[MALLEOLAR ULCERS ASSOCIATED TO HYDROXYUREA TREATMENT]. / Úlceras maleolares asociadas al tratamiento con hidroxiurea.

INTRODUCTION: Hydroxyurea (HU) is an antineoplastic drug used in chronic myeloproliferative disorders. In this article we will go into detail about the rare but serious appearance of lower limb ulcers in relation to HU treatment. METHODOLOGY: Two simultaneous cases are presented, both from patients with lower limb torpid lesions unresponsive to conventional treatments. After dismissing other aetiologies, HU was found to be the causal agent in both cases. DISCUSSION: In spite of HU's known correlation to lower limb ulcers, pathogenesis isn't clearly defined. In this article we add two more cases to the existing bibliography, with the goal of both insisting on the importance of integral valuation of patients with ulcers and contemplating dermatologic screening on patients treated with HU. CONCLUSION: HU laden ulcers are usually underdiagnosed. Integral valuation and dermatologic screening on patients are critical.

Úlceras maleolares asociadas al tratamiento con hidroxiurea / Malleolar ulcers associated to hydroxyurea treatment

Introducción. La hidroxiurea (HU) es un reconocido agente antineoplásico utilizado desde hace años en síndromes mieloproliferativos crónicos. En este artículo ahondaremos en la poco frecuente pero grave aparición de úlceras en extremidades inferiores. Metodología. Presentamos dos casos simultáneos de pacientes con lesiones tórpidas en extremidades inferiores que no respondieron a tratamientos convencionales. Después de descartarse otras etiologías, se halló la HU como agente causal en ambos casos. Discusión. A pesar de que hace 30 años que se conoce la asociación entre HU y úlceras en extremidades inferiores, la patogénesis no está claramente definida. En este artículo añadimos dos casos más a la bibliografía ya existente, con el objetivo de insistir en la importancia de la valoración integral de los pacientes con úlceras y plantear un cribado dermatológico en pacientes en tratamiento con HU. Conclusión. Las úlceras secundarias a HU a menudo se infradiagnostican. Es importante la valoración integral y el cribado dermatológico en estos pacientes (AU)

Introduction. Hydroxyurea (HU) is an antineoplastic drug used in chronic myeloproliferative disorders. In this article we will go into detail about the rare but serious appearance of lower limb ulcers in relation to HU treatment. Methodology. Two simultaneous cases are presented, both from patients with lower limb torpid lesions unresponsive to conventional treatments. After dismissing other aetiologies, HU was found to be the causal agent in both cases. Discussion. In spite of HU’s known correlation to lower limb ulcers, pathogenesis isn’t clearly defined. In this article we add two more cases to the existing bibliography, with the goal of both insisting on the importance of integral valuation of patients with ulcers and contemplating dermatologic screening on patients treated with HU. Conclusion. HU laden ulcers are usually underdiagnosed. Integral valuation and dermatologic screening on patients are critical (AU)