Efficacy and limitations of different approaches to anticipate the diagnosis of pregnancy in cattle / Eficácia e limitações de diferentes abordagens para antecipar o diagnóstico de gestação em bovinos

The study evaluated sonographic and serologic exams performed for early (20 to 30d) diagnosis of pregnancy. One hundred-twenty (n= 120) bovine recipients were synchronized (estrous=D0) and timed embryo transferred (TET, D7) with fresh in vitro produced embryos. In the first trial (n= 46), diagnosis of pregnancy was performed on day 20 (D20) by detecting CL blood flow (BF) and by Pregnancy-Associated Glycoproteins (PAGs) serology. In the second trial (n= 30), pregnancy diagnosis was performed on D25 by ultrasound visualization of uterine contents and by PAGs serology. In the last trial, PAG's serology was performed on D30. Ultrasonographic detection of the uterine contents and embryo viability performed on D30 (DG30) was considered the gold standard. The PROC FREQ procedure was used to test the agreement between diagnostic methods. On D20, the Doppler ultrasonography of the CL had showed high sensitivity (100%), but only moderate specificity (53.3%). On the same day, serologic diagnostic had no agreement (k= -0.08, P< 0.46) with the gold standard, with very low sensitivity (6.3%). However, the sensitivity of the serologic exam increased dramatically (from 6.3 to 100%) from D20 to D25, and it contributed to detect false negatives from the ultrasound diagnosis, improving the overall accuracy from 90% to 96.7%.(AU)

O estudo foi planejado para correlacionar exames ultrassonográficos e sorológicos realizados para o diagnóstico precoce (20 a 30d) de gestação. Cento e vinte (n= 120) receptoras bovinas foram sincronizadas (estro=D0), e embriões frescos produzidos in vitro foram transferidos em tempo fixo (TETF, D7). No experimento 1 (n= 46), o diagnóstico de gestação foi realizado no D20, pela detecção do fluxo sanguíneo do CL e pela sorologia de glicoproteínas associadas à gestação (PAGs). No experimento 2 (n= 30), a detecção da gestação foi realizada por meio da visualização do conteúdo do útero e também pela sorologia para PAGs. No experimento 3, a sorologia para PAGs foi realizada no D30. Em todos os experimentos, a visualização ultrassonográfica da vesícula e da viabilidade embrionária, realizada no D30, foi considerada padrão-ouro. O procedimento PROC FREQ testou o nível de concordância dos métodos diagnósticos. No D20, o diagnóstico baseado na vascularização do CL mostrou alta sensibilidade (100%) e apenas moderada especificidade (53,3%). Nesse mesmo dia, o diagnóstico sorológico não apresentou concordância (k=-0,08, P<0,46) com o padrão-ouro, além de baixa sensibilidade (6,3%). No entanto, a sensibilidade do exame sorológico aumentou drasticamente (6,3 para 100%) do D20 para o D25, contribuindo para detectar falsos negativos diagnosticados pela ultrassonografia, melhorando a acurácia (90 para 96,7%).(AU)

Treatments for intrusive luxation in permanent teeth: a systematic review and meta-analysis.

Intrusive luxation is a severe form of dental trauma and there is no consensus regarding its management for permanent teeth. A systematic review and meta-analysis was performed to identify the appropriate treatment for teeth with intrusive luxation. The PubMed/MEDLINE, Embase, US Clinical Trials, and ISRCTN Registry electronic databases were used to search for articles in English and unpublished studies without a date limit. Eligible studies evaluated periodontal results (root resorption as the primary outcome; marginal bone defects and/or pulpal changes as secondary outcomes) after spontaneous re-eruption (SRE), orthodontic repositioning (ORP), or surgical repositioning (SRP) for patients with one or more traumatically intruded permanent teeth. Risk ratios with 95% confidence intervals were used to compare treatments. The meta-analysis revealed no significant difference (P>0.05) between SRP and SRE for root resorption. For secondary outcomes, SRE was significantly better than SRP and ORP (P<0.05). Subgroup analyses showed no significant differences among treatments in teeth with completely formed roots (P>0.05) and a better prognosis when SRE was performed in teeth with incompletely formed roots (P<0.05). The available evidence does not allow us to conclude on the best treatment for traumatically intruded teeth. More reliable evidence is needed.

Maxillary sinus lift surgery-with or without graft material? A systematic review.

The purpose of this systematic review was to perform a comparative analysis of the use or not of graft material in maxillary sinus lift surgery. Relevant studies published in the last 10 years were identified through a search of the PubMed/MEDLINE, ScienceDirect, and Cochrane Library databases and were assessed against the study inclusion and exclusion criteria. The initial search resulted in 1037 articles. After applying the inclusion and exclusion criteria, 16 articles remained. Four hundred and thirty-six patients were followed up over a postoperative period ranging from 6 months to 11 years. In total, 868 implants were installed in 397 maxillary sinuses. The implant survival rate was 96.00% for surgeries performed without graft material and 99.60% for those in which biomaterial was used, within a follow-up period of 48 to 60 months. In conclusion, maxillary sinus lift surgery, with or without graft material, is a safe procedure with a low complication rate and predictable results.

Labiolingual and mesiodistal positioning of maxillary permanent incisors during the eruption process.

This study aimed to establish radiographical parameters concerning the tipping, the labiolingual positioning and the angulation of the maxillary permanent incisors in the mixed dentition. Three groups of 20 cephalograms and 20 orthopantomographic radiographs taken from children aging from 7 to 12 years old, with normal occlusion were compared. The Group I presented only the eruption of the central permanent incisors, the Group II presented both the central and lateral permanent incisors and the Group III presented central, lateral incisors and permanent canine teeth. The tipping and the labiolingual positioning were measured, respectively, using U1/PP and U1<-->AVERT. Mesiodistally, the angles between the teeth axis and the line that touched the lower border of the orbit in the orthopantomographic radiographs were measured. The mean values of tipping, labiolingual positioning and angulation of the central and lateral incisors obtained from Groups I, II and III were respectively 112 degrees, 1.2 mm, 90.4 degrees and 91.7 degrees; 112 degrees, 2.6 mm, 89.5 degrees and 96.8 degrees and 114 degrees, 2.7 mm, 87.4 degrees and 92.6 degrees. The tipping levels were similar for all groups, the mean values of the labiolingual positioning were significantly different at 5% when Group I was compared to both Groups II and III. And the mean values of the angulation were significantly different 5% for the central incisors between Groups I and III, and at 1% for the lateral incisors between Groups I and II, and, II and III.

Loss of space and dental arch length after the loss of the lower first primary molar: a longitudinal study.

The premature loss of primary teeth may harm the normal occlusal development, although there are debates relating to the necessity of using space maintainer appliances. The aim of the study is to evaluate the changes in the dental arch perimeter and the space reduction after the premature loss of the lower first primary molar in the mixed dentition stage. The sample consists of 4 lower arch plaster models of 31 patients, within the period of pre-extraction, 6, 12 and 18 months after the lower first primary molar extraction. A reduction of space was of noted with the cuspid dislocation and the permanent incisors moving toward the space of the extraction site. It was concluded that the lower first molar primary premature loss, during the mixed dentition, implicates an immediate placement of a space maintainer.