1.
Exp Parasitol
; 135(2): 456-8, 2013 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23985373
RESUMEN
A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiplasmodial activities against a strain of chloroquine sensitive Plasmodium falciparum F32. Two compounds exhibited considerable effects against the malaria parasite (IC50 ≤ 1 µg/mL), one of which maintained the same level of activity in a chloroquine-resistant strain. This is the first record of antiplasmodial activity on this type of scaffold, providing a new structural motif as a new lead for antimalarial activity.