[The state with the predominance of obsessive-compulsive disorders in the structure of childhood onset schizophrenia]. / Sostoianiia s preobladaniem obsessivno-kompul'sivnykh rasstroistv v strukture manifestiruiushchei v detskom vozraste shizofrenii.

Sixty inpatients, aged 7 to 15 years, with obsessive-compulsive disorders (OCD) have been examined. The inclusion criteria comprised diagnostic ICD-10 criteria for OCD (F42), schizophrenia childhood type (F20.83) and neurotic-like schizophrenia (F21.3). Patients with organic CNS disorder signs and marked somatic pathology were excluded from the study. According to clinical features of the disease and its course (disease progressiveness), three OCD types have been determined: OCD in the structure of affective and neurotic-like spectra disorders (type 1); OCD in the structure of paranoid spectrum disorders (type 2); OCD in the structure of states with prevail of "acquired" affective and negative disorders (type 3). Consideration of OCD types in childhood schizophrenia and the disease course allows to predict severity of negative changes and remissions that facilitates an adequate determination of the patients' adaptive potential.

[An experience of the application of rispolept in childhood schizophrenia]. / Opyt primeneniia preparata rispolept pri shizofrenii detskogo vozrasta.

The efficiency of rispolept was examined in open non-comparative study which included 32 patients 6.5-16 years of age with schizophrenic spectrum disorders. Efficiency of the drug was estimated by clinical psychopathologic method together with the evaluation according to the PANSS. 5 patients were additionally estimated according to the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) for the obsessive-compulsive disorders (a children version). The drug was used during 6 weeks in therapeutic doses from 4 to 8 mg/day. Reduction of the symptoms was 42% according to the PANNS for the positive items and 39% for the negative ones. There was also a significant decrease of manifestations of the obsessive-compulsive symptomatology according to CY-BOCS and of the depressive symptomatology according to the PANSS. Side effects comprised by vasotonic reactions (2 cases), oculomotor (2 cases) and torsion (one case) dyskinesias, which quickly disappeared after the correctors' administration. Extrapyramidal disorders were observed only after the increase of the dose up to 6-8 mg/day (3 cases). Results of the study have shown a high therapeutic efficiency of rispolept for childhood schizophrenia.