RESUMEN
Objetivo: identificar o impacto científico da Estratégia PICO (Population, Intervention, Comparison, Outcomes) na qualidade de vida de pacientes hemodialíticos. Método: trata-se de uma revisão integrativa realizada no PubMed, MeSH e Cochrane Library cuja amostra foi composta por 13 artigos. A coleta dos dados foi realizada durante o período de maio a agosto de 2021. Resultados: verificou-se que a qualidade de vida do paciente hemodialítico é prejudicada em diversos segmentos, sendo os principais: redução da capacidade funcional; incapacidade de ser independente, de forma pessoal e profissional; e o impacto na saúde mental, em decorrencia das alterações cotidianas que o tratamento exige em seu dia-a-dia. Conclusão: Em todos os estudos, a qualidade de vida e psíquica do paciente hemodialítico encontra-se prejudicada e associada a fatores negativos.(AU)
Objective: To identify the scientific impact of the PICO (Population, Intervention, Comparison, Outcomes) strategy on the quality of life of hemodialysis patients. Method: this is an integrative review conducted in PubMed, MeSH and Cochrane Library whose sample was composed of 13 articles. Data collection was carried out from May to August 2021. Results: It was found that the quality of life of hemodialysis patients is impaired in several segments, the main ones being: reduced functional capacity; inability to be independent, personally and professionally; and the impact on mental health, due to the daily changes that treatment requires in their daily lives. Conclusion: In all studies, the quality of life and mental health of hemodialysis patients is impaired and associated with negative factors.(AU)
Objetivo: Identificar el impacto científico de la estrategia PICO (Population, Intervention, Comparison, Outcomes) sobre la calidad de vida de los pacientes en hemodiálisis. Método: se trata de una revisión integradora realizada en PubMed, MeSH y Cochrane Library cuya muestra consistió en 13 artículos. La recopilación de datos se realizó durante el período de mayo a agosto de 2021. Resultados: se verificó que la calidad de vida del paciente hemodialitico se ve perjudicada en varios segmentos, siendo los principales: la reducción de la capacidad funcional; la incapacidad de ser independiente, de forma personal y profesional; y el impacto en la salud mental, en decadencia de las alteraciones cotidianas que el tratamiento exige en su día a día. Conclusión: En todos los estudios, la calidad de vida y psíquica del paciente hemodialitico se encuentra perjudicada y asociada a factores negativos.(AU)
Asunto(s)
Calidad de Vida , Diálisis Renal , Insuficiencia Renal CrónicaRESUMEN
PURPOSE: Whey protein has antioxidant properties through its amino acid cysteine, which enhances the biosynthesis of glutathione, the most abundant antioxidant non-protein in mammalians. Glutathione influences vitamin C recycling and increases its protective effect on oxidative stress (OS). The aim of this study was to analyse the effect of whey protein and vitamin C supplementation on OS biomarkers in chronic haemodialysis (HD) patients. METHODS: This pioneer trial was a randomised, double-blind, pilot study in patients from a dialysis clinic. Patients were randomised into three groups (1:1:1) and stratified by HD frequency (2 or 3 times/week). Sachets containing protein powder (20.0 g) with/without vitamin C (0.25 g) or placebo (20.0 g of white rice flour) with vitamin C (0.25 g) were supplemented after each HD session, 3 times/week for 8 weeks. Blood samples were collected at the baseline period and after 8 weeks for the measurement of reduced glutathione (GSH), oxidised glutathione (GSSG), the GSH:GSSG ratio, malondialdehyde, vitamin C, and glutathione peroxidase-1. RESULTS: Twenty-two patients were enrolled, of which 18 concluded the trial, 6 per group (18.2%, n = 4 losses during follow-up). The vitamin C group presented decreased GSH levels after supplementation (p = 0.053) and a decreasing tendency in the GSH:GSSG ratio (non-statistically significant), while MDA levels significantly decreased only in the whey protein-supplemented groups (p ≤ 0.05). CONCLUSION: The results suggest a pro-oxidant effect of 0.25 g of vitamin C alone in chronic HD patients. CLINICAL TRIAL REGISTRATION: https://ensaiosclinicos.gov.br/ , RBR-65b8f4.
