The Effect of Pregabalin and Methylcobalamin Combination on the Chronic Postthoracotomy Pain Syndrome.

BACKGROUND: Chronic postthoracotomy pain (CPTP) consists of different types of pain. Some characteristics of CPTP are the same as those of recognized neuropathic pain syndromes. We aimed to determine the safety and efficacy of pregabalin and methylcobalamin combination (PG-B12) in comparison with diclofenac potassium (DP) in patients with CPTP. METHODS: One hundred consecutive patients with CPTP after posterolateral/lateral thoracotomy were prospectively randomly assigned and evaluated. Fifty patients were given PG-B12 and another 50 patients were given DP treatment. Visual Analogue Scale (VAS) and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scorings were performed previous to the treatment (day 0) and on the 15th, 30th, 60th, and 90th days. Adverse events were questioned. RESULTS: The mean ages were 58.7 ± 12.2 and 54.6 ± 14.5 years, and the mean durations of pain were 4.01 ± 1.04 and 3.8 ± 1.02 months, respectively. The number of patients with a VAS score less than 5 at the latest follow-up (VAS90 < 5) was 44 (88%) and 18 (36%) in the PG-B12 and DP groups, respectively (p < 0.05). Forty-four patients (88%) in the PG-B12 group and 16 patients (32%) in the DP group had a LANSS score less than 12 at the latest follow-up (p < 0.05). Minor adverse events that did not mandate discontinuation of the treatment were observed in 14 patients (28%) in the PG-B12 group and 2 patients (4%) in the DP group. CONCLUSIONS: PB-B12 is safe and effective in the treatment of CPTP with minimal side effects and a high patient compliance. These results should be supported by multidisciplinary studies with larger sample sizes and longer follow-ups.

A comparison of propofol-midazolam and midazolam alone for sedation in endobronchial ultrasound-guided transbronchial needle aspiration: a retrospective cohort study.

OBJECTIVES: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a new, minimally invasive, bronchoscopic technique used in the evaluation of inthrathoracic lymph nodes.Use of sedation drugs before the procedure differs among centres. There is no standardization about sedation before EBUS-TBNA.We used a policy decision to shift from use of propofol with midazolam vs midazolam alone in a large tertiary hospital to evaluate the diagnostic yield and safety of EBUS-TBNA procedure. METHODS: Files of all the patients who were performed EBUS-TBNA between the dates of September 2010 and May 2014 were surveyed. All the EBUS-TBNA cases were performed under sedation of propofol and midazolam with an accompanying anesthesiologist in the beginning, however, sedation is applied with midazolam without an accompanying anesthesiologist after April 2013 due to changes in sedation policy. The diagnostic yield and complication rates were compared by chi-squared analysis between two groups. RESULTS: The files of 340 EBUS-TBNA performed patients were evaluated. Of the patients 274 eligible patients were analysed. 152 patients who fulfilled the inclusion criteria were analysed in propofol-midazolam (P) sedated group and 122 patients were analysed in midazolam (M) group. There is no statistically significant difference between two different sedated groups in terms of age and gender. Diagnostic value was detected as 77.6% in P group and 85.7% in M group and the difference was not statistically significant. No difference between complication rates of both groups was observed. CONCLUSION: Both sedation-types for performing EBUS-TBNA showed similar diagnostic value and complication rates in our study. Propofol with midazolam application requires with an accompanying anaesthesiologist, therefore, it increases cost. EBUS-TBNA procedures had been performed in safe with no decrease in diagnostic yield under moderate sedation.

A comparison of thoracic or lumbar patient-controlled epidural analgesia methods after thoracic surgery.

BACKGROUND: We aimed to compare patient-controlled thoracic or lumbar epidural analgesia methods after thoracotomy operations. METHODS: One hundred and twenty patients were prospectively randomized to receive either thoracic epidural analgesia (TEA group) or lumbar epidural analgesia (LEA group). In both groups, epidural catheters were administered. Hemodynamic measurements, visual analog scale scores at rest (VAS-R) and after coughing (VAS-C), analgesic consumption, and side effects were compared at 0, 2, 4, 8, 16, and 24 hours postoperatively. RESULTS: The VAS-R and VAS-C values were lower in the TEA group in comparison to the LEA group at 2, 4, 8, and 16 hours after surgery (for VAS-R, P = 0.001, P = 0.01, P = 0.008, and P = 0.029, respectively; and for VAS-C, P = 0.035, P = 0.023, P = 0.002, and P = 0.037, respectively). Total 24-hour analgesic consumption was different between groups (175 +/- 20 mL versus 185 +/- 31 mL; P = 0.034). The comparison of postoperative complications revealed that the incidence of hypotension (21/57, 36.8% versus 8/63, 12.7%; P = 0.002), bradycardia (9/57, 15.8% versus 2/63, 3.2%; P = 0.017), atelectasis (1/57, 1.8% versus 7/63, 11.1%; P = 0.04), and the need for intensive care unit (ICU) treatment (0/57, 0% versus 5/63, 7.9%; P = 0.03) were lower in the TEA group in comparison to the LEA group. CONCLUSIONS: TEA has beneficial hemostatic effects in comparison to LEA after thoracotomies along with more satisfactory pain relief profile.

Video-assisted thoracoscopy for spontaneous pneumothorax after pneumonectomy.

In this paper, we present 3 patients who had previously undergone pneumonectomy and then presented with a spontaneous pneumothorax. The indication for pneumonectomy was tuberculosis and NSCLC in 2 and 1 patient, respectively. The interval between the surgery and development of pneumothorax was 2, 4, and 11 years. On admission, 2 of the 3 patients were in extreme respiratory distress requiring urgent chest tube insertion. In all patients we undertook elective video-assisted thoracoscopy with complete preparation for cardiopulmonary support on the side. Bullectomy and/or diathermy ablation for apical bullae and blebs were performed concomitantly with total parietal pleurectomy. The postoperative course was uneventful in the patients, and they remain on routine follow-up for up to 6-12 months without any complaints. Our experience suggests that emphysematous changes in the remaining lung should be carefully inspected during long-term follow-up after pneumonectomy. Video-assisted thoracoscopic (VAT) pleurectomy appears to be a good option for the management of spontaneous pneumothorax only if it is performed by a dedicated multidisciplinary team with various cardiopulmonary support facilities on the side.

The effects of adding various doses of clonidine to ropivacaine in spinal anesthesia.

OBJECTIVE: In this study, we compared the clinical effects of combined doses of ropivacaine and clonidine. MATERIALS AND METHODS: Seventy-five patients between ages 18 and 75, in ASA I-III groups who were to undergo elective lower extremity surgery, were included in the study with informed consent. Subjects were randomly assigned to 3 groups. Group I: % 1 ropivacaine 12 mg, group II: % 1 ropivacaine 12 mg + clonidine 15 µg, group III: % 1 ropivacaine 12 mg + clonidine 30 µg. Mean arterial pressure, breathing, heart rate and peripheral oxygen saturation, total amount of ephedrine and atropine used, sensory and motor block levels, level of sedation, pain level and complications were monitored. RESULTS: The mean arterial pressure recorded in group III decreased significantly at 75, 105 and 120 min compared to groups I and II. In group I, time to two segment regression and time to sensory block to S2 was shorter when compared to the other groups (P<0.0001). The time to voiding and the duration of motor blockade was significantly longer in group I in comparison to the other groups. The need for atropine in group III was significantly higher (P<0.001). The incidence of hypotension and the requirement for ephedrine were significantly higher in groups II and III as compared to group I (P<0.01). Similarly, sedation in group III was significantly higher compared to the other groups (P<0.05). CONCLUSION: In summary, our study revealed that clonidine can be added to ropivacaine for spinal anesthesia in surgical interventions to obtain deeper and longer sensory and motor block. However, hypotension, bradycardia and sedation should be monitored closely.

A Case Report of a Renal Transplant Patient with Progressive Neurological Disorder due to Tacrolimus.

Neurological complications of tacrolimus are usually mild (tremors, paresthesia, myalgia), however, serious complications that result in encephalopathy, convulsions and coma can be seen. Serious complications are more frequently reported following liver transplants and lungs transplants than renal transplants and are typically seen when tacrolimus concentrations exceed the 15 ng/L therapeutic limit. In this article we presented our case of a renal allograft receiver with nausea, dizziness and fatigue complaints.

Retrospective evaluation of colon injury cases.

OBJECTIVE: When considering abdominal region injuries, the colon is one of the most frequently wounded organs. Due to the septic contents of the colon, failure to treat or improper treatment of colon injuries increases the risk of major complications and may result in death. The aim of our study is a retrospective evaluation of colon injury cases over a 5-year period. MATERIALS AND METHODS: Forty-nine patients with a diagnosis of colon injury were included in the study. The cause of colon injury, injured area, Flint colon injury score, additional organs injured, type of surgical procedure performed, postoperative complications and mortality were evaluated. RESULTS: The most frequent cause of colon injury was cutters (57.2%), followed by firearms (36.7%). The left colon was the most common site of injury (40.8%), followed by the transverse (28.6%) and right colon (20.4%). Primary treatment or resection and primary anastomosis were performed on 38 patients (77.6%), while primary treatment and proximal decompression colostomy were performed on 11 patients (22.4%). Eighteen of the patients (36.7%) experienced major postoperative complications, and 6 patients (12.2%) died. CONCLUSION: The morbidity and mortality of colonic injuries can be reduced by rapid patient transportation, good operational experience, use of wide spectrum antibiotics and postoperative care in an intensive care unit.

The effects of hypertonic saline solution, ascorbic Acid and low-molecular-weight heparin on acute necrotizing pancreatitis in rats.

OBJECTIVE: We investigated the biochemical and histopathological effects of vitamin C, low-molecular-weight heparin (LMWH), and hypertonic solution on acute necrotizing pancreatitis and on lungs as a terminal organ. MATERIALS AND METHODS: We included 48 Sprague-Dawley rats in the study, which were divided into six groups, each with eight rats. The rats in group 1 were sacrificed immediately, in order to determine normal reference values for biochemical and histopathological data. Twenty-four hours after giving intraperitoneal L-arginine to the remaining five groups, development of pancreatitis was shown through assessment of amylase and CRP values. Rats in group 2 were sacrificed at the 24th hour and assigned to the control group for biochemical or the histopathological data groups, in which pancreatitis was induced. The rats in the remaining four groups were given intravenous (IV) isotonic NaCl (group 3), IV vitamin C (group 4), subcutaneous LMWH (group 5), IV hypertonic NaCl (group 6) between 24-48 hours. Each group was assessed with respect to amylase, Serum glutamic oxaloacetic transaminase (SGOT), Lactate dehydrogenase (LDH), C-reactive protein (CRP), bicarbonate, base excess (BE), Ca++, ascorbic acid, and leukocyte at hour 72. Additionally, pancreatic and lung tissue was histopathologically evaluated. RESULTS: In the treatment groups, amylase and leukocyte levels at the 72nd hour were found to be significantly lower than at the 24th hour (p<0.05). The most significant decrease in amylase and leukocyte levels was found in group 6, and damage to the pancreas was found to be lowest in groups 4 and 6. CONCLUSION: We observed that in rats, hypertonic NaCl solution and vitamin C reduced the amount of necrosis in the pancreas.