1.
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI).
Bioorg Med Chem Lett
; 19(18): 5355-8, 2009 Sep 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19682901
RESUMEN
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet described. The structural model of 14a bound to E. coli FabI is shown.