RESUMEN
As climate targets tighten, all countries must transition toward a renewable electricity system, but conflicts about generation and infrastructure deployment impede transition progress. Although the triggers of opposition are well studied, what people want remains understudied. We survey citizen preferences for a renewable electricity future through a conjoint analysis among 4,103 individuals in Denmark, Portugal, Poland, and Germany. With our study we go beyond the Likert scale survey approach specifically seeking trade-offs and contextualized preferences for regional electricity system designs. We show the importance of identifying both the "least preferred" and "most preferred" solutions and highlighting the possibility of identifying very different systems with identical utility. Lastly, our research actively bridges the divide between social aspects and techno-economic modeling, promoting their integration. We show that the most preferred system design in all four countries is a predominantly regional one, based on rooftop solar, communally owned, and not relying on transmission expansion.
RESUMEN
The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We further showed that LBN targets the hippocampal NG2+ transcriptome with glucocorticoids being an important mediator of the LBN-induced molecular changes. LBN altered the NG2+ transcriptome and these transcriptional effects were correlated with glucocorticoids levels. The functional relevance of one LBN-induced candidate gene, Scn7a, could be confirmed by an increase in the density of voltage-gated sodium (Nav) channel activated currents in hippocampal NG2+ cells. Scn7a remained upregulated until adulthood in LBN animals, which displayed impaired cognitive performance. Considering that Nav channels are important for NG2+ cell-to-neuron communication, our findings provide novel insights into the disruption of this process in LBN mice.
