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1.
Pediatr Nephrol ; 32(12): 2311-2318, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28667458

RESUMEN

BACKGROUND: Variability in measures of mineral metabolism has not been studied in pediatric end stage kidney disease. We sought to determine the intra-individual variability in measures of mineral metabolism in children on hemodialysis (HD) and its impact on clinical decision-making. METHODS: We conducted a prospective single-center study of children (3.6-17.3 years old) on chronic HD. Serial twice weekly measures of serum calcium, phosphate and intact parathyroid hormone (PTH), as well as weekly measures of fibroblast growth factor 23 (FGF23) and vitamin D metabolites, were obtained over a 12-week period in 10 children. Samples (n = 226) were assayed in a single batch at the end of the study. RESULTS: The median intra-individual coefficient of variation (CV) calculated by 4-week blocks was 5.1-6.5% for calcium, 9.5-14.9% for phosphate and 32.7-33.4% for PTH. The median overall CV for FGF23 was 44.4%. Using the first value of each block as a reference, subsequent values would dictate a discrepant management decision 33-56%, 19-28%, and 30-33% of the time for calcium, phosphate, and PTH, respectively. Adjusting for sex and age, most of the variability in phosphate and PTH was attributable to within-participant variability. For calcium, 49% of the variability was attributable to day of blood collection (Monday vs. Friday). The median (range) of an individual participant's values within clinical target ranges was 55% (26-86%) for calcium, 58% (0-96%) for phosphate, and 21% (0-64%) for PTH. CONCLUSIONS: There is considerable intra-individual variability in measures of mineral metabolism that serve as surrogate markers for bone health in children on HD. Within a 4-week period, at least 20-30% of measures would dictate a discrepant decision from the referent measure of that month. These findings have important implications for clinical decision-making and underscore the need to base therapeutic decisions on trends rather than single measurements.


Asunto(s)
Variación Biológica Poblacional , Toma de Decisiones Clínicas/métodos , Fallo Renal Crónico/sangre , Minerales/metabolismo , Diálisis Renal/efectos adversos , Adolescente , Biomarcadores/sangre , Huesos/metabolismo , Calcio/sangre , Niño , Preescolar , Femenino , Factor-23 de Crecimiento de Fibroblastos , Factores de Crecimiento de Fibroblastos/sangre , Humanos , Fallo Renal Crónico/terapia , Estudios Longitudinales , Masculino , Minerales/sangre , Hormona Paratiroidea/sangre , Fosfatos/sangre , Estudios Prospectivos , Diálisis Renal/métodos , Vitamina D/sangre , Vitamina D/metabolismo
2.
Pediatr Nurs ; 42(2): 89-92, 94, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27254980

RESUMEN

Patient- and Family-Centered Care is a core value of The Children's Hospital of Philadelphia (CHOP). Satisfaction/ experience data are closely tracked to assist in determining if hospital staff are partnering effectively with patients and families. When opportunities for improvement were identified within the Nursing Department, an existing institutional model, KIDS CARE, was used to promote change. KIDS CARE was developed to teach and reinforce respectful behaviors for nurses initiating partnerships with patients and families. The Patient Satisfaction Committee partnered with the Family Advisory Council and Shared Governance Council to revise this model to help achieve the goals of improving quality of care. Next steps involved educating patients, families, and staff using innovative multimodal strategies. By engaging in this renewed commitment to Patient- and Family-Centered Care, systems and structures were developed to keep KIDS CARE relevant and make strides toward improved outcomes for patients and families.


Asunto(s)
Modelos de Enfermería , Relaciones Enfermero-Paciente , Personal de Enfermería en Hospital/educación , Satisfacción del Paciente , Enfermería Pediátrica/normas , Guías de Práctica Clínica como Asunto , Relaciones Profesional-Familia , Adolescente , Niño , Preescolar , Hospitales Pediátricos , Humanos , Lactante , Philadelphia , Evaluación de Programas y Proyectos de Salud
3.
Transfus Med Rev ; 21(1): 49-57, 2007 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-17174220

RESUMEN

The administration of blood products is a common, resource-intensive, and potentially problem-prone area that may place patients at elevated risk in the clinical setting. Much of the emphasis in transfusion safety has been targeted toward quality control measures in laboratory settings where blood products are prepared for administration as well as in automation of certain laboratory processes. In contrast, the process of transfusing blood in the clinical setting (ie, at the point of care) has essentially remained unchanged over the past several decades. Many of the currently available methods for improving the quality and safety of blood transfusions in the clinical setting rely on informal process descriptions, such as flow charts and medical algorithms, to describe medical processes. These informal descriptions, although useful in presenting an overview of standard processes, can be ambiguous or incomplete. For example, they often describe only the standard process and leave out how to handle possible failures or exceptions. One alternative to these informal descriptions is to use formal process definitions, which can serve as the basis for a variety of analyses because these formal definitions offer precision in the representation of all possible ways that a process can be carried out in both standard and exceptional situations. Formal process definitions have not previously been used to describe and improve medical processes. The use of such formal definitions to prospectively identify potential error and improve the transfusion process has not previously been reported. The purpose of this article is to introduce the concept of formally defining processes and to describe how formal definitions of blood transfusion processes can be used to detect and correct transfusion process errors in ways not currently possible using existing quality improvement methods.


Asunto(s)
Transfusión Sanguínea , Garantía de la Calidad de Atención de Salud , Administración de la Seguridad , Incompatibilidad de Grupos Sanguíneos/prevención & control , Tipificación y Pruebas Cruzadas Sanguíneas/normas , Humanos , Garantía de la Calidad de Atención de Salud/normas , Seguridad , Administración de la Seguridad/normas , Reacción a la Transfusión
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