RESUMEN
Morphea, a localized form of scleroderma, is a chronic inflammatory autoimmune disease of the skin. Color Doppler Ultrasound has been reported as a reliable tool to assess the activity of the disease. With histologically confirmed cases, this case series describes a new ultrasound sign consisting of a hyperechoic halo surrounding superficial subcutaneous veins of the extremities in transverse view, named the sun sign. This sign can help diagnose morphea in the inflammatory phase and correlate in pathology with perivascular infiltrates surrounding superficial subcutaneous veins.
Asunto(s)
Esclerodermia Localizada , Enfermedad Crónica , Humanos , Esclerodermia Localizada/diagnóstico por imagen , Esclerodermia Localizada/patología , Piel/diagnóstico por imagen , Ultrasonografía , Ultrasonografía Doppler en ColorRESUMEN
Seven new steroids, compounds 1-7, were isolated from the Antarctic octocoral Anthomastus bathyproctus. The structures of the new metabolites have been established by analysis of their spectroscopic data. The in vitro cytotoxicity has been tested against three human tumor cell lines.
Asunto(s)
Antozoos/química , Antineoplásicos/aislamiento & purificación , Esteroides/aislamiento & purificación , Animales , Regiones Antárticas , Antineoplásicos/química , Antineoplásicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Esteroides/química , Esteroides/farmacología , Células Tumorales CultivadasRESUMEN
The chemical study of the Antarctic octocoral Dasystenella acanthina has led to the isolation of the new polyoxygenated steroids (24R,22E)-24-hydroxycholest-4,22-dien-3-one (1), 23-acetoxy-24,25-epoxycholest-4-en-3-one (2), 12beta-acetoxycholest-4-en-3,24-dione (3), 12beta-acetoxy-24,25-epoxycholest-4-en-3-one (4), (22E)-25-hydroxy-24-norcholest-4,22-dien-3-one (5), 3alpha-acetoxy-25-hydroxycholest-4-en-6-one (6), and 3alpha,11alpha-diacetoxy-25-hydroxycholest-4-en-6-one (7), whose structures have been established by spectroscopic analysis. The absolute stereochemistry at C-24 in compound 1 has been determined through the 1H NMR study of the corresponding (R)- and (S)-MPA esters. All the new compounds showed significant activities as growth inhibitors of several human tumor cell lines. In addition, cytostatic and cytotoxic effects were also observed on selected tumor cell lines.