Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus.

The human papillomavirus (HPV) has an affinity for squamous cells of stratified keratinized epithelium, thus affecting the lower genital, nasal, and oral tracts. In the oral cavity, HPV is associated with pathoses such as the verruca vulgaris (common wart), squamous cell papilloma, condyloma acuminatum (venereal wart), and focal epithelial hyperplasia (Heck disease). Among the treatments available for these lesions are cryotherapy, electrosurgery, surgical removal, laser therapy, and trichloroacetic acid (TCA). The objective of this research was to determine the behavior of HPV-associated oral pathoses treated with TCA. A prospective cohort study was performed in 20 patients who attended a dental consultation at 2 universities in Cartagena, Colombia. Among the patients, 65% were diagnosed as having focal epithelial hyperplasia, 20% as having verrucae vulgares, and 15% as having condylomata acuminata. Application of TCA to HPV-associated oral lesions proved to be a useful nonsurgical alternative treatment, as the resolution of the lesions was achieved atraumatically in a span of 45 days with 3 applications of 30-60 seconds each.

Manifestaciones bucales de enfermedades de transmisión sexual identificadas en tres servicios de estomatología en Sur América / Oral manifestations of sexually transmitted diseases identified in three stomatology services in South America

Resumen Introducción: Las enfermedades de transmisión sexual se definen como un grupo de infecciones causadas por diversos agentes que se adquieren durante las relaciones sexuales. Éstas además suelen generar manifestaciones en boca. Objetivo: Determinar las lesiones características en cavidad bucal de enfermedades de transmisión sexual. Materiales y métodos: Estudio descriptivo transversal, con 37 pacientes que asistieron a los servicios de Estomatología de la Universidad de Buenos Aires, Universidad de Cartagena y el Hospital Alemán en Buenos Aires durante 2015 y 2016. Se realizó historia clínica completa con pruebas Venereal Disease Research Laboratory (VDRL) y Fluorescent Treponemal Antibody Absortion (FTA-ABS) en pacientes con presunción de sífilis. Además de análisis histopatológico y Reacción en Cadena de la Polimerasa (PCR) en pacientes con presunción de Virus de Papiloma Humano (VPH). Resultados: El promedio de edad de los pacientes fue de 38 años, predominó el sexo masculino. El 54,1% fueron diagnosticados con sífilis y la lesión más encontrada en estos fue la pápula. El 45,9% restante fueron diagnosticados con VPH, la lesión predominante en estos fue la verrugosidad. Conclusiones: El odontólogo debe contribuir en la detección temprana de enfermedades de transmisión sexual identificando manifestaciones de éstas en boca; con el fin de evitar su evolución y prevenir su transmisión.

Abstract Introduction: Sexually transmitted diseases are defined as a group of infections caused by various agents which are acquired during sexual intercourse. They also tend to generate manifestations in the mouth. Objective: To determine the typical lesions in oral cavity of sexually transmitted diseases. Materials and methods: A descriptive transversal study was conducted with 37 patients who attended the stomatology services of the University of Buenos Aires, University of Cartagena and the Aleman Hospital in Buenos Aires during 2015 and 2016. A complete clinical history was carried out with Venereal Disease Research Laboratory (VDRL) and Fluorescent Treponemal Antibody Absortion (FTA-ABS) tests in patients with presumption of syphilis. In addition, histopathological analysis and Polymerase Chain Reaction (PCR) was made in patients with presumption of Human papillomavirus (HPV). Results: The average age of the patients was 38, where male sex predominated. 54.1% were diagnosed with syphilis and the most found lesion in them was the papule. The remaining 45.9% were diagnosed with HPV, the predominant lesion in them was a wart. Conclusions: The dentist should contribute to the early detection of sexually transmitted diseases by identifying manifestations of these in the mouth in order to prevent their evolution and prevent their transmission.