RESUMEN
Purpose: Despite newer type 2 diabetes (T2D) medications, patients do not always achieve metabolic targets, remaining at risk for cardiorenal complications. Therapeutic decisions are generally made by the healthcare team without considering patients' preferences. We aimed to evaluate patients' T2D treatment preference in two Latin-American countries between two different oral medication profiles, one resembling dipeptidyl peptidase-4 inhibitors (DPP4i) and another resembling sodium-glucose cotransporter-2 inhibitors (SGLT2i). Patients and Methods: In this cross-sectional, multicenter study from June to September 2020, patients with T2D from Argentina and Mexico (n = 390) completed a discrete choice experiment questionnaire to identify preferences between DPP4i (medication profile A) and SGLT2i (medication profile B). The reason behind patients' choice, and the association between their baseline characteristics and their preference were evaluated using logistic regression methods. Results: Most participants (88.2%) preferred SGLT2i's profile. Participants with older age (p = 0.0346), overweight or obesity (p < 0.0001), high blood pressure (BP; p < 0.0001), high total cholesterol (p = 0.0360), and glycosylated hemoglobin (HbA1c) <7% (p = 0.0001) were more likely to choose SGLT2i compared with DPP4i's profile. The most and least important reasons to choose either drug profile were HbA1c reduction and genital infection risk, respectively. The likelihood of selecting the SGLT2i's profile significantly increased in participants with increased body mass index (BMI; odds ratio [OR] = 8.9, 95% confidence interval [CI]: 3.5-22.5, p < 0.05), high BP (OR = 4.9, 95% CI: 1.9-12.4, p < 0.05), and lower education level (OR = 3.6, 95% CI: 1.0-12.6, p < 0.05). Conclusion: Latin-American patients with T2D preferred medication with a profile resembling SGLT2i over one resembling DPP4i as a treatment option. A patient-centered approach may aid the healthcare team in decision-making for improved outcomes.
RESUMEN
Background: Type 2 diabetes mellitus (DM2) represents one of the ten non- transmissible chronic diseases that constitute the main causes of death and disability in Mexico. It is the leading cause of disability and the second cause of death. The IMSS serves 4.2 million people living with this disease. Objective: Establish lines of action that allow standardizing the substantive activities to be carried out by the multidisciplinary health team, promoting healthy lifestyles, establishing timely diagnoses, providing adequate and intensified care and treatments, preventing complications, and providing comprehensive care and of quality for the benefit of the beneficiaries. Material and methods: The process of development of the Integrated Care Protocols consisted of: 1) Prioritization of the health problem, 2) Conformation of an interdisciplinary work group, 3) Development of content and systematic search for information 4) Analysis, review and discussion of interventions, 5) Review and validation by regulatory areas, 6) Dissemination and implementation. Conclusions: Promotion and prevention actions must be carried out at all levels and by all health personnel, likewise, the incorporation of new treatments for DM2 in the IMSS, requires the homologation of the criteria in risk stratification, diagnosis, profile risk of hypoglycemia and adverse effects to limit the complications of the disease and reduce the burden of disease (disability and premature death).
Introducción: la diabetes mellitus tipo 2 (DM2) es una de las diez enfermedades crónicas no transmisibles que constituyen las principales causas de muerte y discapacidad en México, es la principal causa de invalidez y la segunda de muerte. El Instituto Mexicano del Seguro Social (IMSS) atiende a 4.2 millones personas que viven con esta enfermedad. Objetivo: establecer líneas de acción que permitan homologar las actividades sustantivas que debe llevar a cabo el equipo multidisciplinario de salud, promoviendo estilos de vida saludables, estableciendo diagnósticos oportunos, otorgando atención y tratamientos adecuados e intensificados, previniendo complicaciones y brindando atención integral y de calidad para el beneficio de los derechohabientes. Material y métodos: el proceso de desarrollo de los Protocolos de Atención Integral consistió en: 1) Priorización del problema de salud; 2) Conformación de grupo de trabajo interdisciplinario; 3) Desarrollo del contenido y búsqueda sistemática de información; 4) Análisis, revisión y discusión de las intervenciones; 5) Revisión y validación por las áreas normativas, y 6) Difusión e implementación. Conclusiones: las acciones de promoción y prevención deben realizarse en todos los niveles y por parte de todo el personal de salud; asimismo, la incorporación de nuevos tratamientos para DM2 en el IMSS requiere de la homologación de los criterios en estratificación de riesgo, diagnóstico, perfil riesgo de hipoglucemia y efectos adversos, con el objetivo de limitar las complicaciones de la enfermedad y disminuir la carga de enfermedad (discapacidad y muerte prematura).
