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Epidemiol Infect ; 140(3): 447-53, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-21524344

RESUMEN

A rubella outbreak involving 1900 cases was recorded in the Federation of Bosnia and Herzegovina between mid-December 2009 and the end of May 2010. Sera from 389 suspected rubella cases were examined for the presence of rubella-specific IgM and IgG antibodies. A total of 32 throat swabs from suspected rubella cases were tested by RT-PCR and were used to attempt virus isolation. Most patients (945/1900, 49·73%) had never received rubella vaccination or had an unknown vaccination status (563/1900, 29·63%). About 45% (178/389) of suspected rubella patients were IgM positive. From 13 of the throat swabs a virus isolate and E1 gene sequences attributed to genotype 2B were obtained. The rubella outbreak was due to failure to vaccinate during the war period (1992-1995) and emphasizes the need for additional vaccination opportunities.


Asunto(s)
Brotes de Enfermedades , Vacuna contra la Rubéola/administración & dosificación , Vacuna contra la Rubéola/inmunología , Rubéola (Sarampión Alemán)/epidemiología , Vacunación/estadística & datos numéricos , Adolescente , Adulto , Anticuerpos Antivirales/sangre , Bosnia y Herzegovina/epidemiología , Niño , Preescolar , Femenino , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Lactante , Masculino , Faringe/virología , Embarazo , ARN Viral/genética , ARN Viral/aislamiento & purificación , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Virus de la Rubéola/genética , Virus de la Rubéola/aislamiento & purificación , Guerra , Adulto Joven
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