Effects of Multimodal Analgesia on Recovery From Percutaneous Spinal Cord Stimulator Implantation.

OBJECTIVE: We aimed to determine the relationship between number and type of analgesic modalities utilized and postoperative pain after percutaneous spinal cord stimulator implantation. Secondary measures include opioid requirements, discharge times, and effects of specific modalities. MATERIALS AND METHODS: This single-center retrospective cohort at Brooke Army Medical Center from April 2008 through July 2017 reviewed 70 patients undergoing stimulator implantation by a pain specialist. Data included: home opioid regimen; preoperative/postoperative medications and pain; intraoperative medications; and discharge times. Analysis utilized a Wilcoxon nonparametric mode, and chi-square testing for specific modalities. We compared outcomes based on the number of modalities administered and whether patients received specific medications. RESULTS: Patients averaged receiving 3.8 modalities (standard deviation 1.4). Patients receiving ≥5 modalities had increased pain from preoperative to postoperative scores by two points, while those who received ≤4 had no increase (p < 0.01). Patients receiving ketamine had a median three point increase in pain scores from their baseline vs no change for others (p < 0.05). Patients receiving four modalities had shorter phase one recovery times vs ≤ 2 (median 66 vs 91.5 min; p = 0.01). Patients receiving ≥4 modalities had shorter times vs ≤3 (median 74 vs 88.5 min; p < 0.01). Patients receiving NSAIDs had shorter times than others (median 78 vs 87 min; p < 0.05). CONCLUSIONS: Ketamine administration and use of ≥5 analgesic modalities were associated with more postoperative pain for unclear reasons. Patients receiving NSAIDs or ≥4 analgesic modalities had shorter recovery times. These data may lead to further work that could optimize ambulatory practices for stimulator implantation. More work is warranted on this subject.

Hybrid oxygen-responsive reflective Bragg grating platforms.

Oxygen responsive sensor platforms were fabricated by pin printing tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) ([Ru(dpp)(3)](2+)) doped sols onto wavelength tuned reflective Bragg gratings. In an epi-luminescence configuration, these Bragg gratings (Gr) were designed to selectively reflect the O(2) responsive [Ru(dpp)(3)](2+) emission toward the detector to enhance the detected signal magnitude. The xerogel based sensors were formed onto (i) glass (XGl), (ii) directly on top of the grating (XGrGl), or (iii) on the glass substrate opposite the grating (XGlGr). The results show that all sensors exhibit linear, statistically equivalent O(2) sensitivities, and the XGrGl platform yields up to an 8-fold increase in relative detected analytical signal (RDAS) in comparison to the control (XGl) platform.