Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
1.
Am J Rhinol Allergy ; 23(2): 177-80, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19401045

RESUMEN

BACKGROUND: The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients. METHODS: We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed. RESULTS: Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis. CONCLUSION: The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability.


Asunto(s)
Lepra/diagnóstico , Lepra/fisiopatología , Mycobacterium leprae , Mucosa Nasal/patología , Piel/patología , Adolescente , Anciano , Anciano de 80 o más Años , Biopsia , Niño , Progresión de la Enfermedad , Diagnóstico Precoz , Humanos , Lepra/patología , Persona de Mediana Edad , Mucosa Nasal/microbiología , Valor Predictivo de las Pruebas , Índice de Severidad de la Enfermedad , Piel/microbiología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA