Cortical porosity in children is determined by age-dependent osteonal morphology.

INTRODUCTION: Fracture rates in children are high. Cortical bone makes a major contribution to bone strength, determined by cortical geometry, mineralization and porosity. Of these, porosity remains least well explored. Since most cortical canals are part of an osteon, we examined osteons and their canals for age-related changes in numbers, size and shape in 87 iliac crest bone samples of subjects aged 0-25 years, using histomorphometry. RESULTS: Three types of secondary osteons were identified: drifting, eccentric and concentric. 1. Drifting osteons predominated to the mid-teens, were large, asymmetrical, and had giant canals (remodeling space) with the resorption front drifting towards the marrow. The cause of drift remains unclear. Onset of formation appeared delayed, and commenced on the periosteum-facing surface. From the mid-teens numerical density of drifting osteons decreased, and so did porosity. 2. Eccentric osteons were smaller, more circular and had a small excentric canal; their numerical density gradually increased with age. 3. Concentric osteons (adult bone) were the smallest, most symmetrical osteons, had a small central canal, and markedly increased in numerical density from the mid-teens. Boys showed greater overall porosity and greater numerical density of drifting osteons, and later change to concentric osteons than girls. Whites had greater numerical density and greater areal density of resorption cavities than blacks. CONCLUSIONS: Structure of osteons and canals varied during growth. Large asymmetrical drifting osteons with giant active canals (remodeling space) predominated until the mid-teens and accounted for > 70% of childhood cortical porosity. Thereafter smaller concentric (adult type) osteons increasingly predominated. Gender differences may relate to greater fracture rates in boys, and race differences to greater fracture rates in whites. The role of osteocyte-mediated mechanotransduction in osteonal structure and cortical porosity during growth warrants further exploration.

Cortical and trabecular bone microarchitecture and turnover in alcohol-induced chronic pancreatitis: a histomorphometric study.

Alcohol-induced chronic pancreatitis is associated with bone loss, but bone histomorphometric data describing the mechanism of cortical (Ct) and trabecular (Tb) bone loss are scarce. In this case-control study, we investigated 13 black male patients aged 41.2 +/- 8.9 years with alcohol-induced chronic pancreatitis by routine iliac crest cortical and trabecular histomorphometry and by biochemistry relevant to bone, liver function, and iron overload. Patients showed lower values for Ct thickness (P = 0.018), endocortical (Ec) wall thickness (P = 0.0002), Tb bone volume (0.019), Tb thickness (0.001), Tb wall thickness (P < 0.0001), Ec osteoid thickness (P = 0.001), Ec mineral apposition rate (P = 0.011), and Ec bone formation rate (P = 0.035). Ec eroded surface (P = 0.004) was elevated compared to controls. Tb osteoid thickness (P = 0.14) and Tb mineral apposition rate (P = 0.195) tended to be lower than in controls. Levels of 25-hydroxyvitamin D (P < 0.005), serum magnesium (P = 0.02), and ascorbic acid (P = 0.049) were lower and urine calcium/creatinine ratios higher than in controls. Alkaline phosphatase and gamma-glutamyl transpeptidase (GGT) were negatively correlated but iron markers were positively correlated with bone structural and formation variables. The histomorphometric data were found to be consistent with alcohol bone disease. Osteomalacia was not a feature. Secondary pathogenetic factors were liver disease, hypovitaminosis D and C, diabetes mellitus, and possibly chronic pancreatitis.