RESUMEN
We herein present a case of fetal multiple hemivertebrae detected at antenatal sonography. The use of the 3 D technology supported by a new contrast enhancement rendering algorithm (Crystal Vue) has allowed the accurate prenatal classification of the defect, confirmed at follow up, that would have been difficult to define by 2 D only.
Asunto(s)
Imagenología Tridimensional/métodos , Vértebras Lumbares/diagnóstico por imagen , Escoliosis/diagnóstico por imagen , Anomalías Múltiples/diagnóstico por imagen , Anomalías Múltiples/embriología , Aborto Eugénico , Adulto , Femenino , Humanos , Vértebras Lumbares/embriología , Medida de Translucencia Nucal , Embarazo , Costillas/diagnóstico por imagen , Costillas/embriología , Escoliosis/embriología , Ultrasonografía Prenatal/métodosRESUMEN
The effects of intraperitoneal administration of UDP-glucose were studied on male rat gastrocnemius muscle. Muscular glycolytic substrates and metabolites (glycogen, glucose, glucose-6-phosphate, pyruvate, lactate), Krebs' cycle intermediates (citrate, alpha-ketoglutarate, malate), related aminoacids (glutamate, alanine), ammonia, energy store and mediators (creatine phosphate, ATP, ADP, AMP) and the energy charge potential were evaluated. UDP-glucose was administered intraperitoneally at doses of 0.8, 2.0 and 5.0 mg/kg daily for 1, 2 and 4 weeks. The influence of the factors: "dose" of UDP-glucose and "time-course" of treatment was defined. After two weeks, the administration of the three doses tested of UDP-glucose changed the muscular concentration of few glycolytic metabolites, and of some Krebs' cycle intermediates, while after 1 or 4 weeks of treatment there was negligible response.