RESUMEN
The aqueous extract of Rhizophora mangle bark and its polyphenolic fractions showed remarkable in vitro antiinflammatory activity in a preliminary study. The low molecular weight fraction exhibited cyclooxygenase-2 inhibitory activity while the total aqueous extract and the low molecular weight fraction showed secretory phospholipase A(2) inhibitory activity.
Asunto(s)
Ciclooxigenasa 2/efectos de los fármacos , Proteínas de la Membrana/efectos de los fármacos , Fosfolipasas A/efectos de los fármacos , Fitoterapia , Extractos Vegetales/farmacología , Rhizophoraceae , Inhibidores de la Ciclooxigenasa 2/administración & dosificación , Inhibidores de la Ciclooxigenasa 2/farmacología , Inhibidores de la Ciclooxigenasa 2/uso terapéutico , Relación Dosis-Respuesta a Droga , Inhibidores Enzimáticos/administración & dosificación , Inhibidores Enzimáticos/farmacología , Inhibidores Enzimáticos/uso terapéutico , Flavonoides/administración & dosificación , Flavonoides/farmacología , Flavonoides/uso terapéutico , Humanos , Proteínas de la Membrana/antagonistas & inhibidores , Fenoles/administración & dosificación , Fenoles/farmacología , Fenoles/uso terapéutico , Fosfolipasas A/antagonistas & inhibidores , Corteza de la Planta , Extractos Vegetales/administración & dosificación , Extractos Vegetales/uso terapéutico , PolifenolesRESUMEN
The antioxidant activity of Rhizophora mangle bark aqueous extract and its majoritary component and high molecular weight polyphenols' fraction were studied using deoxyribose assay. The total extract and its fraction showed scavenging activity of hydroxyl radicals and hability to chelate iron ions.
Asunto(s)
Antioxidantes/farmacología , Flavonoides/química , Quelantes del Hierro/farmacología , Fenoles/química , Extractos Vegetales/farmacología , Rhizophoraceae/química , Antioxidantes/química , Antioxidantes/aislamiento & purificación , Radical Hidroxilo/química , Hierro/química , Quelantes del Hierro/química , Quelantes del Hierro/aislamiento & purificación , Corteza de la Planta/química , Extractos Vegetales/química , Polifenoles , Agua/químicaRESUMEN
The nematophagous fungus, Pochonia chlamydosporia var. catenulata (Kamyschlco ex Barron & Onions) Zare & W-Gams, was investigated as a potential biocontrol agent in integrated pest management strategy for Meloidogyne incognita (Kofoid and White) Chitwood in vegetable crops in Cuba. An acute oral and dermal toxicity/patogenicity study was performed to determine the safety of this fungus in non-target organisms. In the first study, a 1-dose level of 5 x 10(8) units of the microbial pest control agent/treated rat was used. Mortality or clinical signs were not evident and no adverse effects on body weight, hematology, microbiology and gross or microscopic pathology were observed. Food and water consumption was not significantly different between control and treated groups. In the acute dermal toxicity study, there was neither mortality nor clinical signs of toxicity, and no toxic effects in gross and microscopic pathology were detected. Thus, Pochonia chlamydosporia var. catenulate (Vcc-108, IMI SD 187), administered oral and dermally to rats and rabbits respectively, was safe in toxicity/pathogenicity studies.