RESUMEN
The effects of permanent darkness on proliferation of Ehrlich ascitic tumor cells and status of the chalone system in the tumor were studied. Chalone-containing preparations from animals exposed to different light conditions exhibited different biological effects on cell proliferation in this tumor. A relationship between biological activity of chalone-containing preparations and sensitivity of tumor cells to these preparations under conditions of modified photoregimen was revealed.
Asunto(s)
Carcinoma de Ehrlich/patología , Proliferación Celular , Luz , Animales , HumanosRESUMEN
We studied the influence of different photoregimens (light/darkness alternation and constant darkness) on the effect of saline and chalone regulation of cell proliferation in Ehrlich ascitic tumor was studied. Saline slightly inhibited proliferation of tumor cells. Chalone-containing preparations from animals exposed to light/darkness alternation and to constant darkness were characterized by different effects on cell proliferation in this tumor. Cell kinetics attested to possible mechanisms of the effect of the chalone system on the status of Ehrlich ascitic tumor; these mechanisms were independent on each other.
Asunto(s)
Carcinoma de Ehrlich/tratamiento farmacológico , Carcinoma de Ehrlich/patología , Chalonas/farmacología , Animales , Ciclo Celular , Proliferación Celular , Cinética , Luz , Masculino , Ratones , Mitosis , Cloruro de Sodio/farmacología , Factores de TiempoRESUMEN
The effect of changed photoperiod (constant darkness) on the proliferation of Ehrlich ascitic tumor cells was demonstrated. Some mechanisms maintaining the proliferative homeostasis in Ehrlich ascitic tumor under conditions of constant darkness were studied, explaining more leveled pattern of circadian rhythms of cell proliferation in animals kept under conditions of constant darkness and indicating the existence of circadian rhythm in sensitivity of Ehrlich ascitic tumor cell to permanent darkness.