Internet-delivered cognitive behavioral therapy for anxiety among university students: A systematic review and meta-analysis.

University years are marked by multiple stressors. Consequently, university students often report anxiety symptoms or disorders, but most remain untreated. Internet-delivered cognitive behavioral therapy (ICBT) has been proposed as an alternative to address known help-seeking barriers, which were aggravated during the COVID-19 pandemic. This meta-analysis aims to evaluate the efficacy of ICBT for university students with anxiety. A systematic search on three databases, EBSCOhost, PubMed, and Web of Science, and a manual search were performed. Fifteen studies were identified, including a total of 1619 participants. Seven studies evaluated ICBT treatment for both anxiety and depression, three for social anxiety, two for generalized anxiety, while the remaining (k = 3) only targeted anxiety, test anxiety, and comorbidity between anxiety and insomnia. Analyses were performed based on a random-effects model using the metafor package in R. The results indicated that ICBT had a significant and positive effect on university students with anxiety compared to controls at post-test (g = -0.48; 95 % CI: -0.63, -0.27; p < .001, I 2  = 67.30 %). Nevertheless, more research is required to determine the intervention components that are more relevant for therapeutic change, how much guidance is required to produce better outcomes, and how patient engagement can be improved.

Emotional Dysregulation Mediates the Association Between Unsupportive Maternal Socialization Strategies of Overjoy and Psychopathological Symptoms in Adolescent Boys but not Girls.

Mothers play an important role in the emotion socialization of their teenage children, with implications for psychological adjustment. However, studies on maternal socialization of positive emotions in adolescence are still scarce and inconclusive. In this study, we aim to deepen our understanding on the association between unsupportive maternal socialization strategies of overjoy and internalization but also externalization symptoms as mediated by emotion dysregulation, and moderated by adolescents' gender. The study was conducted with 418 adolescents (M age = 14.75; 57.7% girls). Moderated mediation analysis indicated the effect of punishment and override of overjoy on internalization (punishment: b = 1.38, 95% CI [0.63, 2.31]; override: b = 1.36, 95% CI [0.59, 2.31]) and externalization (punishment: b = 0.71, 95% CI [0.20, 1.34]; override: b = 0.77, 95% CI [0.26, 1.46]) was mediated by emotional dysregulation in the case of boys. Contrary to expectations, for girls this effect was not found, indicating that further analysis are required.

New version of the emotion socialization scale with the positive emotion of overjoy: initial validation evidence with Portuguese adolescents.

There are few studies on parental socialization of positive emotions in adolescents and few instruments that measure these parental reactions. Therefore, we developed a new version of the Emotion Socialization Scale (ESS) for the positive emotion of overjoy. We further provided some evidence of validity and reliability of the Portuguese ESS, featuring overjoy, fear, anger, and sadness. Adolescents (N = 418) answered questionnaires on maternal emotion socialization and maternal rearing practices. Confirmatory factor analysis achieved good (reward, neglect, override, magnify) to acceptable (punish) levels of fit, and scales had good levels of internal consistency, except for punish (all emotions) and neglect (overjoy). Association with maternal rearing practices supported the adaptive role of reward and magnify and the less adaptive role of punish, override, neglect of positive emotion, with some exceptions. This investigation demonstrated the importance of assessing parents' reactions to adolescents' positive emotion as these may be important indicators of the parent-adolescent relationship quality.

New version of the emotion socialization scale with the positive emotion of overjoy: initial validation evidence with Portuguese adolescents

Abstract There are few studies on parental socialization of positive emotions in adolescents and few instruments that measure these parental reactions. Therefore, we developed a new version of the Emotion Socialization Scale (ESS) for the positive emotion of overjoy. We further provided some evidence of validity and reliability of the Portuguese ESS, featuring overjoy, fear, anger, and sadness. Adolescents (N = 418) answered questionnaires on maternal emotion socialization and maternal rearing practices. Confirmatory factor analysis achieved good (reward, neglect, override, magnify) to acceptable (punish) levels of fit, and scales had good levels of internal consistency, except for punish (all emotions) and neglect (overjoy). Association with maternal rearing practices supported the adaptive role of reward and magnify and the less adaptive role of punish, override, neglect of positive emotion, with some exceptions. This investigation demonstrated the importance of assessing parents' reactions to adolescents' positive emotion as these may be important indicators of the parent-adolescent relationship quality.

Peptide selection and antibody generation for the prospective immunorecognition of Cry1Ab16 protein of transgenic maize.

The introduction of genes isolated from different Bacillus thuringiensis strains to express Cry-type toxins in transgenic crops is a common strategy to confer insect resistance traits. This work intended to extensively in silico analyse Cry1A(b)16 protein for the identification of peptide markers for the biorecognition of transgenic crops. By combining two different strategies based on several bioinformatic tools for linear epitope prediction, a set of seven peptides was successfully selected as potential Cry1A(b)16 immunogens. For the prediction of conformational epitopes, Cry1A(b)16 models were built on the basis of three independent templates of homologue proteins of Cry1A(a) and Cry1A(c) using an integrated approach. PcH_736-746 and PcH_876-886 peptides were selected as the best candidates, being synthesised and used for the production of polyclonal antibodies. To the best of our knowledge, this is the first attempt of selecting and defining linear peptides as immunogenic markers of Cry1A(b)-type toxins in transgenic maize.

Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora.

Pilocarpus microphyllus Stapf ex Wardleworth (jaborandi, Rutaceae) is one of the most important Brazilian medicinal species owing to its content of pilocarpine (PIL), an alkaloid used for treating glaucoma and xerostomia. This species contains another alkaloid, epiisopiloturine (EPI), which has demonstrated effectiveness against schistosomiasis. The aim of this work was to assess seasonal changes of PIL and EPI in three populations of cultivated P. microphyllus from northeastern Brazil over one year, including the dry and rainy seasons. Alkaloid profiles were correlated to phenotypic and genetic patterns in the morphological and molecular characterizations. PIL was the primary alkaloid and its levels differed among populations in all months except September. The S01 population (green line) showed an especially high PIL content compared to populations S02 and S03 (traditional line), which had similar alkaloid contents. PIL content gradually decreased in the three populations in the rainy season.EPI content was significantly different between the green line (S01) and the traditional line (S02 and S03).S01 had a significantly lower EPI content in all months, demonstrating that it was not the best source for EPI extraction. Inter simple sequence repeat (ISSR) markers and morphological analyses clearly separated S01 from S02 and S03, in agreement with the alkaloid results. This study shows the first correlation between the chemical, morphological, and molecular markers of P. microphyllus and highlights the potential benefits of a multidisciplinary research approach aimed at supporting both industry and conservation of natural resources.