Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 45
Filtrar
1.
Nat Commun ; 15(1): 2187, 2024 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-38467617

RESUMEN

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p < 0.001) and animal models (p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance (p < 0.0001) and distensibility (p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries.


Asunto(s)
Prótesis Vascular , Calcinosis , Ovinos , Animales , Estudios Retrospectivos , Calcinosis/cirugía , Materiales Biocompatibles , Politetrafluoroetileno
2.
Vet Med Sci ; 9(1): 68-75, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36408760

RESUMEN

BACKGROUND: Surgical interventions are recommended for cases of advanced mitral regurgitation, however, limited facilities are available. The most prominent complication in such procedures is heparin-derived bleeding. An alternative anticoagulant to heparin, nafamostat mesilate (NM), can reduce the occurrence of complications associated with heparin such as bleeding or shock. OBJECTIVES: This study aimed to evaluate the utility and safety of using NM during anaesthesia in canines. METHODS: Six healthy adult Beagle dogs were anaesthetised, and NM was administered intravenously as a 10 mg/kg bolus dose over 5 min, followed by a continuous infusion of 10 mg/kg/h over 20 min. Blood tests and blood pressure measurements were performed at 0, 5, 25 and 55 min after NM administration. RESULTS: Activated thromboplastin times at 0, 25 and 55 min were 13.0 ± 0.7 s, 106.7 ± 13.3 s and 28.2 ± 2.9 s, respectively, with a significant difference between 0 and 25 min (p < 0.01) only. No significant differences were observed in prothrombin time, antithrombin, fibrinogen and fibrin degradation product concentrations between timepoints. Activated clotting times (ACTs) at 0, 5, 25 and 55 min were 119.5 ± 9.6 s, 826.7 ± 78.6 s, 924.8 ± 42.4 s and 165.2 ± 13.5 s, respectively. Significant differences were observed between 0 and 5 min (p < 0.05) and between 0 and 25 min (p < 0.05). Blood pressure changes occurred in four dogs (66.7%). No other serious adverse effects were observed. CONCLUSIONS: ACT results indicated that NM use in anaesthetised healthy dogs was sufficient to obtain procedural anticoagulation with minimal adverse effects. However, these preliminary data require validation in further studies on cardiopulmonary bypass surgery.


Asunto(s)
Anticoagulantes , Heparina , Perros , Animales , Anticoagulantes/efectos adversos , Guanidinas/efectos adversos , Benzamidinas
3.
J Cardiothorac Surg ; 17(1): 111, 2022 May 11.
Artículo en Inglés | MEDLINE | ID: mdl-35546242

RESUMEN

OBJECTIVE: The objective of this study was to evaluate the long-term surgical results of transposition of the great arteries with left ventricular outflow tract obstruction. METHODS: We conducted a retrospective study of patients with transposition of the great arteries or double outlet right ventricle with left ventricular outflow tract obstruction undergoing biventricular repair between 1980 and 2017. RESULTS: One hundred and eleven patients were enrolled and classified into five groups: atrial switch (n = 20), arterial switch (n = 12), Nikaidoh (n = 7), Rastelli (n = 48), and REV operation groups (n = 24). Early mortality was highest in Nikaidoh group (29%). Median follow-up was 18.2 years. Long-term survival was by far lowest in Nikaidoh group and comparable among the other 4 groups. Freedom from reoperation at 20 years was lowest in Rastelli group (32.1%) due to right ventricular outflow tract-related reoperations. While having no recurrence of left ventricular outflow tract obstruction, the arterial switch operation group had a high proportion of substantial neo-aortic regurgitation (29%). CONCLUSIONS: The long-term survival was satisfactory regardless of the surgical technique except Nikaidoh group. The surgical option for transposition of the great arteries with left ventricular outflow tract obstruction should be selected based on the features of the respective procedures.


Asunto(s)
Operación de Switch Arterial , Cardiopatías Congénitas , Transposición de los Grandes Vasos , Obstrucción del Flujo Ventricular Externo , Operación de Switch Arterial/métodos , Arterias , Estudios de Seguimiento , Humanos , Lactante , Estudios Retrospectivos , Transposición de los Grandes Vasos/cirugía , Resultado del Tratamiento , Obstrucción del Flujo Ventricular Externo/cirugía
4.
PLoS One ; 17(4): e0267274, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35436313

RESUMEN

We previously developed a non-cell-dependent biodegradable scaffold to create in situ tissue-engineered vasculature (iTEV) and tested it in a canine inferior vena cava (IVC) model. As iTEV features change dramatically during tissue generation, practical, simple, and accurate methods to evaluate iTEV are needed. The present study examined the usefulness of a novel method to evaluate iTEV growth and remodeling according to a simple formula using angiography: hepatic vein (HV) index = (IVC-HV junction angle) ÷ (π × [minimal internal iTEV diameter ÷ 2]2). HV index strongly correlated with the pressure gradient across iTEV, which tended to improve during the tissue generation period up to 12 months post-implantation. Time-course changes in HV index reflected iTEV tissue development and in-vivo characteristics, such as hemodynamic congestion. In conclusion, HV index is useful to assess iTEV graft function because it represents both the morphometrics and hemodynamics of iTEV with only diagnostic imaging data.


Asunto(s)
Ingeniería de Tejidos , Vena Cava Inferior , Animales , Perros , Crecimiento y Desarrollo , Venas Hepáticas/diagnóstico por imagen , Ingeniería de Tejidos/métodos , Vena Cava Inferior/diagnóstico por imagen
5.
World J Pediatr Congenit Heart Surg ; 12(4): 508-515, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-34278861

RESUMEN

BACKGROUND: The purpose of this study was to assess autograft function after the Ross procedure and to review surgical outcomes associated with autograft reoperations. METHODS: This is a retrospective study of patients undergoing the Ross procedure since 1993. Autograft function and autograft reoperation were studied. Autograft failure was defined as more than moderate autograft regurgitation or autograft dilatation to more than 50 mm diameter or z-score of more than +4 in children. One hospital death was excluded from analysis as were patients with unknown late autograft status. RESULTS: Among 75 patients analyzed, preoperative diagnosis before the Ross procedure included aortic regurgitation in 26, aortic stenosis in 19, combined lesions in 28, and 2 mechanical valve malfunctions. Median age at the Ross procedure was 12.1 (0.4-43.6) years with 44 children less than 15 years old. Six patients had greater than mild autograft regurgitation at post-Ross hospital discharge. During median follow-up of 14.9 years, there were 23 autograft failures. Eighteen autograft reoperations were performed on 17 patients (13 children), including 12 aortic valve replacements, 5 aortic root replacements (including 1 valve-sparing root replacement), and 1 Konno procedure. Freedom from autograft failure and autograft reoperation at 20 years after the Ross procedure was 52.0% and 66.3%, respectively. Multivariate analysis identified greater than mild autograft regurgitation at hospital discharge from Ross procedure as a risk factor for autograft failure (P < .01). All patients who underwent autograft reoperation survived and had good health status at a median of 6.9 years after the reoperation. CONCLUSIONS: The Ross procedure is effective in delaying prosthetic aortic valve replacement, although the time-related risk of autograft failure is a real consideration.


Asunto(s)
Insuficiencia de la Válvula Aórtica , Estenosis de la Válvula Aórtica , Válvula Pulmonar , Adolescente , Válvula Aórtica/cirugía , Insuficiencia de la Válvula Aórtica/cirugía , Estenosis de la Válvula Aórtica/cirugía , Autoinjertos , Niño , Estudios de Seguimiento , Humanos , Válvula Pulmonar/cirugía , Reoperación , Estudios Retrospectivos , Trasplante Autólogo , Resultado del Tratamiento
6.
J Card Surg ; 36(3): 821-827, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33522620

RESUMEN

OBJECTIVES: The objective of this study was to compare the long-term surgical results of anomalous origin of the left coronary artery (LCA) from the pulmonary artery repair between infants and older patients. METHODS: This is a retrospective study of patients undergoing anomalous origin of the LCA from the pulmonary artery repair between 1982 and 2018. RESULTS: Thirty-five patients were enrolled and divided into two groups based on their age: infants (<1 year of age: n = 11) and older patients (>1 year of age: n = 24). Median age was 5.2 months in infants and 6.3 years in older patients. The procedure included 24 LCA implantations and 11 intrapulmonary baffle repairs. Early mortality was recorded only in two infants (18%). Early complications included two low output syndrome (18%). Survival and freedom from reoperation at median follow-up of 17.2 years were not significantly different between groups (survival, 81.8 ± 11.6% vs. 94.1 ± 5.7% [p = .3846]; freedom from reoperation, 77.8 ± 13.9% vs. 90.0 ± 6.8% [p = .1175]). Mitral regurgitation (MR) developed substantially in two older patients in the long-term. In infants, significant improvements of fractional shortening (p = .0252) and left ventricular (LV) end-systolic (p = .0142) and end-diastolic diameter (p = .0157) occurred at 1 month. CONCLUSIONS: Although there was no significant difference in survival and reoperation rate, the postoperative LV remodeling occurred more evident and rapid in infants. Worsening of MR in the long-term was observed only in older patients.


Asunto(s)
Anomalías de los Vasos Coronarios , Insuficiencia de la Válvula Mitral , Adulto , Anciano , Niño , Anomalías de los Vasos Coronarios/cirugía , Humanos , Lactante , Insuficiencia de la Válvula Mitral/cirugía , Arteria Pulmonar/diagnóstico por imagen , Arteria Pulmonar/cirugía , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
7.
Gen Thorac Cardiovasc Surg ; 69(1): 27-31, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32686032

RESUMEN

OBJECTIVE: To investigate mid- to long-term morbidity and mortality after the repair of partial anomalous pulmonary venous connections (PAPVCs). METHODS: We retrospectively analyzed the cases of 29 consecutive patients who underwent surgery in 1991-2010 at Tokyo Women's Medical University Hospital. Median follow-up period: 9.9 years. Median age at operation: 7.4 years. Median body weight: 22.4 kg. Right PAPVC (n = 23), left-PAPVC (n = 5), and mixed PAPVC (n = 1) were identified. RESULTS: In the 14 patients with a right upper pulmonary vein (PV) connected to the superior vena cava (SVC) and/or cavo-atrial junction, the following were performed: single-patch diversion (n = 6), double-patch diversion (n = 4), Warden procedure (n = 1), and atrial septation with the atrial wall (n = 3). In the nine patients with a right anomalous PV connected to the right atrium (RA) and/or coronary sinus, intra-atrial rerouting was performed (n = 7) and translocation of the atrial septum (n = 2). Intra-atrial rerouting of the left upper and lower PVs to the coronary sinus (n = 1) and direct anastomosis of the left upper PV to the left atrial appendage (n = 4) were performed. Double-patch diversion and direct anastomosis of the left upper PV to the left atrial appendage was performed in a patient with mixed PAPVC. There were no post-operative deaths or reoperations, although transient sinus node dysfunction occurred (n = 2 with atrial septation and intra-atrial rerouting), while mild stenosis of the SVC occurred (n = 1 with double-patch diversion). CONCLUSIONS: The various methods which we used for PAPVC repair all appear to have reasonable outcomes, although rhythm disturbance and stenotic complications were confirmed in a few patients.


Asunto(s)
Venas Pulmonares , Síndrome de Cimitarra , Femenino , Humanos , Venas Pulmonares/cirugía , Estudios Retrospectivos , Síndrome de Cimitarra/diagnóstico por imagen , Síndrome de Cimitarra/cirugía , Resultado del Tratamiento , Vena Cava Superior/diagnóstico por imagen , Vena Cava Superior/cirugía
8.
Sci Transl Med ; 12(537)2020 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-32238576

RESUMEN

We developed a tissue-engineered vascular graft (TEVG) for use in children and present results of a U.S. Food and Drug Administration (FDA)-approved clinical trial evaluating this graft in patients with single-ventricle cardiac anomalies. The TEVG was used as a Fontan conduit to connect the inferior vena cava and pulmonary artery, but a high incidence of graft narrowing manifested within the first 6 months, which was treated successfully with angioplasty. To elucidate mechanisms underlying this early stenosis, we used a data-informed, computational model to perform in silico parametric studies of TEVG development. The simulations predicted early stenosis as observed in our clinical trial but suggested further that such narrowing could reverse spontaneously through an inflammation-driven, mechano-mediated mechanism. We tested this unexpected, model-generated hypothesis by implanting TEVGs in an ovine inferior vena cava interposition graft model, which confirmed the prediction that TEVG stenosis resolved spontaneously and was typically well tolerated. These findings have important implications for our translational research because they suggest that angioplasty may be safely avoided in patients with asymptomatic early stenosis, although there will remain a need for appropriate medical monitoring. The simulations further predicted that the degree of reversible narrowing can be mitigated by altering the scaffold design to attenuate early inflammation and increase mechano-sensing by the synthetic cells, thus suggesting a new paradigm for optimizing next-generation TEVGs. We submit that there is considerable translational advantage to combined computational-experimental studies when designing cutting-edge technologies and their clinical management.


Asunto(s)
Prótesis Vascular , Constricción Patológica , Ingeniería de Tejidos , Animales , Niño , Constricción Patológica/terapia , Humanos , Ovinos , Estados Unidos
9.
Ann Thorac Surg ; 108(4): 1210-1216, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31077656

RESUMEN

BACKGROUND: The purpose of this study is to assess risk factors of neo-aortic regurgitation (AR) after an arterial switch operation and outcomes of neo-aortic valve surgery. METHODS: This is a retrospective study of 469 hospital survivors after arterial switch operation from 1982 to 2016. Preoperative diagnoses included 285 transpositions of the great arteries with intact septum, 140 transpositions with ventricular septal defect, and 44 double-outlet right ventricles. More than mild preoperative pulmonary regurgitation was found in 15 patients. Median age at the operation was 1.0 months (range, 0.1-81.5). Concomitant relief of left ventricular outflow tract obstruction was performed in 20 patients. Seventy-seven patients had more than mild neo-AR at hospital discharge. RESULTS: More than moderate neo-AR was found in 41 patients (8.6%) at a median follow-up of 19.0 years (range, 0.1-35.2). Multivariate analysis identified more than mild preoperative pulmonary regurgitation, concomitant relief of left ventricular outflow tract obstruction, and more than mild neo-AR at hospital discharge as risk factors for late neo-AR. Seventeen patients (3.6%) underwent neo-aortic valve surgeries, including 11 aortic valve replacements, 3 aortic valve plasties, 2 Konno procedures, and 1 aortic root replacement, with median age at the neo-aortic valve surgery of 16.5 years (range, 6.2-27.3). There were 2 late deaths and 5 reoperations to the neo-aortic valve in 4 patients. CONCLUSIONS: Concomitant relief of left ventricular outflow tract obstruction and preoperative more than mild pulmonary regurgitation increase the risk of neo-AR after the arterial switch operation. Reoperation for neo-AR can be done safely.


Asunto(s)
Insuficiencia de la Válvula Aórtica/epidemiología , Operación de Switch Arterial/efectos adversos , Ventrículo Derecho con Doble Salida/cirugía , Defectos del Tabique Interventricular/cirugía , Transposición de los Grandes Vasos/cirugía , Adolescente , Niño , Preescolar , Ventrículo Derecho con Doble Salida/complicaciones , Femenino , Defectos del Tabique Interventricular/complicaciones , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Insuficiencia de la Válvula Pulmonar/complicaciones , Insuficiencia de la Válvula Pulmonar/cirugía , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Transposición de los Grandes Vasos/complicaciones , Obstrucción del Flujo Ventricular Externo/complicaciones , Obstrucción del Flujo Ventricular Externo/cirugía , Adulto Joven
10.
World J Pediatr Congenit Heart Surg ; 9(2): 150-156, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29544411

RESUMEN

BACKGROUND: Japan Congenital Cardiovascluar Surgical Database (JCCVSD) is a nationwide registry whose data are used for health quality assessment and clinical research in Japan. We evaluated the completeness of case registration and the accuracy of recorded data components including postprocedural mortality and complications in the database via on-site data adjudication. METHODS: We validated the records from JCCVSD 2010 to 2012 containing congenital cardiovascular surgery data performed in 111 facilities throughout Japan. We randomly chose nine facilities for site visit by the auditor team and conducted on-site data adjudication. We assessed whether the records in JCCVSD matched the data in the source materials. RESULTS: We identified 1,928 cases of eligible surgeries performed at the facilities, of which 1,910 were registered (99.1% completeness), with 6 cases of duplication and 1 inappropriate case registration. Data components including gender, age, and surgery time (hours) were highly accurate with 98% to 100% concordance. Mortality at discharge and at 30 and 90 postoperative days was 100% accurate. Among the five complications studied, reoperation was the most frequently observed, with 16 and 21 cases recorded in the database and source materials, respectively, having a sensitivity of 0.67 and a specificity of 0.99. CONCLUSIONS: Validation of JCCVSD database showed high registration completeness and high accuracy especially in the categorical data components. Adjudicated mortality was 100% accurate. While limited in numbers, the recorded cases of postoperative complications all had high specificities but had lower sensitivity (0.67-1.00). Continued activities for data quality improvement and assessment are necessary for optimizing the utility of these registries.


Asunto(s)
Exactitud de los Datos , Bases de Datos Factuales/normas , Cardiopatías Congénitas/cirugía , Complicaciones Posoperatorias , Sistema de Registros/normas , Bases de Datos Factuales/estadística & datos numéricos , Cardiopatías Congénitas/mortalidad , Humanos , Japón/epidemiología , Mejoramiento de la Calidad , Sistema de Registros/estadística & datos numéricos
11.
Semin Thorac Cardiovasc Surg ; 30(2): 175-179, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29427773

RESUMEN

Tissue engineering holds great promise for the advancement of cardiovascular surgery as well as other medical fields. Tissue-engineered vascular grafts have the ability to grow and remodel and could therefore make great advances for pediatric cardiovascular surgery. In 2001, we began a human clinical trial evaluating these grafts in patients with a univentricular physiology. Herein, we report the long-term results of patients who underwent implantation of tissue-engineered vascular grafts as extracardiac total cavopulmonary conduits. Tissue-engineered vascular grafts seeded with autologous bone marrow mononuclear cells were implanted in 25 patients with univentricular physiology. The graft is composed of a woven fabric of poly-l-lactide acid or polyglycolic acid and a 50:50 poly (l-lactic-co-ε-caprolactone) copolymer. Patients were followed up with postoperatively in a multidisciplinary clinic. Median patient age at operation was 5.5 years and the mean follow-up period was 11.1 years. There was no graft-related mortality during the follow-up period. There was also no evidence of aneurysmal formation, graft rupture, graft infection, or calcification. Seven (28%) patients had asymptomatic graft stenosis and underwent successful balloon angioplasty. Stenosis is the primary complication of the tissue-engineered vascular graft. Avoidance of anticoagulation therapy would improve patients' quality of life. Tissue-engineered vascular grafts have feasibility in pediatric cardiovascular surgery.


Asunto(s)
Bioprótesis , Implantación de Prótesis Vascular/instrumentación , Prótesis Vascular , Procedimiento de Fontan/instrumentación , Cardiopatías Congénitas/cirugía , Trasplante de Células Madre/métodos , Ingeniería de Tejidos/métodos , Andamios del Tejido , Vena Cava Inferior/cirugía , Adolescente , Factores de Edad , Angioplastia de Balón , Implantación de Prótesis Vascular/efectos adversos , Niño , Preescolar , Angiografía por Tomografía Computarizada , Estudios de Factibilidad , Femenino , Estudios de Seguimiento , Procedimiento de Fontan/efectos adversos , Oclusión de Injerto Vascular/diagnóstico por imagen , Oclusión de Injerto Vascular/fisiopatología , Oclusión de Injerto Vascular/terapia , Cardiopatías Congénitas/diagnóstico por imagen , Cardiopatías Congénitas/fisiopatología , Humanos , Lactante , Masculino , Poliésteres/química , Diseño de Prótesis , Calidad de Vida , Trasplante de Células Madre/efectos adversos , Factores de Tiempo , Resultado del Tratamiento , Grado de Desobstrucción Vascular , Vena Cava Inferior/diagnóstico por imagen , Vena Cava Inferior/fisiopatología , Adulto Joven
12.
Semin Thorac Cardiovasc Surg ; 29(2): 215-220, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28823332

RESUMEN

We investigated the effect of ventricular septal defect (VSD) enlargement on long-term surgical results, late arrhythmia, and left ventricular (LV) function in the Rastelli procedure for D-transposition of the great arteries with LV outflow tract obstruction (LVOTO). From 1979 to 2001, 74 patients (D-transposition of the great arteries, n = 56; double outlet right ventricle, n = 18) underwent the Rastelli procedure. In group A, 46 patients underwent the Rastelli procedure with VSD enlargement, and in group B, 28 patients underwent the Rastelli procedure without enlargement. There were no hospital deaths. Actuarial survival at 20 years was 80% in group A and 91% in group B (P = 0.50). Freedom from reoperations at 20 years was 40.1% in group A and 52.0% in group B. Reoperations for LVOTO were performed in 2 patients in both groups. In postoperative catheterization, LV ejection fraction in group A was 57.1% ± 8.7% vs 57.2% ± 8.1% in group B (P = 0.97); LV end-diastolic volume, 150.0% ± 47.2% vs 142.0% ± 36.9% of the normal volume (P = 0.97). In long-term postoperative echocardiography, the pressure gradient of the LV to the aorta was 12.0 ± 12.8 vs 17.7 ± 26.0 mm Hg in groups A and B (P = 0.31). There were no differences between the groups regarding basal rhythms, anti-arrhythmic agents, and pacemaker implantation rate. VSD enlargement in the Rastelli procedure can be safely performed without early mortality and with long-term low mortality and morbidity regarding arrhythmia, LV function, and reoperation for late LVOTO. VSD enlargement should be considered as an option for avoiding long-term LVOTO.


Asunto(s)
Operación de Switch Arterial , Defectos del Tabique Interventricular/cirugía , Transposición de los Grandes Vasos/cirugía , Adolescente , Adulto , Antiarrítmicos/uso terapéutico , Arritmias Cardíacas/etiología , Arritmias Cardíacas/fisiopatología , Arritmias Cardíacas/terapia , Operación de Switch Arterial/efectos adversos , Operación de Switch Arterial/mortalidad , Estimulación Cardíaca Artificial , Niño , Preescolar , Supervivencia sin Enfermedad , Femenino , Defectos del Tabique Interventricular/diagnóstico por imagen , Defectos del Tabique Interventricular/mortalidad , Defectos del Tabique Interventricular/fisiopatología , Humanos , Lactante , Estimación de Kaplan-Meier , Masculino , Reoperación , Estudios Retrospectivos , Factores de Riesgo , Volumen Sistólico , Factores de Tiempo , Transposición de los Grandes Vasos/diagnóstico por imagen , Transposición de los Grandes Vasos/mortalidad , Transposición de los Grandes Vasos/fisiopatología , Resultado del Tratamiento , Función Ventricular Izquierda , Obstrucción del Flujo Ventricular Externo/etiología , Obstrucción del Flujo Ventricular Externo/fisiopatología , Obstrucción del Flujo Ventricular Externo/cirugía , Adulto Joven
13.
Kyobu Geka ; 70(7): 529-531, 2017 Jul.
Artículo en Japonés | MEDLINE | ID: mdl-28698422

RESUMEN

A 3-month-old female with ventricular septal defect underwent definitive repair. In the operation, a venting tube was inserted through the incised patent foramen ovale. The ventricular septal defect was closed using a patch and the incised patent foramen ovale was directly closed. A transesophageal echography showed no abnormal findings in the operating room. On 1st postoperative day, the patient's heart rate and pressure of the superior vena cava increased while blood pressure decreased. A transthoracic echocardiography revealed an atrial septal hematoma. After conservative therapy, the heart rate and pressure of the superior vena cava gradually decreased while blood pressure increased. The atrial septal hematoma disappeared spontaneously. The patient was discharged on 16th postoperative day. The atrial septal hematoma appears to have a good prognosis, but sometimes can be poor resulting and death. Meticulous and constant observation is required to detect an atrial septal hematoma.


Asunto(s)
Tabique Interatrial/diagnóstico por imagen , Defectos del Tabique Interventricular/cirugía , Hematoma/cirugía , Procedimientos Quirúrgicos Cardíacos/efectos adversos , Femenino , Hematoma/diagnóstico por imagen , Humanos , Lactante , Resultado del Tratamiento
14.
Echocardiography ; 34(8): 1203-1209, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28681451

RESUMEN

BACKGROUND: Aortic root dilatation (ARD) in congenital heart disease is related to aortic aneurysm, rupture, and dissection. This study aimed to investigate the factors associated with ARD in patients with surgically repaired ventricular septal defect (VSD). METHODS: This cross-sectional study included 152 patients with surgically repaired VSD. Two definitions of ARD were used: (1) observed Valsalva diameter to body surface area (BSA) ratio >2.1 cm/m2 and (2) absolute value of Valsalva diameter ≥4.0 cm. Odds ratios (ORs) and 95% confidence intervals (CIs) of ARD presence were calculated using multivariate logistic regressions. RESULTS: The prevalence of ARD ranged between 8.6% and 32.9%. Using the definition of observed aortic root diameter/BSA >2.1 cm/m2 , patients with nonsubarterial VSD type were more likely to have ARD (OR 5.65, 95% CI; 1.83-17.44, P=.003) than those with subarterial type, and patients with preoperative right- or noncoronary cusp prolapse (R/NCCP) were more likely to have ARD (OR 3.68, 95% CI; 1.20-11.23, P=.022) than patients without preoperative R/NCCP after adjustment for sex, age at repair (ie, shunt duration), VSD size, and postoperative follow-up period. Using the definition of absolute Valsalva diameter ≥4 cm, nonsubarterial VSD type and presence of R/NCCP were also significantly associated with ARD after adjustment for the same covariates. CONCLUSIONS: Anatomical and morphological features (nonsubarterial type and presence of preoperative R/NCCP) are independently correlated with ARD in patients with VSD regardless of the different definitions of ARD. Patients with surgically repaired VSD may need careful monitoring for potential ARD development.


Asunto(s)
Aneurisma de la Aorta/epidemiología , Procedimientos Quirúrgicos Cardíacos/efectos adversos , Defectos del Tabique Interventricular/cirugía , Medición de Riesgo , Seno Aórtico , Adulto , Aneurisma de la Aorta/diagnóstico , Aneurisma de la Aorta/etiología , Estudios Transversales , Ecocardiografía , Femenino , Estudios de Seguimiento , Defectos del Tabique Interventricular/diagnóstico , Humanos , Japón/epidemiología , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Prevalencia , Estudios Retrospectivos , Factores de Riesgo
15.
J Card Surg ; 32(7): 436-442, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-28573700

RESUMEN

BACKGROUND: The Fontan procedure is rarely performed in adults and adolescents in the present era. We review our results with the Fontan procedure in adolescents and young adults. METHODS: Between 1974 and 2010, 79 consecutive patients underwent the Fontan procedure at an age ≥ 15 years (mean age at Fontan operation, 20.3 years ± 4.5 years). Forty-five patients underwent atriopulmonary connection, 11 underwent the Bjork procedure, and 23 underwent total cavopulmonary connection. RESULTS: Ten hospital deaths (HDs) and/or early Fontan takedowns (TDs) occurred. The median follow-up period was 18.2 years (range, 0.6-37.6 years). The estimated freedom from death or TD rates was 79.7% at 5 years, 77.0% at 10 years, 73.9% at 15 years, and 63.9% at 20 years. Age was not a predictor of HD and/or TD. Freedom from death or TD after 1998 was 69.1% at 5 years, 69.1% at 10 years, and 69.1% at 15 years, and before 1997 was 82.3% at 5 years, 79.0% at 10 years, 75.5% at 15 years, and 65.1% at 20 years; there were no significant differences between the two groups. In 19 late-death patients, nine (47.4%) experienced sudden death. Among these patients, five had known arrhythmias before sudden death. CONCLUSIONS: In patients who were ≥15 years old, the surgical results of the Fontan operation were acceptable. Approximately half of the late deaths were sudden deaths, mainly occurring 10-20 years postoperatively.


Asunto(s)
Procedimiento de Fontan , Adolescente , Adulto , Factores de Edad , Muerte Súbita Cardíaca , Femenino , Estudios de Seguimiento , Procedimiento de Fontan/métodos , Procedimiento de Fontan/mortalidad , Humanos , Masculino , Periodo Posoperatorio , Pronóstico , Tasa de Supervivencia , Factores de Tiempo , Adulto Joven
16.
J Card Surg ; 31(11): 703-705, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-27611449

RESUMEN

The unilateral absence of a proximal pulmonary artery (UAPPA) is rare and is most frequently accompanied by cardiovascular anomalies such as tetralogy of Fallot or septal defects. We report a patient with truncus arteriosus with UAPPA in which we performed a two-stage surgical repair. During the first palliative operation, a right modified Blalock-Taussig shunt was constructed to develop the hypoplastic right pulmonary artery. At 10 months, the patient underwent patch closure of a ventricular septal defect with integration of both pulmonary arteries, and reconstruction of the right ventricular outflow tract using a conduit. Four years postoperatively, he continues to do well.


Asunto(s)
Anomalías Múltiples , Procedimientos Quirúrgicos Cardíacos/métodos , Ventrículos Cardíacos/cirugía , Arteria Pulmonar/anomalías , Tronco Arterial Persistente/cirugía , Malformaciones Vasculares/diagnóstico , Angiografía , Humanos , Recién Nacido , Masculino , Arteria Pulmonar/cirugía , Tronco Arterial Persistente/diagnóstico
17.
Asian Cardiovasc Thorac Ann ; 24(8): 765-771, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27563102

RESUMEN

BACKGROUND: This study aimed to evaluate Fontan circulation which was observed over 30 years. METHODS: Forty patients who underwent a Fontan operation between 1974 and 1986 and survived (group S, n = 20) or died in the late period (group LD, n = 20) were evaluated. The median age at operation was 10 years (range 2-32 years). The diagnoses were tricuspid atresia in 21, single ventricle in 9, and others in 10. The Fontan procedure was a right atrium-pulmonary artery graft in 2, atriopulmonary connection in 28, and right atrium-right ventricle anastomosis in 10 (Björk in 4, graft in 6). RESULTS: Causes of late death were congestive heart failure in 6, sudden death in 4, arrhythmia in 4, and others in 6. Sixteen patients underwent reoperation 23.3 ± 6.5 years after Fontan. Cardiac catheterization was performed at 1 month and 12 years. There were no significant differences in central venous pressure, ventricular ejection fraction, or pulmonary vascular resistance between the two groups. However, changes in ventricular end-diastolic volume suggested volume and pressure overload in group LD. In group S, the latest chest radiographs showed cardiothoracic ratio 51.3% ± 7.6%, oxygen saturation 94% ± 2%, brain natriuretic peptide 153 ± 111 pg c mL-1, and Holter monitoring revealed sinus rhythm in 10 patients. New York Heart Association class was I in 12 patients, II in 6, and III in 2. CONCLUSIONS: For long-term Fontan survival, timely total cavopulmonary connection conversion and medication to decrease ventricular volume and pressure load might be important.


Asunto(s)
Procedimiento de Fontan , Cardiopatías Congénitas/cirugía , Adolescente , Adulto , Fármacos Cardiovasculares/uso terapéutico , Causas de Muerte , Niño , Preescolar , Femenino , Procedimiento de Fontan/efectos adversos , Procedimiento de Fontan/mortalidad , Cardiopatías Congénitas/diagnóstico , Cardiopatías Congénitas/mortalidad , Cardiopatías Congénitas/fisiopatología , Hemodinámica , Humanos , Estimación de Kaplan-Meier , Masculino , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/mortalidad , Complicaciones Posoperatorias/cirugía , Reoperación , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Adulto Joven
18.
Ann Thorac Surg ; 102(4): 1353-9, 2016 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-27209612

RESUMEN

BACKGROUND: The arterial switch operation (ASO) for the transposition of the great arteries (TGA) with intramural coronary arteries has been performed using several techniques to avoid coronary events. We mainly performed ASO without coronary relocation by creating an aortopulmonary fenestration (Imai technique). Coronary circulation was rerouted by covering the aortopulmonary window and coronary orifices with a nonfacing sinus flap. Long-term results have not been reported. We describe our early and late results. METHODS: Among 551 patients who underwent an ASO between 1985 and 2014, intramural coronary arteries were detected in 15 of them. Coronary arteries were managed using 2 techniques: the double-button method in 5 patients (with unroofing and trapdoor incision in 1 patient) and the Imai technique in 10 patients. RESULTS: There were 3 hospital deaths and 3 deaths after discharge, 5 of which showed coronary complications. Actual survival and freedom from coronary complications at 15 years were 70% and 67%, respectively, with the Imai technique and 40% and 20%, respectively, with the double-button method. Late coronary intervention was performed for a long intramural coronary artery stenosis in 1 patient who underwent the Imai technique. In the others, late aortography showed good patency of the aortopulmonary window and growth of the coronary pouch after the Imai technique. CONCLUSIONS: The Imai technique can be an option for coronary management in the presence of high-risk coronary anatomy, particularly distal intramural coronary artery stenosis and inseparable coronary arteries with an almost single orifice. Adequate neopulmonary artery augmentation must be performed to prevent right ventricular outflow stenosis.


Asunto(s)
Operación de Switch Arterial/métodos , Vasos Coronarios/diagnóstico por imagen , Transposición de los Grandes Vasos/cirugía , Angiografía por Tomografía Computarizada , Angiografía Coronaria , Circulación Coronaria , Vasos Coronarios/fisiopatología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos , Transposición de los Grandes Vasos/diagnóstico , Resultado del Tratamiento
19.
Ann Thorac Surg ; 102(1): 186-91, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27083244

RESUMEN

BACKGROUND: Rastelli and réparation à l'étage ventriculaire (REV) procedures have been applied for biventricular repair of transposition of great arteries with ventricular septal defects and pulmonary stenosis (TGA III). In some patients with TGA III, whose tricuspid valve (TV) chordae tendineae are attached to the infundibular septum, abnormal TV chorda insertion may cause intracardiac rerouting obstruction. For such cases, we performed a conal flap" (CF) procedure involving mobilization of the infundibular septum including TV chordae as a pedicled flap. This study evaluated the long-term outcomes of this CF method. METHODS: Between October 1985 and December 1999, 17 consecutive patients with TGA III underwent a Rastelli-type or an REV-type procedure using CF. Median age at operation was 4.8 years (range, 1.5 to 14.0 years). RESULTS: The mean follow-up period was 17.8 ± 7.2 years. One hospital death and one late death occurred. The freedom from death rates were 94.1%, 94.1%, and 85.6% at 5, 10, and 15 years, respectively. The freedom from death or reoperation rates were 94.1%, 55.8%, and 46.5% at 5, 10, and 15 years, respectively. No reoperations were performed for the left ventricular outflow tract (LVOT) or TV. The average LVOT maximum flow velocity was 1.26 ± 0.50 m/s. TV regurgitation was greater than mild in 3 patients (20%) and trivial to mild in 12 patients (80%). Thirteen patients were in New York Heart Association (NYHA) functional class I, and 2 patients were in NYHA functional class II. CONCLUSIONS: The long-term outcomes, including the daily life activities, LVOT pressure gradients, and TV regurgitation grades, were excellent in patients who underwent Rastelli-type and REV-type procedures using CF for TGA III.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/métodos , Defectos del Tabique Interventricular/cirugía , Estenosis de la Válvula Pulmonar/cirugía , Colgajos Quirúrgicos , Transposición de los Grandes Vasos/cirugía , Insuficiencia de la Válvula Tricúspide/cirugía , Válvula Tricúspide/cirugía , Anomalías Múltiples , Adolescente , Niño , Preescolar , Ecocardiografía , Femenino , Estudios de Seguimiento , Defectos del Tabique Interventricular/diagnóstico , Humanos , Lactante , Masculino , Estenosis de la Válvula Pulmonar/diagnóstico , Estudios Retrospectivos , Factores de Tiempo , Transposición de los Grandes Vasos/diagnóstico , Resultado del Tratamiento , Válvula Tricúspide/diagnóstico por imagen , Insuficiencia de la Válvula Tricúspide/diagnóstico
20.
Interact Cardiovasc Thorac Surg ; 21(2): 151-6, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25924867

RESUMEN

OBJECTIVES: Whereas surgical outcomes of congenital heart surgery have improved during the past two decades, there are still measurable postoperative mortalities in this field. This study is aimed at evaluating the current situation of mortality following congenital heart surgery. METHODS: Data on all registered 28 810 patients in The Japan Congenital Cardiovascular Surgery Database (JCCVSD) between 2008 and 2012 were analysed, except for patients with degenerative cardiomyopathy including dilated, restrictive and hypertrophic cardiomyopathy, and pathologically or histologically malignant cardiac tumours. The number of registered cases increased every year, and reached ∼9000 cases in 2012. The median age at surgery was 0.8 years (range, 0-82). More than half of the patients (54%) who underwent surgery were <1 year old, and 6.0% of all patients were over 18 years old (adults). In this study, all mortalities within 90 days after the operation and mortality at discharge beyond 90 days of hospitalization were defined as '90-day and in-hospital mortality'. RESULTS: The 30-, 90-day and in-hospital mortality rates were 2.3, 3.5 and 4.5%, respectively. The mean and median durations from surgery to death were 61 ± 89 and 28 days (range, 0-717), respectively. Whereas 658 mortalities (51%) occurred within 30 days of surgery, 265 (21%) occurred later than 90 days after surgery. A total of 3630 patients (13%) were hospitalized for more than 90 days after the operation; of those, 3365 patients survived at discharge (93%). Cardiac problems were the most frequent causes of death after the surgery at any point in time, and 7.1 per 1000 patients died at over 30 days after the operation due to solely cardiac. CONCLUSIONS: The investigation of JCCVSD revealed that about a half of mortalities occurred later than 30 days; hence 90-day and in-hospital mortality would be a good discriminator that accurately represented the current situation of mortality after congenital heart surgery. Mortalities long after the operation due to post-cardiotomy heart failure without any other lethal complications were still not rare.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos/mortalidad , Cardiopatías Congénitas/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Bases de Datos Factuales , Femenino , Mortalidad Hospitalaria/tendencias , Humanos , Lactante , Recién Nacido , Japón/epidemiología , Masculino , Persona de Mediana Edad , Mortalidad/tendencias , Adulto Joven
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...