[Clinical efficacy of using ximedon in surgical practice]. / Klinicheskaia éffektivnost' primeneniia ksimedona v khirurgicheskoi praktike.

Results of clinical trial of the new pyrimidine derivative--ximedone are presented. The drug was administered per os 0.5 g x 4 times a day (0.5 h before meals). Total course dose achieved 60 g. Ximedone implementation for complex treatment of burns, trophic ulcer of lower limbs, different inflammations demonstrated positive results. Prophylaxy administration of the drug in abdominal surgery at acute appendix resulted with lower incidence of postoperative complications. High efficacy and good tolerability of the drug allows to recommend it for wide medical use.

[The use of xymedon in treating trophic ulcers of the lower extremities]. / Ispol'zovanie ksimedona v lechenii troficheskikh iazv nizhnikh konechnostei.

A new derivative of pyrimidine--Ximedon--was included in the complex treatment of 50 patients with trophic ulcers of lower extremities. The use of Ximedon resulted in shifts of homeostasis, of the cellular composition of the wound discharge, of metabolism of nucleic acids and activity of enzymes of the granulation tissue. Periods of the preoperative preparation of the patients became shorter. The immediate and long-term results obtained after such treatment were more stable.

[Dermatoplasty in the treatment of necrotic mastitis and breast erysipelas]. / Kozhno-plasticheskie operatsii pri lechenii nekroticheskikh form mastita i rozhistogo vospaleniia molochnoi zhelezy.

The authors had 15 female patients aged from 20 to 35 years with various diseases of the breast which were marked by necrosis of the skin and subcutaneous fat with involvement of 18 to 100% of the breast surface. The necrosis was caused by phlegmonous and infiltrative abscess producing forms of mastitis in 18 and by erysipelas in 7 cases. Necrotic mastitis and erysipelas developed in the first 2 weeks after delivery, as a rule, in patients with marked concomitant diseases of the heart and vessels. The patients were hospitalized 7 to 29 days after the onset of the disease. The development of severe forms of breast diseases was promoted by intensive manual abstraction of milk from the breast and retromammary antibiotic-novocaine blockades. After an operative intervention a complex of therapeutic measures was applied including semisynthetic antibiotics, agents containing protein globulin fractions, and dry and native blood plasma, and artificial polyuria with preceding hemodilution was produced. All patients underwent dermatoplasty with the use of a free split perforated skin graft. Lactorrhea in the region of the granulations was not a contraindication for surgical closure of the wound. Perforation of the skin graft was regarded a forced measure because the secretion of milk led to inevitable rejection of the transplant. The applied treatment produced quite satisfactory cosmetic and functional results.

[Ximedone in the treatment of patients with burns]. / Primenenie ksimedona v lechenii obozhzhennykh.

The authors studied xymedone, a new medicamentous agent from the group of pyrimidine derivatives. It was prescribed per os, 0.5 g taken three times daily. The experimental group consisted of 52 patients with IIIA and B degree thermal burns covering an area of 10 to 40%. The comparative appraisal was conducted with patients (60) treated by a complex of measures including methyluracil. Analysis of the obtained data showed a statistically significant, as compared to the controls, more rapid restoration of the peripheral blood parameters, decrease of C-reactive protein and level of sialic acid, and increase of total protein content and its gamma globulin fraction. Xymedone contributed to correction of blood dysproteinemia and produced an active effect on nucleic acid metabolism; the level of nucleic acids in the cells of the granulation tissue was much higher in the experimental group after treatment than in the controls. The normal ratio of T- and B-lymphocytes was restored and the phagocytosis indices grew. The production of coagulation and anticoagulation factors became normal, which coincided with cleaning of the granulations from fibrinous deposits and disappearance of the pathological predisposition to bleeding and easy damage of the granulation tissue. Under the effect of the agent the patients' appetite improved, the duration of the dehydration phase reduced, the rate of growth of microgranular granulations and epithelium increased, and the incidence of keloid cicatrices decreased. No unfavorable side effects of the agent were encountered. Xymedone is recommended for wide use in medical practice.

[Surgical strategy in acute thrombophlebitis of the superficial veins of the lower extremities]. / Taktika khirurga pri ostrom tromboflebite poverkhnostnykh ven nizhnikh konechnostei.

Active surgical policy in combined treatment of 98 patient with acute thrombophlebitis of the leg superficial veins provided good short- and long-term results in 73 of them. Urgent surgery was performed in cases with ascending thrombophlebitis of the large saphenous vein or thrombus location in the saphenofemoral anastomosis. No lethal outcome due to operative interventions were registered whereas conservative therapy resulted in 2 deaths from pulmonary artery thromboembolism.

[Fournier's gangrene]. / Gangrena Furn'e.

The authors describe 6 cases of Fournier gangrene. Early necrectomy and intensive conservative therapy should be used as the main method of treatment. Perfect recovery after extended defects of the skin was observed only following successful skin-plastic operations. Two patients died.