Mindfully and confidently digital: A mixed methods study on personal resources to mitigate the dark side of digital working.

A growing body of research demonstrates the potential of mindfulness to reduce employee stress. However, with work increasingly migrating from the physical to the digital workplace, evidence is lacking on how mindfulness might help employees live healthy digital working lives. In addition, employees' confidence when using the digital workplace is seen as important for productivity but may also play a role in reducing well-being impacts from digital working. Using the Job-Demands Resources model as a theoretical foundation, 142 workers were surveyed regarding their levels of trait mindfulness and digital workplace confidence, along with their experiences of the dark side effects (stress, overload, anxiety, Fear of Missing Out and addiction) and well-being outcomes (burnout and health). 14 workers were also interviewed to provide qualitative insights on these constructs. Results from regression analyses indicated that more digitally confident workers were less likely to experience digital workplace anxiety, while those with higher mindfulness were better protected against all of the dark side of digital working effects. Interview data indicated ways in which digital mindfulness helps protect well-being, as well as how digital workplace confidence enables healthier digital habits.

Comparison of semantic and phonological false memories in short- and long-term tests.

The Deese-Roediger-McDermott (DRM) paradigm has been at the centre of false memory research. Whereas most work with this paradigm has examined memory at the long term and with semantically associated lists, the present study examines phonological and semantic false memories at both short- and long-term delays. In two experiments, participants studied short lists containing six (Experiment 1) or four (Experiment 2) items, either semantically or phonologically related to the same non-studied critical items (CI). Following each list, participants completed 36 trials of an immediate recognition task (short-term memory [STM]-only condition) only or they also completed a surprise recognition test after a 1-min delay after all 36 STM trials (STM + long-term memory [LTM] condition). In STM, false alarms were higher in phonological lists, whereas after the delay, false alarms were higher in semantic lists, reflecting differential sensitivity to the type of association as a function of delay. A third experiment examined LTM performance after controlling for prior testing and yielded highly similar results. Both the activation-monitoring framework (AMF) and fuzzy-trace theory (FTT) can explain the majority of the findings, with some remaining issues. These results confirm that information from the knowledge base (LTM) does influence accuracy in an STM task, albeit less so than perceptual level similarity.

Economic Evaluation of Extended-Release Buprenorphine for Persons With Opioid Use Disorder.

Importance: In 2017, the US Food and Drug Administration (FDA) approved a monthly injectable form of buprenorphine, extended-release buprenorphine; published data show that extended-release buprenorphine is effective compared with no treatment, but its current cost is higher and current retention is lower than that of transmucosal buprenorphine. Preliminary research suggests that extended-release buprenorphine may be an important addition to treatment options, but the cost-effectiveness of extended-release buprenorphine compared with transmucosal buprenorphine remains unclear. Objective: To evaluate the cost-effectiveness of extended-release buprenorphine compared with transmucosal buprenorphine. Design, Setting, and Participants: This economic evaluation used a state transition model starting in 2019 to simulate the lifetime of a closed cohort of individuals with OUD presenting for evaluation for opioid agonist treatment with buprenorphine. The data sources used to estimate model parameters included cohort studies, clinical trials, and administrative data. The model relied on pharmaceutical costs from the Federal Supply Schedule and health care utilization costs from published studies. Data were analyzed from September 2021 to January 2023. Interventions: No treatment, treatment with transmucosal buprenorphine, or treatment with extended-release buprenorphine. Main Outcomes and Measures: Mean lifetime costs per person, discounted quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs). Results: The simulated cohort included 100 000 patients with OUD receiving (61% male; mean [SD] age, 38 [11] years) or not receiving medication treatment (58% male, mean [SD] age, 48 [18] years). Compared with no medication treatment, treatment with transmucosal buprenorphine yielded an ICER of $19 740 per QALY. Compared with treatment with transmucosal buprenorphine, treatment with extended-release buprenorphine yielded lower effectiveness by 0.03 QALYs per person at higher cost, suggesting that treatment with extended-release buprenorphine was dominated and not preferred. In probabilistic sensitivity analyses, treatment with transmucosal buprenorphine was the preferred strategy 60% of the time. Treatment with extended-release buprenorphine was cost-effective compared with treatment with transmucosal buprenorphine at a $100 000 per QALY willingness-to-pay threshold only after substantial changes in key parameters. Conclusions and Relevance: In this economic evaluation of extended-release buprenorphine compared with transmucosal buprenorphine for the treatment of OUD, extended-release buprenorphine was not associated with efficient allocation of limited resources when transmucosal buprenorphine was available. Future initiatives should aim to improve retention rates or decrease costs associated with extended-release buprenorphine.

Racial disparities in functional outcomes following mechanical thrombectomy in a cohort of patients with ischemic stroke.

BACKGROUND: Non-Hispanic Black (NHB) patients experience increased prevalence of stroke risk factors and stroke incidence compared with non-Hispanic White (NHW) patients. However, little is known about >90-day post-stroke functional outcomes following mechanical thrombectomy. OBJECTIVE: To describe patient characteristics, evaluate stroke risk factors, and analyze the adjusted impact of race on long-term functional outcomes to better identify and limit sources of disparity in post-stroke care. METHODS: We retrospectively reviewed 326 patients with ischemic stroke who underwent thrombectomy at two centers between 2019 and 2022. Race was self-reported as NHB, NHW, or non-Hispanic Other. Stroke risk factors, insurance status, procedural parameters, and post-stroke functional outcomes were collected. Good outcomes were defined as modified Rankin Scale score ≤2 and/or discharge disposition to home/self-care. To assess the impact of race on outcomes at 3-, 6-, and 12-months' follow-up, we performed univariate and multivariate logistic regression. RESULTS: Patients self-identified as NHB (42%), NHW (53%), or Other (5%). 177 (54.3%) patients were female; the median (IQR) age was 67.5 (59-77) years. The median (IQR) National Institutes of Health Stroke Scale score was 15 (10-20). On univariate analysis, NHB patients were more likely to have poor short- and long-term functional outcomes, which persisted on multivariate analysis as significant at 3 and 6 months but not at 12 months (3 months: OR=2.115, P=0.04; 6 months: OR=2.423, P=0.048; 12 months: OR=2.187, P=0.15). NHB patients were also more likely to be discharged to rehabilitation or hospice/death than NHW patients after adjusting for confounders (OR=1.940, P=0.04). CONCLUSIONS: NHB patients undergoing thrombectomy for ischemic stroke experience worse 3- and 6-month functional outcomes than NHW patients after adjusting for confounders. Interestingly, this disparity was not detected at 12 months. Future research should focus on identifying social determinants in the short-term post-stroke recovery period to improve parity in stroke care.

Does Human Papillomavirus Play a Causative Role in Prostate Cancer? A Systematic Review Using Bradford Hill's Criteria.

Globally, prostate cancer is the fifth most common cause of cancer-related death among men, and metastatic castration-resistant prostate cancer has a high cancer-related mortality rate. However, the aetiology of this disease is not yet fully understood. While human papillomavirus (HPV) has been associated with several types of cancer, including cervical, anal, and oropharyngeal cancers, studies investigating the relationship between HPV and prostate cancer have shown mixed results. This systematic review aimed to evaluate the causative association between HPV and prostate cancer using Bradford Hill's criteria. A comprehensive search of PubMed was conducted, and 60 out of 482 studies were included in the review. The included studies were evaluated based on nine Bradford Hill criteria, and information on the identification and transmission of the virus and potential oncogenic mechanisms was also extracted. The strength of association criterion was not met, and other criteria, such as consistency and coherence, were not fulfilled. However, biological plausibility was supported, and potential oncogenic mechanisms were identified. While some studies have reported the presence of HPV in prostate cancer tissues, the overall quality of evidence remains low, and the association between HPV and prostate cancer is weak. Nevertheless, the prostate is a potential reservoir for the transmission of HPV, and the HPV E6 and E7 oncoproteins and inflammation are likely to be involved in any oncogenic mechanisms. Further studies with a higher level of evidence are needed to establish a definitive link between HPV and prostate cancer.

Keep It Up! 3.0: Study protocol for a type III hybrid implementation-effectiveness cluster-randomized trial.

BACKGROUND: Despite evidence that eHealth approaches can be effective in reducing HIV risk, their implementation requirements for public health scale up are not well established, and effective strategies to bring these programs into practice are still unknown. Keep It Up! (KIU!) is an online program proven to reduce HIV risk among young men who have sex with men (YMSM) and ideal candidate to develop and evaluate novel strategies for implementing eHealth HIV prevention programs. KIU! 3.0 is a Type III Hybrid Effectiveness-Implementation cluster randomized trial designed to 1) compare two strategies for implementing KIU!: community-based organizations (CBO) versus centralized direct-to-consumer (DTC) recruitment; 2) examine the effect of strategies and determinants on variability in implementation success; and 3) develop materials for sustainment of KIU! after the trial concludes. In this article, we describe the approaches used to achieve these aims. METHODS: Using county-level population estimates of YMSM, 66 counties were selected and randomized 2:1 to the CBO and DTC approaches. The RE-AIM model was used to drive outcome measurements, which were collected from CBO staff, YMSM, and technology providers. Mixed-methods research mapped onto the domains of the Consolidated Framework for Implementation Research will examine determinants and their relationship with implementation outcomes. DISCUSSION: In comparing our implementation recruitment models, we are examining two strategies which have shown effectiveness in delivering health technology interventions in the past, yet little is known about their comparative advantages and disadvantages in implementation. The results of the trial will further the understanding of eHealth prevention intervention implementation.

Heuristic decision-making across adulthood.

In general, research on aging and decision-making has grown in recent years. Yet, little work has investigated how reliance on classic heuristics may differ across adulthood. For example, younger adults rely on the availability of information from memory when judging the relative frequency of plane crashes versus car accidents, but it is unclear if older adults are similarly reliant on this heuristic. In the present study, participants aged 20-90 years old made judgments that could be answered by relying on five different heuristics: anchoring, availability, recognition, representativeness, and sunk-cost bias. We found no evidence of age-related differences in the use of the classic heuristics-younger and older adults employed anchoring, availability, recognition, and representativeness to equal degrees in order to make decisions. However, replicating past work, we found age-related differences in the sunk-cost bias-older adults were more likely to avoid this fallacy compared to younger adults. We explain these different patterns by drawing on the distinctive roles that stored knowledge and personal experience likely play across heuristics. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Usability of existing global and national data for flood related vulnerability assessment in Indonesia.

Public climatic data are rapidly growing in volume and complexity at global and national scales but these data remain underutilized for vulnerability assessment. We aim to explore how flood records from Dartmouth Flood Observatory, a global flood monitoring database, can be linked with a national disaster database maintained by the Indonesian National Board for Disaster Management, to aid local vulnerability assessment in Indonesia. We focused on physical damage to structures and agricultural crops from flooding and examined spatiotemporal patterns of a vulnerability metric derived from principal component analysis. We identified the most vulnerable areas based on emerging hot spot analysis and detected sporadic hotspots (i.e. on again then off again) of flooding in Jakarta and West Java. Using our derived metric, we identified oscillating cold spots (i.e. a cold spot that was previously a hot spot) of vulnerability in Banten, Jakarta, West Java, and Central Java. The detection of nonhomogeneous spatiotemporal trends in flooding and vulnerability demonstrate potential usability of public climate data and help to outline directions for novel research.

Study to investigate the prevalence of human papillomavirus in Barrett's oesophagus using a novel screening methodology.

INTRODUCTION: Human papillomavirus (HPV) is strongly associated with Barrett's dysplasia and oesophageal cancer suggesting a role in carcinogenesis. HPV persistence predicts treatment failure after endotherapy for Barrett's dysplasia. This pilot study applies a novel HPV screening tool (previously only used in the oropharynx) to detect HPV DNA directly and determine the prevalence rates in Barrett's oesophagus (BO). METHOD: DNA was extracted from 20 formalin-fixed BO samples. HPV DNA was detected using real-time PCR and gel electrophoresis. RESULTS: 5 out of 20 patients were identified as positive for HPV. Prevalence was 25% in patients with BO. CONCLUSION: This method can be used in BO's tissue to determine HPV infection. Adoption of this as a screening test could potentially revolutionise future research in this area. If a clear link between HPV and Barrett's dysplasia can be confirmed, this qPCR method has the potential to aid in monitoring and/or dysplasia detection by stratifying those most at risk and aid in the development of new therapies.

Prior exposure increases judged truth even during periods of mind wandering.

Much of our day is spent mind-wandering-periods of inattention characterized by a lack of awareness of external stimuli and information. Whether we are paying attention or not, information surrounds us constantly-some true and some false. The proliferation of false information in news and social media highlights the critical need to understand the psychological mechanisms underlying our beliefs about what is true. People often rely on heuristics to judge the truth of information. For example, repeated information is more likely to be judged as true than new information (i.e., the illusory truth effect). However, despite the prevalence of mind wandering in our daily lives, current research on the contributing factors to the illusory truth effect have largely ignored periods of inattention as experimentally informative. Here, we aim to address this gap in our knowledge, investigating whether mind wandering during initial exposure to information has an effect on later belief in the truth of that information. That is, does the illusory truth effect occur even when people report not paying attention to the information at hand. Across three studies we demonstrate that even during periods of mind wandering, the repetition of information increases truth judgments. Further, our results suggest that the severity of mind wandering moderated truth ratings, such that greater levels of mind wandering decreased truth judgements for previously presented information.

Determining the lower limit of detection required for HCV viral load assay for test of cure following direct-acting antiviral-based treatment regimens: Evidence from a global data set.

Achieving global elimination of hepatitis C virus requires a substantial scale-up of testing. Point-of-care HCV viral load assays are available as an alternative to laboratory-based assays to promote access in hard to reach or marginalized populations. The diagnostic performance and lower limit of detection are important attributes of these new assays for both diagnosis and test of cure. Therefore, our objective was to determine an acceptable LLoD for detectable HCV viraemia as a test for cure, 12 weeks post-treatment (SVR12). We assembled a global data set of patients with detectable viraemia at SVR12 from observational databases from 9 countries (Egypt, the United States, United Kingdom, Georgia, Ukraine, Myanmar, Cambodia, Pakistan, Mozambique) and two pharmaceutical-sponsored clinical trial registries. We examined the distribution of HCV viral load at SVR12 and presented the 90th, 95th, 97th and 99th percentiles. We used logistic regression to assess characteristics associated with low-level virological treatment failure (defined as <1000 IU/mL). There were 5973 cases of detectable viraemia at SVR12 from the combined data set. Median detectable HCV RNA at SVR12 was 287,986 IU/mL. The level of detection for the 95th percentile was 227 IU/mL (95% CI 170-276). Females and those with minimal fibrosis were more likely to experience low-level viraemia at SVR12 compared to men (adjusted odds ratio AOR = 1.60 95% confidence interval [CI] 1.30-1.97 and those with cirrhosis (AOR = 1.49 95% CI 1.15-1.93). In conclusion, an assay with a level of detection of 1000 IU/mL or greater may miss a proportion of those with low-level treatment failure.

A comparison of memories of fiction and autobiographical memories.

People consume, remember, and discuss not only memories of lived experiences, but also events from works of fiction, such as books, movies, and TV shows. We argue that these memories of fiction represent an important category of event memory, best understood within an autobiographical memory framework. How do fictional events yield psychological realities even when they are known to be invented? We explored this question in three studies by comparing the memory content, phenomenological qualities, and functional roles of naturally occurring personal memories to memories of fiction. In Studies 1 and 2, we characterized the subjective experience of memories of fiction by adapting established measures of autobiographical remembering, such as the Autobiographical Memory Questionnaire (Rubin et al., 2003), Centrality of Event Scale (Berntsen & Rubin, 2006), and items from the Thinking About Life Experiences Scale (Bluck et al., 2005; Pillemer et al., 2015). In Study 3, we investigated similarities and differences in personal memories and memories of fiction for events from childhood or the recent past. In doing so, we observed the impact of a unique property of memories of fiction: their ability to be repeatedly reexperienced in their original form. Taken together, we argue that memories of fiction can be considered similar to other forms of autobiographical remembering and describe a theoretical framework for understanding memories of fiction in the context of other event memories. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Predicting others' knowledge in younger and older adulthood.

Our beliefs about aging affect how we interact with others. For example, people know that episodic memory declines with age, and as a result, older adults' memories are less likely to be trusted. However, not all aspects of remembering decline with age; semantic memory (knowledge) increases across adulthood and is relatively unaffected in healthy aging. In the current work, we examined people's awareness of this pattern. Participants estimated the knowledge of hypothetical younger and older adults; in some studies, they also predicted and demonstrated their own knowledge on the same measures. Across studies, both younger and older adults estimated that older adults would perform better on a knowledge test, demonstrating awareness that knowledge is not impaired with aging. Furthermore, people's beliefs about their own knowledge influenced the predictions they made about others' knowledge. We discuss how this work informs theories of metacognition and contributes to positive self-perceptions in older adulthood.

Transfer of category learning to impoverished contexts.

Learning often happens in ideal conditions, but then must be applied in less-than-ideal conditions - such as when a learner studies clearly illustrated examples of rocks in a book but then must identify them in a muddy field. Here we examine whether the benefits of interleaving (vs. blocking) study schedules, as well as the use of feature descriptions, supports the transfer of category learning in new, impoverished contexts. Specifically, keeping the study conditions constant, we evaluated learners' ability to classify new exemplars in the same neutral context versus in impoverished contexts in which certain stimulus features are occluded. Over two experiments, we demonstrate that performance in new, impoverished contexts during test is greater for participants who received an interleaved (vs. blocked) study schedule, both for novel and for studied exemplars. Additionally, we show that this benefit extends to both a short (3-min) or long (48-h) test delay. The presence of feature descriptions during learning had no impact on transfer. Together, these results extend the growing literature investigating how changes in context during category learning or test impacts performance and provide support for the use of interleaving to promote the far transfer of category knowledge to impoverished contexts.

Individual Differences in Structure Building: Impacts on Comprehension and Learning, Theoretical Underpinnings, and Support for Less Able Structure Builders.

In this article, we highlight an underappreciated individual difference: structure building. Structure building is integral to many everyday activities and involves creating coherent mental representations of conversations, texts, pictorial stories, and other events. People vary in this ability in a way not generally captured by other better known concepts and individual difference measures. Individuals with lower structure-building ability consistently perform worse on a range of comprehension and learning measures than do individuals with higher structure-building ability, both in the laboratory and in the classroom. Problems include a range of comprehension processes, including encoding factual content, inhibiting irrelevant information, and constructing a cohesive situation model of a text or conversation. Despite these problems, recent research is encouraging in that techniques to improve the learning outcomes for low-ability structure builders have been identified. We argue that the accumulated research warrants the recognition of structure building as an important individual difference in cognitive functioning and that additional theoretical work is needed to understand the underpinnings of structure-building deficits.

Externalizing autobiographical memories in the digital age.

People externalize their autobiographical memories by creating representations that exist outside of their minds. Externalizations often serve personal and social functions, consistent with theorized functions of autobiographical memory. With new digital technologies, people are documenting more memories than ever and are sharing them with larger audiences. However, these technologies do not change the core cognitive processes involved in autobiographical memory, but instead present novel situations that affect how these processes are deployed. Smartphones allow events to be recorded as they unfold, thus directing attention and sometimes impairing memory. Social media increase the frequency of reviewing and sharing records which reactivate memories, potentially strengthening or updating them. Overall, externalization in the digital age changes what people attend to and remember about their own experiences.

Manipulations of List Type in the DRM Paradigm: A Review of How Structural and Conceptual Similarity Affect False Memory.

The use of list-learning paradigms to explore false memory has revealed several critical findings about the contributions of similarity and relatedness in memory phenomena more broadly. Characterizing the nature of "similarity and relatedness" can inform researchers about factors contributing to memory distortions and about the underlying associative and semantic networks that support veridical memory. Similarity can be defined in terms of semantic properties (e.g., shared conceptual and taxonomic features), lexical/associative properties (e.g., shared connections in associative networks), or structural properties (e.g., shared orthographic or phonological features). By manipulating the type of list and its relationship to a non-studied critical item, we review the effects of these types of similarity on veridical and false memory. All forms of similarity reviewed here result in reliable error rates and the effects on veridical memory are variable. The results across a variety of paradigms and tests provide partial support for a number of theoretical explanations of false memory phenomena, but none of the theories readily account for all results.

Exploring the Collateral Damage of the COVID-19 Pandemic on Stroke Care: A Statewide Analysis.

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Cheaters claim they knew the answers all along.

Cheating has become commonplace in academia and beyond. Yet, almost everyone views themselves favorably, believing that they are honest, trustworthy, and of high integrity. We investigate one possible explanation for this apparent discrepancy between people's actions and their favorable self-concepts: People who cheat on tests believe that they knew the answers all along. We found consistent correlational evidence across three studies that, for those particular cases in which participants likely cheated, they were more likely to report that they knew the answers all along. Experimentally, we then found that participants were more likely to later claim that they knew the answers all along after having the opportunity to cheat to find the correct answers - relative to exposure to the correct answers without the opportunity to cheat. These findings provide new insights into relationships between memory, metacognition, and the self-concept.

Internal states and interoception along a spectrum of eating disorder symptomology.

OBJECTIVE: Recent studies on atypical interoceptive capabilities have focused on clinical populations, including anorexia nervosa[1,2]. The present exploratory study aims to characterize the influence of disordered eating symptomology on interoceptive capabilities in college students, a population for which dangerous dieting behaviors may emerge. METHOD: Ninety-nine participants were randomized to consume a blinded high calorie or low calorie midday shake. Participants reported frequency of eating disorder cognitions and behaviors; indicated changes in satiety, happiness, and energy pre- and post-consumption; and guessed the calories in their shake. Outcomes (perceived satiety, changes in mood, and caloric guess) were regressed on eating disorder symptoms scores, the high/low calorie shake condition, and the interaction between these predictors. RESULTS: Those randomized to receive the high calorie shake reported feeling fuller, but only when endorsing lower levels of eating concern. Those randomized to the high calorie shake reported greater post-meal happiness, but only at greater levels of eating concerns. Lastly, those with lower levels of eating restraint reported an expected positive association between level of fullness and calorie guess, but those with higher levels of eating restraint did not exhibit any relationship between perceived fullness and calorie guess. DISCUSSION: Results of this exploratory suggest that irregular eating habits (e.g., not eating a sufficient amount for lunch) may have direct consequences on interoceptive capabilities. Further, these capacities may be impacted by individual differences in eating concern and restraint. Preliminary findings suggest that impairment in deciphering visceral signals may be associated with the degree of eating disorder symptomology; such impairment may occur at lower levels of symptomatology than normative data would indicate.