RESUMEN
Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-ß-lactamase bla NDM-1, the extended-spectrum ß-lactamase bla PER-1, and the rare 16S methyltransferase rmtB2.
Asunto(s)
Antibacterianos/farmacología , COVID-19/terapia , Farmacorresistencia Bacteriana , Infecciones por Enterobacteriaceae/mortalidad , Neumonía Asociada al Ventilador/mortalidad , Providencia/efectos de los fármacos , Anciano , COVID-19/complicaciones , Infecciones por Enterobacteriaceae/sangre , Infecciones por Enterobacteriaceae/etiología , Infecciones por Enterobacteriaceae/microbiología , Oxigenación por Membrana Extracorpórea , Resultado Fatal , Humanos , Masculino , Pruebas de Sensibilidad Microbiana , Neumonía Asociada al Ventilador/etiología , Neumonía Asociada al Ventilador/microbiología , Providencia/genética , Providencia/aislamiento & purificaciónRESUMEN
Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management.
RESUMEN
Many cases of cutaneous vasculitis are drug-induced with histology revealing leukocytoclastic vasculitis (LCV). We present a case of levofloxacin-associated LCV successfully treated with prednisone and cessation of the offending drug. Although case reports describe a link between LCV and older fluoroquinolones, such as ciprofloxacin and ofloxacin, recent reports have implicated the newer fluoroquinolone levofloxacin. Recognition of fluoroquinolone-induced cutaneous vasculitis is important as continuation or re-exposure of the offending agent may have life-threatening consequences.