Neurotrophins and Migraine.

Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to neuropeptides release such as calcitonin gene-related peptide (CGRP) and substance P (SP). This triggers an inflammatory cascade causing a neurogenic inflammation. The agents responsible for trigeminal activation and release of neuropeptides are still unclear. It is known that the transient receptor potential vanilloid receptor-1 (TRPV1) is an important mediator of CGRP and SP release. TRPV1 is closely associated with tyrosine receptors kinases (Trk), which are NTs receptors. NTs can act on TRPV1 increasing its sensitivity to painful stimuli, therefore predisposing to hyperalgesia. Upregulation of ion channels and pain receptors in dorsal root ganglion neurons may be alternative mechanisms by which NTs contribute to pain development. Only a few studies have been performed to investigate the role of NTs in migraine. These studies have reported changes in NTs levels in migraine patients either during the migraine attack or in free-headache periods.

Poor quality diet is associated with overweight status and obesity in patients with polycystic ovary syndrome.

BACKGROUND: The high rates of overweight status observed in women with polycystic ovary syndrome (PCOS) may reflect dietary intake, and so it is important to investigate diet quality and its relationship with the rates of overweight status and obesity among these patients. METHODS: A cross-sectional study was conducted in which 100 women with PCOS (Rotterdam criteria) were evaluated considering anthropometric and dietary data. The anthropometric evaluation included the measurement of weight, height, body mass index (BMI), waist circumference (WC), hip circumference and waist-hip ratio. Food intake data were collected from two 24-h dietary recalls to assess dietary patterns using the Brazilian Healthy Eating Index - Revised (BHEI-R). RESULTS: The anthropometric analysis indicated a high prevalence of overweight status, obesity and increased visceral fat (30.0%, 60.0% and 90.0%, respectively). The mean BHEI-R score was 56.1 ± 12.0 points (range 34.5-77.5 points). Diet quality was negatively correlated with obesity, which was evaluated by BMI (r = -0.248; P = 0.013) and WC (r = -0.278; P = 0.005). CONCLUSIONS: Dietary interventions focused on improvement of diet quality should be targeted to treat patients with PCOS because obesity in these women is associated with worsening endocrine, metabolic and reproductive functions.

Including the people with disabilities at work: a case study of the job of bricklayer in civil construction in Brazil.

The aim of this paper is to present the results of the evaluation of the job of bricklayer in the construction industry to determine the profile of workers with disabilities who could perform this function and what adjustments are needed. The methods and techniques used in the field study were: direct observation of the activities and the environment, interviews with bricklayers on building sites, a video and photographic record of tasks being carried out to analyze the job of bricklayer, software resources were used. This study set out the disabilities most commonly caused by work accidents in the civil construction industry and simulated the conditions of the individuals to determine whether they could perform the activities of this function and what adaptations are needed. It was observed that workers with hearing impairments could perform activities without any change in the workplace and individuals who had had a leg or foot amputated need to use appropriate prostheses to perform the activities of the function. Thus, it was shown that the activity of professionals with experience in Ergonomics is essential since, by the activity of gathering data and analysing the physical, cognitive and organizational requirements of jobs and by collecting data on and analysing the functional capabilities of the worker with a disability, adaptations to jobs can be adequately defined.

Issues concerning scientific production of including people with disabilities at work.

This article presents the results of a survey carried out on leading periodicals in the areas of Ergonomics, Physiotherapy and Occupational Therapy, the aim of which was to identify scientific publications on the inclusion at work of people with disabilities. The survey of articles published on this topic in the following journals was conducted in December 2010: Applied Ergonomics, Ergonomics, the International Journal of Industrial Ergonomics, Disability and Rehabilitation, and the Journal of Occupational Rehabilitation. The survey covered issues published between 2000 and 2010 and was conducted electronically using the CAPES Periodicals Portal. To collect the articles, it was necessary to check the articles published in each of the issues of each volume of these periodicals. This is how the articles on the topic in question were found. There were 27 articles on the topic of inclusion at work of people with disabilities, of which 13 were published in the Journal of Occupational Rehabilitation and 12 in Disability and Rehabilitation. Thus, it is clear that the issue in question is still a subject that is seldom dealt with in these publications and it is noted that only two articles were published in Ergonomics journals in this period, thus confirming the paucity of scientific publications on this subject.

Ergonomics, design universal and fashion.

People who lie beyond the "standard" model of users often come up against barriers when using fashion products, especially clothing, the design of which ought to give special attention to comfort, security and well-being. The principles of universal design seek to extend the design process for products manufactured in bulk so as to include people who, because of their personal characteristics or physical conditions, are at an extreme end of some dimension of performance, whether this is to do with sight, hearing, reach or manipulation. Ergonomics, a discipline anchored on scientific data, regards human beings as the central focus of its operations and, consequently, offers various forms of support to applying universal design in product development. In this context, this paper sets out a reflection on applying the seven principles of universal design to fashion products and clothing with a view to targeting such principles as recommendations that will guide the early stages of developing these products, and establish strategies for market expansion, thereby increasing the volume of production and reducing prices.

Ergonomics and the inclusion of disabled people in the Brazilian job market.

The inclusion of persons with disabilities (PD) has been widely discussed in Brazil. The main purpose of this paper is to identify the contributions of ergonomics in the process of including disabled people in the job market and to discuss the situation in Brazil. It was found that ergonomics is an important tool within organizations. Using it allows space, work stations and tools to be matched workers' needs, including those with disabilities, on behalf of whom it is necessary to adjust the demands of work to their specific needs. However, further research is needed in Brazil on the existing methods of ergonomic intervention for this population in order to suit their needs and optimize potential.

Ergonomic intervention methods for inclusion of people with disabilities at work: Brazilian scene.

The aim is to identify ergonomic intervention methods used for including people with disabilities (PD) in the Brazilian labor market, with emphasis on discussion of methods to analyze the fit between the worker and the workplace. Methods to evaluate the fit of the worker to the workplace identify the capabilities and limitations of PDs and the demands of work, combining these data, and comparing them, in order to obtain a detailed analysis of the fit were drawn from national and international publications. These show that the use of specific methods for PDs and others focused on the general population. Mutatis mutandis, there is a need for complementary tools to address this segment. Thus, for the Brazilian scenario, it is essential to develop specific methodological tools to assess the capabilities of a PD so that they may better interact with their job.