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1.
Blood Adv ; 8(5): 1179-1189, 2024 Mar 12.
Artículo en Inglés | MEDLINE | ID: mdl-38127271

RESUMEN

ABSTRACT: Advanced practice providers (APPs) are critical to the hematology workforce. However, there is limited knowledge about APPs in hematology regarding specialty-specific training, scope of practice, challenges and opportunities in APP-physician interactions, and involvement with the American Society of Hematology (ASH). We conducted APP and physician focus groups to elucidate major themes in these areas and used results to inform development of 2 national surveys, 1 for APPs and 1 for physicians who work with APPs. The APP survey was distributed to members of the Advanced Practitioner Society of Hematology and Oncology, and the physician survey was distributed to physician members of ASH. A total of 841 APPs and 1334 physicians completed the surveys. APPs reported most hematology-specific knowledge was obtained via on-the-job training and felt additional APP-focused training would be helpful (as did physicians). Nearly all APPs and physicians agreed that APPs were an integral part of their organizations and that physician-APP collaborations were generally positive. A total of 42.1% of APPs and 29.3% of physicians reported burnout, and >50% of physicians felt that working with APPs had reduced their burnout. Both physicians and APPs reported interest in additional resources including "best practice" guidelines for APP-physician collaboration, APP access to hematology educational resources (both existing and newly developed resources for physicians and trainees), and greater APP integration into national specialty-specific professional organizations including APP-focused sessions at conferences. Professional organizations such as ASH are well positioned to address these areas.


Asunto(s)
Hematología , Médicos , Humanos , Grupos Focales , Oncología Médica , Recursos Humanos
2.
J Am Coll Emerg Physicians Open ; 4(2): e12949, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37064163

RESUMEN

Objective: Income fairness is important, but there are limited data that describe income equity among emergency physicians. Understanding the magnitude of and factors associated with income differences may be helpful in eliminating disparities. This study analyzed the associations of demographic factors, training, practice setting, and board certification with emergency physician income. Methods: We distributed a survey to professional members of the American College of Emergency Physicians. The survey included questions on annual income, educational background, practice characteristics, gender, age, race, ethnicity, international medical graduate status, type of medical degree (MD vs DO), completion of a subspecialty fellowship, job characteristics, and board certification. Respondents also reported annual income. We used linear regression to determine the respondent characteristics associated with reported annual income. Results: From 45,961 members we received 3407 responses (7.4%); 2350 contained complete data for regression analysis. The mean reported annual income was $315,306 (95% confidence interval [CI], $310,649 to $319,964). The mean age of the respondents was 47.4 years, 37.4% were women, 3.2% were races underrepresented in medicine (Black, American Indian, or Alaskan Native), and 4.8% were Hispanic or Latino. On linear regression, female gender was associated with lower reported annual income; difference -$43,565, 95% CI, -$52,217 to -$34,913. Physician age, degree (MD vs DO), underrepresented racial minority status, and underrepresented ethnic minority status were not associated with annual income. Fellowship training was associated with lower income; Accreditation Council for Graduate Medical Education (ACGME) program difference -$30,048; 95% CI, -$48,183 to -$11,912, non-ACGME-program difference -$27,640, 95% CI, -$40,970 to -$14,257. Working at a for-profit institution was associated with higher income; difference $12,290, 95% CI, $3693 to $20,888. Board certification was associated with higher income; difference, $43,267, 95% CI, $30,767 to $55,767. Conclusions: This study identified income disparities associated with gender, practice setting, fellowship completion, and American Board of Emergency Medicine or American Osteopathic Board of Emergency Medicine certification.

3.
Blood Adv ; 7(13): 3058-3068, 2023 Jul 11.
Artículo en Inglés | MEDLINE | ID: mdl-35476017

RESUMEN

Burnout is prevalent throughout medicine. Few large-scale studies have examined the impact of physician compensation or clinical support staff on burnout among hematologists and oncologists. In 2019, the American Society of Hematology conducted a practice survey of hematologists and oncologists in the AMA (American Medical Association) Masterfile; burnout was measured using a validated, single-item burnout instrument from the Physician Work-Life Study, while satisfaction was assessed in several domains using a 5-point Likert scale. The overall survey response rate was 25.2% (n = 631). Of 411 respondents with complete responses in the final analysis, 36.7% (n = 151) were from academic practices and 63.3% (n = 260) from community practices; 29.0% (n = 119) were female. Over one-third (36.5%; n = 150) reported burnout, while 12.0% (n = 50) had a high level of burnout. In weighted multivariate logistic regression models incorporating numerous variables, compensation plans based entirely on relative value unit (RVU) generation were significantly associated with high burnout among academic and community physicians, while the combination of RVU + salary compensation showed no significant association. Female gender was associated with high burnout among academic physicians. High advanced practice provider utilization was inversely associated with high burnout among community physicians. Distinct patterns of career dissatisfaction were observed between academic and community physicians. We propose that the implementation of compensation models not based entirely on clinical productivity increased support for women in academic medicine, and expansion of advanced practice provider support in community practices may address burnout among hematologists and oncologists.


Asunto(s)
Agotamiento Profesional , Oncólogos , Médicos , Estados Unidos/epidemiología , Humanos , Femenino , Masculino , Satisfacción en el Trabajo , Agotamiento Profesional/epidemiología , Encuestas y Cuestionarios
5.
Blood Adv ; 3(21): 3278-3286, 2019 11 12.
Artículo en Inglés | MEDLINE | ID: mdl-31698456

RESUMEN

As the adult hematology and oncology fellowship training pathways have merged in the United States and concerns have arisen about the aging of practicing hematologists, the American Society of Hematology and hematology education leaders are looking to improve their understanding of the factors that contribute to fellows' plans to enter hematology-only careers. With the support of the American Society of Hematology, we collected and analyzed data from a survey of hematology/oncology fellows (n = 626) to examine the relationship between training and mentorship experiences and fellows' plans to enter hematology-only careers. Fellows who planned to enter hematology-only careers were significantly more likely to report having clinical training and mentorship experiences in hematology throughout their training relative to fellows with oncology-only or combined hematology/oncology career plans. After controlling for prior interest in hematology and demographic characteristics, exposure to hematology patients in medical school and fellowship, hematology research experiences, and hematology mentorship (research collaboration and career coaching) were positively and significantly associated with hematology-only career plans. These findings suggest that increasing opportunities for exposure to hematology patients, research opportunities and mentors throughout training could be helpful in building a strong pipeline of potential hematologists.


Asunto(s)
Selección de Profesión , Becas , Hematología/educación , Oncología Médica/educación , Mentores , Humanos , Modelos Logísticos , Encuestas y Cuestionarios
6.
Perspect Sex Reprod Health ; 50(2): 51-57, 2018 06.
Artículo en Inglés | MEDLINE | ID: mdl-29505114

RESUMEN

CONTEXT: Under the Affordable Care Act (ACA), the number of patients who have health insurance among those receiving family planning and reproductive health services at Title X-funded health centers has grown. However, billing some patients' insurance for services may be difficult because of Title X's extensive confidentiality protections. Little is known about health centers' experiences in addressing these difficulties. METHODS: Eight focus group discussions were conducted with a convenience sample of 54 Title X-funded health center staff members and state program administrators in January and April 2015. Transcripts were examined through thematic analysis. RESULTS: Participants identified five key barriers to centers' ability to bill patients' health insurance. Insurance providers' policyholder communications (e.g., explanations of benefits or patient portal postings) can threaten confidentiality for patients insured as dependents. Patients and providers are sometimes confused about insurance providers' confidentiality protections; centers are hesitant to bill insurance when protections are unclear. Changes in Medicaid family planning waiver coverage in some states have added to this uncertainty. Health centers can encounter significant administrative burdens when billing insurance while trying to protect patients' confidentiality. Finally, patients sometimes hesitate to use their insurance because of financial or other concerns. CONCLUSIONS: Title X-funded health centers face several barriers to their ability to bill patients' health insurance while maintaining confidentiality protections. As a result, they are likely to continue relying on Title X funds to cover services for some insured patients despite the expansion of health insurance under the ACA.


Asunto(s)
Personal Administrativo , Centros Comunitarios de Salud/economía , Confidencialidad/legislación & jurisprudencia , Servicios de Planificación Familiar/economía , Cobertura del Seguro , Reembolso de Seguro de Salud , Reclamos Administrativos en el Cuidado de la Salud/legislación & jurisprudencia , Comunicación , Centros Comunitarios de Salud/legislación & jurisprudencia , Seguridad Computacional , Femenino , Financiación Gubernamental , Grupos Focales , Humanos , Reembolso de Seguro de Salud/economía , Reembolso de Seguro de Salud/legislación & jurisprudencia , Medicaid/legislación & jurisprudencia , Prioridad del Paciente , Patient Protection and Affordable Care Act , Estados Unidos
7.
J Ambul Care Manage ; 40(1): 36-47, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-27902551

RESUMEN

This study investigated how years of experience with an electronic health record (EHR) related to productivity in community health centers (CHCs). Using data from the 2012 Uniform Data System, we regressed average annual medical visits, weighted for service intensity, as a function of full-time equivalent medical staff controlling for CHC size and location. Physician productivity significantly improved. Although the productivity of all other staff types was not significantly different by years of EHR experience, the trends showed lower productivity among nurses and other medical staff in CHCs with fewer years of EHR experience versus more years of experience.


Asunto(s)
Centros Comunitarios de Salud/organización & administración , Registros Electrónicos de Salud/organización & administración , Centros Comunitarios de Salud/normas , Centros Comunitarios de Salud/estadística & datos numéricos , Estudios Transversales , Eficiencia Organizacional/normas , Eficiencia Organizacional/estadística & datos numéricos , Registros Electrónicos de Salud/normas , Registros Electrónicos de Salud/estadística & datos numéricos , Humanos , Modelos Organizacionales , Encuestas y Cuestionarios , Factores de Tiempo
8.
Nurs Outlook ; 62(1): 39-45, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24345614

RESUMEN

Since the 1980s, U.S. policy makers have used immigration policy to influence the supply of nurses by allowing or restricting the entry of internationally educated nurses (IENs) into the U.S. workforce. The methods pursued have shifted over time from temporary visa categories in the 1980s and 1990s to permanent immigrant visas in the 2000s. The impact of policy measures adopted during nursing shortages has often been blunted by political and economic events, but the number and representation of IENs in the U.S. nursing workforce has increased substantially since the 1980s. Even as the United States seeks to increase domestic production of nurses, it remains a desirable destination for IENs and a target market for nurse-producing source countries. Hiring organizations and nurse leaders play a critical role in ensuring that the hiring and integration of IENs into U.S. health care organizations is constructive for nurses, source countries, and the U.S. health care system.


Asunto(s)
Emigración e Inmigración/historia , Emigración e Inmigración/legislación & jurisprudencia , Historia del Siglo XX , Historia del Siglo XXI , Enfermeras Internacionales , Enfermería , Estados Unidos , Recursos Humanos
9.
Health Policy Plan ; 28(1): 90-9, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22437505

RESUMEN

During the past few decades, the nursing workforce has been in crisis in the United States and around the world. Many health care organizations in developed countries recruit nurses from other countries to maintain acceptable staffing levels. The Philippines is the centre of a large, mostly private nursing education sector and an important supplier of nurses worldwide, despite its weak domestic health system and uneven distribution of health workers. This situation suggests a dilemma faced by developing countries that train health professionals for overseas markets: how do government officials balance competing interests in overseas health professionals' remittances and the need for well-qualified health professional workforces in domestic health systems? This study uses case studies of two recent controversies in nursing education and migration to examine how Philippine government officials represent nurses when nurse migration is the subject of debate. The study finds that Philippine government officials cast nurses as global rather than domestic providers of health care, implicating them in development more as sources of remittance income than for their potential contributions to the country's health care system. This orientation is motivated not simply by the desire for remittance revenues, but also as a way to cope with overproduction and lack of domestic opportunities for nurses in the Philippines.


Asunto(s)
Emigración e Inmigración/estadística & datos numéricos , Enfermeras y Enfermeros/provisión & distribución , Educación en Enfermería , Gobierno Federal , Humanos , Licencia en Enfermería , Enfermeras y Enfermeros/estadística & datos numéricos , Filipinas/epidemiología
10.
Nurs Econ ; 29(6): 308-16, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-22360105

RESUMEN

As the largest importer of internationally educated nurses (IENs), the United States is considered to be the epicenter of global nurse migration. The purposes of this study were to examine the geographic distribution of IEN hiring and determine associations between community and hospital characteristics and IEN hiring. More community characteristics than hospital characteristics were strongly associated with IEN hiring which suggest perceived community needs and receptivity to lENs could be an important consideration in hospital administrators' decisions to hire IENs. These findings suggest that as the U.S. population ages and becomes increasingly diverse, the demand for IENs is likely to grow. Nurse leaders and faculty may face challenges with regard to the ethical recruitment of IENs from low-income countries, incorporation of IENs into U.S. health care organizations, and continued development of a diverse U.S.-educated nursing workforce. This study expands understanding of the demand side of IEN employment in U.S. hospitals by providing the first in-depth examination of the community and hospital factors related to hospitals' IEN hiring.


Asunto(s)
Hospitales Comunitarios , Internacionalidad , Enfermeras y Enfermeros , Selección de Personal , Geografía , Estados Unidos , Recursos Humanos
11.
Soc Sci Med ; 71(1): 166-72, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20399550

RESUMEN

Exporting nurses has been a long-standing economic strategy for the Philippine government, despite the fact that the Philippines' domestic health system is weak and existing supplies of health workers are poorly distributed. This study explores the role of nursing schools as "migrant institutions" in expanding and commercializing nursing education and perpetuating the link between nursing education and migration. Data were collected primarily via in-depth interviews of key informants (nursing school administrators and policymakers) in the Philippines. Results suggest that nursing schools have expanded migration opportunities by making nursing educational available to more students and more diverse student populations. Also, some nursing schools have acted to control the licensure and recruitment processes by establishing commercial relationships with licensure exam review centers and recruitment agencies. These activities perpetuate the culture of migration in the country's nursing profession and indirectly contribute to declining quality of nursing education, misuse of scarce resources, corruption in the nursing sector, and exacerbation of existing health workforce imbalances.


Asunto(s)
Comercio , Educación en Enfermería/organización & administración , Emigración e Inmigración , Enfermeras y Enfermeros/provisión & distribución , Facultades de Enfermería/organización & administración , Humanos , Relaciones Interinstitucionales , Entrevistas como Asunto , Licencia en Enfermería , Cultura Organizacional , Selección de Personal , Filipinas , Facultades de Enfermería/economía
13.
Health Care Manage Rev ; 33(2): 178-87, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18360168

RESUMEN

BACKGROUND: Physician turnover threatens continuity of care for patients and is a huge expense for health care organizations. Health care organizations have been advised to help physicians build positive relations with colleagues, staff, and patients as a strategy to socially integrate physicians in the workplace and to increase physician retention. Although these recommendations are touted as "evidence-based" practices, the importance of workplace relationships for physician retention has not been established empirically. PURPOSE: The purpose of this study is to examine two questions: Are physicians who report better relationships with colleagues, staff, and patients less likely to intend to withdraw from practice? Do the effects of these relational factors differ for large-group and solo/small-group practice physicians? METHODOLOGY: Using data from the Physician Worklife Survey, we analyzed the associations between physicians' reported relationships with colleagues, staff, and patients and intention to withdraw from practice within 2 years using logistic regression. FINDINGS: : Relationships with colleagues had a significant and negative association with intended withdrawal from practice for large-group practice physicians. The joint effect of relationships with colleagues, staff, and patients was significant for large-group practice physicians, but it only approached significance for solo/small-group practice physicians. PRACTICE IMPLICATIONS: This study suggests that workplace relationships may influence physicians' intention to withdraw from practice, but the mechanisms by which they do so are unclear. Possible interventions to improve physician retention include promotion of informal mentoring and efforts to support community involvement of physicians and their families. Further research examining the role of these and other programs in promoting physician retention can help employers to foster positive workplace relationships and improve retention.


Asunto(s)
Intención , Relaciones Interprofesionales , Lealtad del Personal , Médicos/psicología , Lugar de Trabajo , Adulto , Femenino , Práctica de Grupo , Encuestas de Atención de la Salud , Humanos , Satisfacción en el Trabajo , Modelos Logísticos , Masculino , Persona de Mediana Edad , Reorganización del Personal/economía , Práctica Privada , Estados Unidos
14.
Am J Med ; 118(12): 1416, 2005 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16378797

RESUMEN

PURPOSE: Although Staphylococcus aureus is a leading cause of nosocomial infection, little is known about the impact of S. aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses. SUBJECTS AND METHODS: All hospitalized patients with a prosthetic device and S. aureus bacteremia during the 96-month study period were identified prospectively. Clinical data were collected at the time of hospitalization. Data regarding infection-related resource utilization and infection-related costs within 12 weeks of the initial bacteremia were also recorded. RESULTS: 298 patients with > or =1 prosthesis and S. aureus bacteremia were identified (cardiovascular device--122 patients, orthopedic device--73 patients, long-term catheter--71 patients, and other devices-32 patients). Overall, 58% of patients underwent surgery as a consequence of the infection. Infection-related complications occurred in 41% and the overall 12-week mortality was 27%. The mean infection-related cost was 67439 dollars for patients with hospital-acquired S. aureus bacteremia and 37868 dollars for community-acquired S. aureus bacteremia (cost difference 29571 dollars; 95% confidence interval, 14370 dollars-49826 dollars). Rates of device infection, complications, 12-week mortality, and mean cost varied by prosthesis type. CONCLUSION: S. aureus bacteremia in patients with prosthetic devices is associated with frequent complications, substantial cost, and significant health care resource utilization.


Asunto(s)
Bacteriemia/economía , Bacteriemia/etiología , Costos de la Atención en Salud/estadística & datos numéricos , Prótesis e Implantes/efectos adversos , Infecciones Estafilocócicas/economía , Infecciones Estafilocócicas/etiología , Adulto , Anciano , Infección Hospitalaria , Femenino , Servicios de Salud/estadística & datos numéricos , Humanos , Pacientes Internos , Masculino , Persona de Mediana Edad , Evaluación de Resultado en la Atención de Salud , Estudios Retrospectivos , Staphylococcus aureus/patogenicidad
15.
Am Heart J ; 150(2): 323-9, 2005 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-16086938

RESUMEN

BACKGROUND: In a multinational clinical trial, valsartan was statistically not inferior to captopril in reducing mortality and cardiovascular morbidity after myocardial infarction (MI) in patients with signs of heart failure and/or left ventricular dysfunction. We conducted a prospective economic evaluation to compare within-trial resource use, costs, and quality of life in patients receiving valsartan, captopril, or both after MI. METHODS: We assigned country-specific unit costs to resource use data for 14703 patients and measured health-related quality of life in a subset of 4524 patients. We used the nonparametric bootstrap method to compare rates of resource use and costs, and a piecewise linear mixed-effects regression analysis to compare longitudinal measures of quality of life. RESULTS: There were no significant differences in rates of resource use between the valsartan and captopril groups. During an average follow-up of 2 years, total costs for patients receiving valsartan were significantly higher than for patients receiving captopril (USD 14103 vs USD 13038; 95% CI USD 369-USD 1875). The cost differential was caused primarily by the cost of the study medications (USD 1056 for valsartan vs USD 165 for captopril; 95% CI USD 867 to USD 912). Quality of life did not differ significantly between groups. CONCLUSIONS: For most patients at high risk after MI, the availability of generic captopril confers a cost advantage over valsartan because of lower medication costs. The difference will be smaller or nonexistent in settings where brand-name ACE inhibitors are prescribed.


Asunto(s)
Bloqueadores del Receptor Tipo 1 de Angiotensina II/uso terapéutico , Recursos en Salud/estadística & datos numéricos , Infarto del Miocardio/tratamiento farmacológico , Tetrazoles/uso terapéutico , Valina/análogos & derivados , Atención Ambulatoria/economía , Atención Ambulatoria/estadística & datos numéricos , Inhibidores de la Enzima Convertidora de Angiotensina/economía , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Captopril/economía , Captopril/uso terapéutico , Costos de los Medicamentos , Salud Global , Costos de la Atención en Salud , Recursos en Salud/economía , Insuficiencia Cardíaca/tratamiento farmacológico , Insuficiencia Cardíaca/economía , Insuficiencia Cardíaca/etiología , Costos de Hospital , Hospitalización/economía , Hospitalización/estadística & datos numéricos , Humanos , Infarto del Miocardio/complicaciones , Infarto del Miocardio/economía , Infarto del Miocardio/psicología , Estudios Prospectivos , Calidad de Vida , Valina/uso terapéutico , Valsartán , Disfunción Ventricular Izquierda/tratamiento farmacológico , Disfunción Ventricular Izquierda/economía , Disfunción Ventricular Izquierda/etiología
16.
Arch Pediatr Adolesc Med ; 159(4): 362-6, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15809391

RESUMEN

BACKGROUND: Use of atypical antipsychotic medications in pediatric populations is increasing. Although previous studies have presented data by age or sex, none has documented sex-specific prevalence by age group. OBJECTIVE: To estimate the 1-year prevalence of atypical antipsychotic use by age and sex among commercially insured youths in the United States. DESIGN: Period prevalence study, January through December 2001. SETTING: Administrative claims database of a large pharmaceutical benefit manager for 6 213 824 outpatients. MAIN OUTCOME MEASURES: Period prevalence of outpatient prescription claims for atypical antipsychotic drugs among commercially insured, continuously enrolled youths. RESULTS: The prevalence of atypical antipsychotic use was 267.1 per 100 000 subjects aged 19 years and younger (16 599/6 213 824) and was more than twice as high for male patients as for female patients, although male and female patients were nearly equally represented in the overall population. Prevalence peaked at 594.3 per 100 000 subjects among male patients aged 10 to 14 years and 291.0 per 100 000 subjects among female patients aged 15 to 19 years. Nearly one fourth (3830/16 599) of patients with a claim for an atypical antipsychotic were aged 9 years and younger, and nearly 80% of these (3021/3830) were boys. CONCLUSIONS: Although evidence regarding the safety and efficacy of atypical antipsychotics in young children is limited, nearly one fourth of patients with claims for these drugs were aged 9 years or younger, and a large majority of these were boys. Understanding the long-term effects on the developing brain of early and prolonged exposure to atypical antipsychotics is crucial given their use in pediatric populations.


Asunto(s)
Antipsicóticos/uso terapéutico , Adolescente , Adulto , Factores de Edad , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Seguro de Servicios Farmacéuticos/estadística & datos numéricos , Masculino , Factores Sexuales
17.
Health Aff (Millwood) ; 24(1): 220-7, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15647233

RESUMEN

This study assesses six states' allocation decisions for funds from tobacco settlement agreements, using information from newspaper articles and other public sources. State allocation decisions were diverse; substantial shares were allocated to areas other than tobacco control and health, including capital projects and budget shortfalls. The allocations did not reflect the stated goals of the lawsuits leading to the settlements. This outcome reflects a lack of strong advocacy from public health interest groups, an unreliable public constituency for tobacco control, and inconsistent support from state executive and legislative branches, all combined with sizable budget deficits that provided competing uses for settlement funds.


Asunto(s)
Asignación de Costos , Gastos en Salud , Política Pública , Industria del Tabaco/legislación & jurisprudencia , Industria del Tabaco/economía , Estados Unidos
18.
Pharmacoepidemiol Drug Saf ; 14(6): 407-15, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15372671

RESUMEN

PURPOSE: Previous research has suggested an association between use of atypical antipsychotics and onset of diabetes mellitus. We sought to compare the incidence of new onset diabetes among patients receiving atypical antipsychotics, traditional antipsychotics or antidepressants. METHODS: Retrospective cohort study of outpatients with claims for atypical antipsychotics (n = 10 265) compared to controls with claims for traditional antipsychotics (n = 4607), antidepressants (n = 60 856) or antibiotics (n = 59 878) in the administrative claims database of a large pharmaceutical benefit manager between June 2000 and May 2002. Main outcome measures were adjusted and unadjusted incidence rates of diabetes (new cases per 1000 per year) in a 12-month period, as measured using new prescriptions for antidiabetic drugs after a 6-month lead-in period. RESULTS: Annual unadjusted incidence rates of diabetes (new cases per 1000 per year) were 7.5 for atypical antipsychotics, 11.3 for traditional antipsychotics, 7.8 for antidepressants and 5.1 for antibiotics. In multivariable analyses, age, male sex and Chronic Disease Score were associated with greater odds of diabetes onset. There were no statistically significant differences in outcome between the atypical antipsychotic, traditional antipsychotic and antidepressant groups. Multivariable comparisons among specific agents showed increased odds of diabetes for clozapine, olanzapine, ziprasidone and thioridazine (relative to risperidone), but these comparisons did not reach statistical significance. CONCLUSIONS: In a large prescription claims database, outpatients taking atypical antipsychotics did not have higher rates of diabetes onset, compared to subjects taking traditional antipsychotics or antidepressants.


Asunto(s)
Antipsicóticos/uso terapéutico , Diabetes Mellitus/inducido químicamente , Pacientes Ambulatorios/estadística & datos numéricos , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Antibacterianos/efectos adversos , Antibacterianos/uso terapéutico , Antidepresivos/efectos adversos , Antidepresivos/uso terapéutico , Antipsicóticos/efectos adversos , Benzodiazepinas/efectos adversos , Benzodiazepinas/uso terapéutico , Clozapina/efectos adversos , Clozapina/uso terapéutico , Estudios de Cohortes , Bases de Datos Factuales , Diabetes Mellitus/epidemiología , Dibenzotiazepinas/efectos adversos , Dibenzotiazepinas/uso terapéutico , Prescripciones de Medicamentos/estadística & datos numéricos , Femenino , Humanos , Incidencia , Formulario de Reclamación de Seguro/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Olanzapina , Piperazinas/efectos adversos , Piperazinas/uso terapéutico , Fumarato de Quetiapina , Estudios Retrospectivos , Risperidona/efectos adversos , Risperidona/uso terapéutico , Factores Sexuales , Tiazoles/efectos adversos , Tiazoles/uso terapéutico , Tioridazina/efectos adversos , Tioridazina/uso terapéutico , Factores de Tiempo , Estados Unidos/epidemiología
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