RESUMEN
Objective: We present a case of multiple tumefactive demyelinating lesions (TDLs) emerging 24 months after the second cycle of alemtuzumab treatment. Methods: A woman with relapsing-remitting multiple sclerosis (MS) discontinued fingolimod treatment due to gestational desire, which resulted in a severe disease exacerbation. Alemtuzumab was initiated, accompanied by regular clinical, radiological, and immunological monitoring. Results: She relapsed prior to the second cycle, exhibiting 12 T1Gd+ lesions, and peripheral blood showed an increase in B-cells and a decrease in T-cells. At 24 months following the second cycle, she developed cognitive impairment and multiple T1Gd+ lesions, including TDLs, were evident on the brain MRI. We found not only an increase in B-cells but also in Th1 central memory cells. Th1/Th17 cells increased 3 months before the detection of TDLs. Conclusions: TDLs can appear 24 months after the second cycle of alemtuzumab treatment in MS. The increase in Th1/Th17 cells could be a candidate biomarker for TDLs in alemtuzumab-treated MS patients.
Asunto(s)
Alemtuzumab , Biomarcadores , Imagen por Resonancia Magnética , Esclerosis Múltiple Recurrente-Remitente , Humanos , Alemtuzumab/efectos adversos , Alemtuzumab/uso terapéutico , Femenino , Adulto , Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico , Esclerosis Múltiple Recurrente-Remitente/inmunología , Células Th17/inmunología , Células TH1/inmunología , Linfocitos B/inmunología , Linfocitos B/efectos de los fármacos , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Encéfalo/inmunologíaRESUMEN
No disponible