Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Hematuria , Vacunación Masiva/efectos adversos , Vacunas/efectos adversos , Infecciones por Coronavirus/tratamiento farmacológico , Pandemias , Infecciones por Coronavirus/epidemiología , Coronavirus Relacionado al Síndrome Respiratorio Agudo Severo , Glomerulonefritis por IGAAsunto(s)
Humanos , Masculino , Anciano , Trombosis , Síndrome Nefrótico/complicaciones , Antitrombinas , Trombofilia , HipertensiónRESUMEN
Background: The acute and long-term effects of severe acute respiratory syndrome coronavirus 2 infection in individuals with GN are still unclear. To address this relevant issue, we created the International Registry of COVID-19 infection in GN. Methods: We collected serial information on kidney-related and -unrelated outcomes from 125 GN patients (63 hospitalized and 62 outpatients) and 83 non-GN hospitalized patients with coronavirus disease 2019 (COVID-19) and a median follow-up period of 6.4 (interquartile range 2.3-9.6) months after diagnosis. We used logistic regression for the analyses of clinical outcomes and linear mixed models for the longitudinal analyses of eGFR. All multiple regression models were adjusted for age, sex, ethnicity, and renin-angiotensin-aldosterone system inhibitor use. Results: After adjustment for pre-COVID-19 eGFR and other confounders, mortality and AKI did not differ between GN patients and controls (adjusted odds ratio for AKI=1.28; 95% confidence interval [CI], 0.46 to 3.60; P=0.64). The main predictor of AKI was pre-COVID-19 eGFR (adjusted odds ratio per 1 SD unit decrease in eGFR=3.04; 95% CI, 1.76 to 5.28; P<0.001). GN patients developing AKI were less likely to recover pre-COVID-19 eGFR compared with controls (adjusted 6-month post-COVID-19 eGFR=0.41; 95% CI, 0.25 to 0.56; times pre-COVID-19 eGFR). Shorter duration of GN diagnosis, higher pre-COVID-19 proteinuria, and diagnosis of focal segmental glomerulosclerosis or minimal change disease were associated with a lower post-COVID-19 eGFR. Conclusions: Pre-COVID-19 eGFR is the main risk factor for AKI regardless of GN diagnosis. However, GN patients are at higher risk of impaired eGFR recovery after COVID-19-associated AKI. These patients (especially those with high baseline proteinuria or a diagnosis of focal segmental glomerulosclerosis or minimal change disease) should be closely monitored not only during the acute phases of COVID-19 but also after its resolution.
Asunto(s)
Lesión Renal Aguda , COVID-19 , Lesión Renal Aguda/complicaciones , COVID-19/epidemiología , Estudios de Seguimiento , Humanos , Sistema de Registros , SARS-CoV-2RESUMEN
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Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Insuficiencia Renal Crónica/cirugía , Insuficiencia Renal Crónica/terapia , Trasplante de Riñón/efectos adversos , Diálisis Renal , Activación Viral , Hepatitis B , Virus de la Hepatitis B/fisiologíaAsunto(s)
Virus de la Hepatitis B/fisiología , Hepatitis B/diagnóstico , Hepatitis B/prevención & control , Trasplante de Riñón , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/prevención & control , Activación Viral , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/virología , Diálisis RenalRESUMEN
No disponible