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1.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 42(5): 296-301, sept.- oct. 2023. ilus, tab
Artículo en Español | IBECS | ID: ibc-225087

RESUMEN

Introducción La cirugía radioguiada emplea fuentes radioactivas para identificar y extirpar lesiones de difícil localización. Los tumores mesenquimales constituyen un grupo heterogéneo de neoplasias derivados del mesodermo, incluyendo lesiones benignas y sarcomas malignos. El objetivo de este estudio fue evaluar la capacidad de la semilla radioactiva de 125I para guiar la localización intraoperatoria de tumores mesenquimales, analizando sus tasas de complicación y evaluando los márgenes de las piezas quirúrgicas recuperadas. Métodos Estudio observacional retrospectivo de todos los pacientes consecutivos sometidos a cirugía radioguiada de un tumor mesenquimal con semilla radioactiva de 125I desde enero de 2012 hasta enero de 2020 en un centro de referencia terciario en España. La semilla fue insertada mediante punción percutánea guiada con ecografía o tomografía computarizada de forma ambulatoria. Resultados Se extirparon 15 lesiones en 11 cirugías a 11 pacientes, recuperando todas las lesiones marcadas (100%) con semilla de 125I. Las lesiones incluyeron áreas de fibrosis benigna (26,7%), angiofibroma celular (6,7%), tumor desmoide (20%), tumor fibroso solitario (13,3%), condrosarcoma (6,7%) y sarcoma pleomórfico (26,7%), con una tasa elevada de tumores recurrentes (60%). Solo hubo una complicación (6,7%) por caída de la semilla dentro del lecho quirúrgico. Según la clasificación de la Union for International Cancer Control de tumor residual, el 80% de las lesiones resultaron en una resección R0, el 6,7% fueron una resección R1 y el 13,3% fueron una resección R2. Conclusión La cirugía radioguiada fue una técnica precisa para la extirpación de tumores mesenquimales de difícil localización (AU)


Introduction Radioguided surgery uses radioactive substances to identify and remove hard-to-locate lesions. Mesenchymal tumors constitute a heterogeneous group of neoplasms derived from the mesoderm, including benign lesions and malignant sarcomas. The aim of this study was to evaluate the ability of the 125I radioactive seed to guide intraoperative localization of mesenchymal tumors, analyzing its complication rates and evaluating the margins of the surgical specimens retrieved. Methods Retrospective observational study of all consecutive patients undergoing radioguided surgery of a mesenchymal tumor with a 125I radioactive seed from January 2012 to January 2020 at a tertiary referral center in Spain. The seed was inserted percutaneously guided by ultrasound or computed tomography on an outpatient setting. Results Fifteen lesions were removed in 11 surgeries on 11 patients, recovering all marked lesions (100%) with a 125I seed. The lesions included areas of benign fibrosis (26.7%), cellular angiofibroma (6.7%), desmoid tumor (20%), solitary fibrous tumor (13.3%), chondrosarcoma (6.7%), and pleomorphic sarcoma (26.7%), with a high rate of recurrent tumors (60%). There was only one complication (6.7%) due to the seed falling within the surgical bed. According to the UICC classification of residual tumor, 80% of the lesions resulted in an R0 resection, 6.7% were an R1 resection, and 13.3% were an R2 resection. Conclusion Radioguided surgery was a precise technique for the removal of hard-to-locate mesenchymal tumors (AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Cirugía Asistida por Computador , Radiocirugia/métodos , Mesenquimoma/cirugía , Resultado del Tratamiento , Estudios Retrospectivos
2.
J Endocrinol Invest ; 44(12): 2545-2555, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34304388

RESUMEN

OBJECTIVE: To offer a practical guide for the presurgical and anesthetic management of pheochromocytomas and sympathetic paragangliomas (PGLs). METHODS: This protocol was based on a comprehensive review of the literature and on our own multidisciplinary team's experience from managing pheochromocytoma and sympathetic PGLs at a referral center. RESULTS: Patients with pheochromocytomas and sympathetic paragangliomas (PGLs) may develop potentially life-threatening complications, especially during surgical procedures. A complete biochemical, radiological, genetic, and cardiological assessment is recommended in the preoperative stage as it provides an evaluation of the risk of surgical complications and malignancy, allowing individualization of the presurgical treatment. Treatment with α-blockade and proper volume expansion in the preoperative stage significantly reduces the perioperative morbidity. During surgery, the anesthesiologist should look for a deep anesthetic level that inhibits the cardiovascular effects of catecholamines to minimize the risk of intraoperative complications. CONCLUSIONS: An optimal presurgical evaluation of pheochromocytomas/ sympathetic PGL requires a multidisciplinary approach, including a complete hormonal, radiological, cardiac, genetic, and functioning evaluation in most cases. A proper preoperative evaluation in combination with strict blood pressure and heart rate control, and blood volume status optimization, will significantly reduce the risk of intraoperative and perioperative complications. In those patients who unfortunately develop intraoperative complications, the role of the anesthesiologist is essential since the selection of the appropriate management has a direct impact on morbimortality reduction.


Asunto(s)
Neoplasias de las Glándulas Suprarrenales/cirugía , Complicaciones Intraoperatorias/prevención & control , Paraganglioma/cirugía , Feocromocitoma/cirugía , Cuidados Preoperatorios/métodos , Neoplasias de las Glándulas Suprarrenales/patología , Humanos , Paraganglioma/patología , Planificación de Atención al Paciente/normas , Feocromocitoma/patología , Guías de Práctica Clínica como Asunto , Ajuste de Riesgo
3.
Rev. esp. med. nucl. imagen mol. (Ed. impr.) ; 37(5): 273-276, sept.-oct. 2018. tab
Artículo en Español | IBECS | ID: ibc-178218

RESUMEN

Introducción: El bloqueo completo de rama izquierda inducido por el ejercicio (BCRI-IE) es un fenómeno poco frecuente y de significado incierto. El propósito del presente trabajo ha sido describir las características gammagráficas y el valor pronóstico de dicho hallazgo. Material y método: Se han revisado las características de 1.885 pacientes que habían acudido a nuestro servicio a realizarse una ergometría-GATED SPECT para diagnóstico de cardiopatía isquémica. Siete de ellos presentaron BCRI-IE en la prueba de esfuerzo. Se realizó coronariografía a 4 de los 7 pacientes. Estos pacientes se han seguido durante un tiempo medio de 30±8 meses. Se investigó la aparición de eventos cardiovasculares mayores. Resultados: La prevalencia del BCRI-IE fue del 0,37%. Seis de los 7 pacientes eran mujeres. La perfusión y la función miocárdicas fueron normales en 3 pacientes. Tres pacientes presentaron defectos fijos de la perfusión y uno un defecto reversible. Dos de estos pacientes presentaron una FEVI moderada-severamente deprimida. Las coronarias fueron normales en los 4 pacientes con defectos de la perfusión. Conclusiones: La prevalencia del BCRI-IE entre los pacientes que acudieron a realizarse una ergometría con estudio de perfusión miocárdica fue muy baja. El hallazgo fue mucho más frecuente en mujeres. En nuestra serie 2 pacientes presentaron cardiopatía estructural de origen no isquémico pero ninguno fue diagnosticado de enfermedad coronaria. En nuestra serie la presencia de BCRI-IE no se asoció a un mayor riesgo de eventos cardiovasculares mayores


Introduction: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. Material and methods: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them. Patients were followed-up over an average period of time of 30±8 months. The onset of major cardiovascular events was recorded during the follow-up period. Results: The prevalence of EI-LBBB was 0.37%. Six out of 7 patients were women. Myocardial function and perfusion were normal in 3 patients. Three patients had fixed perfusion defects and one patient had a reversible defect. Two out of the 4 patients showing perfusion defects presented a moderate-severe decrease of the left ventricular ejection fraction. None of the 4 patients with perfusion defects were found to have coronary disease on coronary angiography. Conclusions: The prevalence of EI-LBBB among the patients that came to undergo GATED-SPECT ergometry was very low. The finding was more frequent in women. In our series, 2 patients presented non-ischaemic structural heart disease, but no patient was diagnosed with coronary artery disease. In our patients the presence of EI-LBBB did not relate to a greater risk of experiencing a major cardiovascular event


Asunto(s)
Humanos , Bloqueo de Rama/etiología , Ergometría/efectos adversos , Prueba de Esfuerzo/efectos adversos , Tomografía Computarizada por Emisión de Fotón Único Sincronizada Cardíaca/métodos , Factores de Riesgo , Isquemia Miocárdica/diagnóstico por imagen , Estudios Retrospectivos , Cintigrafía/métodos
4.
Artículo en Inglés, Español | MEDLINE | ID: mdl-29680771

RESUMEN

INTRODUCTION: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. MATERIAL AND METHODS: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them. Patients were followed-up over an average period of time of 30±8 months. The onset of major cardiovascular events was recorded during the follow-up period. RESULTS: The prevalence of EI-LBBB was 0.37%. Six out of 7 patients were women. Myocardial function and perfusion were normal in 3 patients. Three patients had fixed perfusion defects and one patient had a reversible defect. Two out of the 4 patients showing perfusion defects presented a moderate-severe decrease of the left ventricular ejection fraction. None of the 4 patients with perfusion defects were found to have coronary disease on coronary angiography. CONCLUSIONS: The prevalence of EI-LBBB among the patients that came to undergo GATED-SPECT ergometry was very low. The finding was more frequent in women. In our series, 2 patients presented non-ischaemic structural heart disease, but no patient was diagnosed with coronary artery disease. In our patients the presence of EI-LBBB did not relate to a greater risk of experiencing a major cardiovascular event.


Asunto(s)
Bloqueo de Rama/etiología , Prueba de Esfuerzo/efectos adversos , Anciano , Bloqueo de Rama/diagnóstico por imagen , Bloqueo de Rama/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Imagen de Perfusión Miocárdica , Prevalencia , Pronóstico
11.
Rev Esp Med Nucl Imagen Mol ; 34(1): 77-8, 2015.
Artículo en Español | MEDLINE | ID: mdl-25112887
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