1.
Kidney360
; 5(2): 237-251, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38098136
2.
Eur J Med Chem
; 45(3): 1059-67, 2010 Mar.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20036447
RESUMEN
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.
Asunto(s)
Antioxidantes/farmacología , Antivirales/farmacología , Orthomyxoviridae/efectos de los fármacos , Silimarina/farmacología , Acilación , Animales , Línea Celular , Supervivencia Celular/efectos de los fármacos , Perros , Esterificación , Ácidos Grasos/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Silibina
3.