RESUMEN
A case of tophaceous gout of the navicular bone in a 24-year-old woman is reported. Emphasis is placed on the conditions that might have been precipitating, i.e., anorexia nervosa and alcoholism, and the mechanisms by which increased uric acid level may be explained. The main radiographic patterns of tophaceous gout of the foot are recalled to avoid unnecessary surgery in future cases.
Asunto(s)
Enfermedades del Pie/etiología , Gota/complicaciones , Gota/patología , Inflamación/etiología , Huesos Tarsianos/patología , Adulto , Alcoholismo/complicaciones , Anorexia Nerviosa/complicaciones , Anorexia Nerviosa/metabolismo , Cristalización , Femenino , Enfermedades del Pie/diagnóstico , Enfermedades del Pie/patología , Gota/diagnóstico , Gota/etiología , Granuloma de Cuerpo Extraño , Humanos , Ácido ÚricoRESUMEN
We report a case of congenital cervical rhabdoid tumor with association of a medulloblastoma in a brother. The immunohistochemical features of this tumor are compatible with a neuroectodermal differentiation (MIC 2+, Leu 7+). Extrarenal rhabdoid tumors share a common morphology but do not represent a single entity with only one histogenesis. Most of them are now considered to be of neuroectodermal origin. In our case, the association with a medulloblastoma in a brother seems to confirm this concept.
Asunto(s)
Meduloblastoma/patología , Tumor Rabdoide/patología , Neoplasias de los Tejidos Blandos/patología , Diferenciación Celular/fisiología , Humanos , Recién Nacido , Masculino , Meduloblastoma/genética , Cuello , Fenotipo , Tumor Rabdoide/congénito , Tumor Rabdoide/genética , Neoplasias de los Tejidos Blandos/congénito , Neoplasias de los Tejidos Blandos/genéticaRESUMEN
Two cases of cardiac rhabdomyoma have recently been observed in foetuses. The cardiac and muscular nature of the cells was confirmed by immunohistochemistry using monoclonal antibodies. A review of the literature shows that cardiac rhabdomyomas are usually considered to be hamartomas which are composed of primitive myocardial cells. Their spontaneous regression is often observed and apoptosis has been proposed as a possible mechanism of such a phenomenon. We propose that cardiac rhabdomyomas should be better considered as developmental vestiges rather than as true hamartomas. These vestigial structures would result either from a defect in differentiation, or from a defect in regression of primitive myocardial cells.