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Alcohol Clin Exp Res ; 26(8): 1128-33, 2002 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-12198386

RESUMEN

BACKGROUND: Rats with streptozotocin (STZ)-induced diabetes exhibit alterations in cardiac function, ventricular remodeling, and changes in cell signaling, which includes protein kinase C (PKC) isoforms. Moderate consumption of ethanol has a beneficial effect on cardiovascular outcomes in the general population, an effect that has recently been found to extend to patients with diabetes mellitus. We studied the effect of low-dose ethanol consumption on cardiac function, geometry, and PKC isoforms in the rat with STZ-induced diabetes. METHODS: Four groups of rats were studied over 8 to 10 weeks: control, STZ-induced diabetes, 12% (v/v) ethanol consumption, and STZ-induced diabetes plus 4% (v/v) ethanol consumption. Invasive hemodynamic measurements were performed; myocardial tissue was obtained for analysis for total PKC and cytosolic and membrane protein content of PKC-alpha, PKC-delta, and PKC-epsilon, and two-dimensional and M-mode echocardiograms were obtained. RESULTS: Compared with rats with diabetes alone, consumption of 4% ethanol prevented the decrease in left ventricular dP/dt seen with diabetes alone, as well as the increase in left ventricular internal dimension. Up-regulation of PKC-alpha, -delta, and -epsilon occurring in the diabetic animals was also prevented by ethanol consumption, whereas ethanol alone had no effect on PKC isoform pattern. CONCLUSIONS: These data suggest that STZ-induced cardiac remodeling and dysfunction are associated with increases in PKC activity, particularly PKC-alpha, -delta, and -epsilon, and that consumption of ethanol can prevent these changes.


Asunto(s)
Cardiomiopatías/enzimología , Diabetes Mellitus Experimental/enzimología , Etanol/farmacología , Consumo de Bebidas Alcohólicas/metabolismo , Animales , Cardiomiopatías/inducido químicamente , Cardiomiopatías/fisiopatología , Diabetes Mellitus Experimental/fisiopatología , Modelos Animales de Enfermedad , Activación Enzimática/efectos de los fármacos , Etanol/sangre , Pruebas de Función Cardíaca , Hemodinámica/efectos de los fármacos , Isoenzimas/metabolismo , Masculino , Proteína Quinasa C/metabolismo , Ratas , Ratas Sprague-Dawley
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