RESUMEN
A study was made on 8 eyes of 5 patients between 47 and 65 years of age with peripapillary pachychoroidopathy. They all presented with a serous detachment of the neuroepithelium or retinal pigment epithelium in the nasal macular region that extended to the optic disc, with an increase in choroidal thickness at that level. An analysis was made of the choroidal thickness using high penetration optical coherence tomography, as well as their outcome in a period between 12 and 48 months. Peripapillary pachychoroidopathy is a distinct variant of the pachychoroid disease spectrum. It must be distinguished from other disorders, such as inflammatory or neuro-ophthalmological conditions, that may manifest in the vicinity of the optic disc. When faced with a patient with suspected pachychoroidopathy, a specific study of the papillary area should be considered using high penetration optical coherence tomography.
RESUMEN
A 32 year-old man who presented with severe elevation of blood pressure after failure of kidney transplant. The patient had multiple serous retinal detachments, venous dilation, arteriolar narrowing, retinal haemorrhages, as well as optic disc oedema. Due to the impossibility of performing a fluorescein angiography, an angiotomography and en-face optical coherence tomography images were used to identify the vascular alterations in the retina, choroid, and choriocapillaris. Angiotomography and en face-optical coherence tomography mode images are very useful in cases where it is not possible to perform fluorescein angiography.
Asunto(s)
Hipertensión Maligna/complicaciones , Trasplante de Riñón/efectos adversos , Adulto , Inhibidores de la Angiogénesis/uso terapéutico , Bevacizumab/uso terapéutico , Coroides/irrigación sanguínea , Coroides/diagnóstico por imagen , Humanos , Riñón/lesiones , Edema Macular/tratamiento farmacológico , Edema Macular/etiología , Masculino , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Insuficiencia Renal/cirugía , Desprendimiento de Retina/diagnóstico por imagen , Desprendimiento de Retina/etiología , Hemorragia Retiniana/diagnóstico por imagen , Hemorragia Retiniana/etiología , Oclusión de la Vena Retiniana/diagnóstico por imagen , Oclusión de la Vena Retiniana/etiología , Tomografía de Coherencia Óptica , Insuficiencia del TratamientoAsunto(s)
Fondo de Ojo , Disco Óptico/irrigación sanguínea , Macroaneurisma Arterial de Retina/diagnóstico por imagen , Retinitis/diagnóstico por imagen , Enfermedad Aguda , Anciano , Femenino , Angiografía con Fluoresceína , Humanos , Disco Óptico/diagnóstico por imagen , Tomografía de Coherencia ÓpticaRESUMEN
CASE REPORT: The case is presented of a 39-year-old woman with metastatic melanoma treated with dabrafenib and trametinib. She presented with a severe acute panuveitis with granulomatous anterior uveitis, vitritis, and multiple serous retinal detachments. Dabrafenib and trametinib were suspended, and treatment with a systemic and topical corticosteroid was started. A good response was obtained, with a recovery of visual acuity of 1.0 in both eyes within two weeks. DISCUSSION: Dabrafenib and trametinib can lead to severe uveitis. Treatment with corticosteroids and discontinuation of therapy with dabrafenib and trametinib led to an anatomical and functional improvement, and resolved the episode rapidly. Ophthalmologists must be aware of this toxicity, given the increasing use of those drugs.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Imidazoles/efectos adversos , Oximas/efectos adversos , Panuveítis/inducido químicamente , Piridonas/efectos adversos , Pirimidinonas/efectos adversos , Desprendimiento de Retina/inducido químicamente , Corticoesteroides/uso terapéutico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Azetidinas/administración & dosificación , Azetidinas/efectos adversos , Sinergismo Farmacológico , Resultado Fatal , Femenino , Humanos , Imidazoles/administración & dosificación , Quinasas Quinasa Quinasa PAM/antagonistas & inhibidores , Melanoma/tratamiento farmacológico , Melanoma/secundario , Proteínas de Neoplasias/antagonistas & inhibidores , Oximas/administración & dosificación , Panuveítis/tratamiento farmacológico , Piperidinas/administración & dosificación , Piperidinas/efectos adversos , Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores , Piridonas/administración & dosificación , Pirimidinonas/administración & dosificación , Vemurafenib/administración & dosificaciónRESUMEN
CASE REPORT: The case is presented of a 45 year-old man with a focal choroidal excavation associated with choroidal neovascularisation not included in the area of excavation. Clinical features were analysed using retinography, fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. The patient was treated with 3 intravitreal injections of bevacizumab, with a good response. DISCUSSION: Focal choroidal excavation can be associated with choroidal neovascularization not included in the area of excavation. Multimodal imaging provides a complete description of clinical features, before and after treatment.
Asunto(s)
Enfermedades de la Coroides/complicaciones , Neovascularización Coroidal/complicaciones , Enfermedades de la Coroides/diagnóstico por imagen , Neovascularización Coroidal/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana EdadRESUMEN
CASE REPORT: The case is presented of a 42 year-old man with episodes of unilateral uveitis in his right eye. Ophthalmic examination showed a granulomatous anterior uveitis with vitritis. Systemic investigations revealed non-nephrotic proteinuria and microhaematuria. A renal biopsy showed IgA nephropathy. DISCUSSION: Uveitis and glomerulonephritis may have common immunological pathogenesis. IgA nephropathy should be a differential diagnosis in patients with uveitis and nephropathy.