)

[Laparoscopic resection of the left segments of the liver: the "ideal technique" in experienced centres?]. / La resección laparoscópica de los segmentos del lóbulo hepático izquierdo debe ser el abordaje inicial en centros con experiencia.

INTRODUCTION: The resection of tumours of the anatomical left lobe is normally straightforward using either left lateral sectionectomy (LLSEC) or segmentectomy II or III. Our objective is to present the results of the laparoscopic approach and to consider whether this could be the "ideal technique" in liver surgery units where the surgeons have experience of laparoscopic liver surgery (LLSURG). PATIENTS AND METHODS: We have studied patients with resected solid tumours of the anatomical left lobe using LLSURG (n=18): 10 cases with LLSEC and 8 cases with segmentectomy II or III. We carried out a comparative study with a control group of 18 patients operated on using the same surgical technique using open surgery (OS). RESULTS: There were no cases of mortality in either of the 2 groups (n=36). Morbidity was similar (5.5% per group). For LLSEC, the LLSURG group (n=10) had a shorter hospital stay (p=0.005) and less surgical time (141 vs. 159 min) (differences not significant.), than the OS group. For segmentary resections II or III, in the LLSURG group (n=8) there was greater use of the Pringle manoeuvre (p=0.05), greater surgical time (p=0.05) and a shorter hospital stay (4.8 vs. 5.6 days) (differences not significant), than in the OS group. CONCLUSIONS: LLSEC should be carried out by laparoscopy in centres where they have considerable experience. The patients may have a shorter hospital stay and spend less time in surgery than when OS is performed, with the same morbidity and mortality rates. Segmentectomy resections II or III carried out by laparoscopy involve a shorter hospital stay but longer surgery time and therefore the advantages are not as evident as they are for LLSEC.