RESUMEN
Irritable bowel syndrome (IBS) is highly prevalent functional gastrointestinal disorder associated with decrease in quality of life and a high social cost. Diet is one of several therapeutic options in IBS treatment; therefore the development and clinical evaluation of innovative functional food for IBS patients are actual. Instant drink containing 4 g inulin, 4 mg menthol and 2 mg of pyridoxine (in daily dose) has been evaluated. 49 patients 18-68 (41.5±16.5) years old fulfilling the Rome III criteria for IBS-C were randomly assigned into two groups: one received standard diet plus two drinks per day for 2 weeks and control group received standard diet. Response to therapy was recorded daily using Likert scale of abdominal pain, bloating and feeling of incomplete bowel emptying, frequency of bowel movement, Bristol stool scale, and quality of life was assessed by IBSQoL questionnaire before and after the treatment. The consumption of the drink with inulin and menthol contributed to a significant positive effect on the stool parameters (from 0.91±0.73 to 1.12±0.45 bowel movements per day in stool frequency, p=0.05, from 2.68±1.63 to 3.43±1.27 index Bristol scale, p=0.05), reduced the severity of abdominal pain (from 1.78±0.58 to 1.47?0.61 Likert scale points, p=0.05), bloating (from 2.22±0.83 to 1.53±0.71 points ofLikertscale,p= 0.01) and a sense of incomplete bowelemptying (from 2.22 ± 0.88 to 1.61± 0.81 points of Likert scale, p=0.001), as well as increased the quality of life (from 75.3± 12.0 to 83.3±6.7%, p=0.05), but a significant part of patients (10 of 25) complained the appearance of heartburn after the start of the treatment. In conclusion, the consumption of the functional drink containing inulin, menthol and pyridoxine is associated with improve in stool parameters, abdominal pain, Bristol scale index and increase in quality of life in patients with IBS-C, but produce noticeable heartburn. Changes in functional drink composition are needed to reduce adverse effects.
Asunto(s)
Bebidas , Estreñimiento/dietoterapia , Alimentos Funcionales , Síndrome del Colon Irritable/dietoterapia , Necesidades Nutricionales , Valor Nutritivo , Adolescente , Adulto , Anciano , Bebidas/análisis , Colonoscopía , Estreñimiento/complicaciones , Estreñimiento/fisiopatología , Femenino , Motilidad Gastrointestinal/fisiología , Humanos , Inulina/análisis , Síndrome del Colon Irritable/complicaciones , Síndrome del Colon Irritable/fisiopatología , Masculino , Mentol/análisis , Micronutrientes/análisis , Persona de Mediana Edad , Polisacáridos/análisis , Resultado del Tratamiento , Adulto JovenRESUMEN
Irritable bowel syndrome (IBS) is highly prevalent functional gastrointestinal disorder associated with decrease in quality of life and a high social cost. Diet is one of several therapeutic options in IBS treatment; therefore the development and clinical evaluation of innovative functional food for IBS patients is useful. Dry jelly concentrate containing 3 g inulin, 10 mg curcumin and 1.8 mg of pyridoxine was developed and clinically evaluated. Fifty patients fulfilling the Rome III criteria for IBS-C were randomly assigned into two groups: one received standard diet plus two jelly drinks a day for 2 weeks and control group received standard diet. Response to therapy was recorded on a daily basis using Likert scale of abdominal pain, bloating and feeling of incomplete bowel emptying, frequency of bowel movement, Bristol stool scale, and quality of life assessed by IBSQoL questionnaire before and after the treatment. Intake of functional food product (jelly) containing inulin and curcumin is associated with a significant positive effect on the stool parameters (from 0.6±0.24 to 1.15±0.65 t/d in stool frequency, p=0.001, from 2.62±1.23 to 3.99±1.27, index Bristol scale, p=0.001), a reduce of the severity of abdominal pain (from 1.69±0.71 to 1.36±0.44 Likert scale points, p=0.001), bloating (from 2.03±0.89 to 1.55±0.81 points of Likert scale, p=0.02) and a sense of incomplete bowel emptying (from 2.25±0.98 to 1.68±0.92 points of Likert scale, p=0.001), as well as an increase in quality of life (from 64.5±13.5 to 81.2±9.1%, Ñ=0.05). Patients in control group have improvement in abdominal pain (from 2.16±0.58 to 1.8±0.61 Likert scale points, p=0.05) and bloating (from 2.42±0.83 to 2.16±0.71 Likert scale points, p=0.05) only. During the treatment period no significant adverse events were found. These results indicate that jelly concentrate containing inulin, curcumin and pyridoxine improves abdominal pain score, Bristol scale index and quality of life in patients with IBS-C.
Asunto(s)
Bebidas , Estreñimiento , Fibras de la Dieta/administración & dosificación , Síndrome del Colon Irritable , Vitaminas/administración & dosificación , Adulto , Anciano , Estreñimiento/dietoterapia , Estreñimiento/fisiopatología , Curcumina/administración & dosificación , Femenino , Humanos , Inulina/administración & dosificación , Síndrome del Colon Irritable/dietoterapia , Síndrome del Colon Irritable/fisiopatología , Masculino , Persona de Mediana Edad , Piridoxina/administración & dosificaciónRESUMEN
The analysis on the role of major nutrients (proteins, fats and carbohydrates), micronutrients (vitamins and minerals) in a diet of sportsmen is adduced. Requirements for nutrients depend on the volume and intensity of physical exertion during training and competition, not only on the qualifications of sportsmen.
Asunto(s)
Atletas , Ejercicio Físico/fisiología , Alimentos , Femenino , Humanos , Masculino , Medicina Deportiva/métodosRESUMEN
Daily inclusion in the diet of Pskov GRES workers the drinks or kissels containing 2 g pectin per daily serving (cup) during 6 months was accompanied by a statistically significant decline of their supply with vitamins C, B2, A and beta-carotene. This is reflected both in reducing the average vitamin concentration in blood serum and in the increase of the quota of people with deficiency of several vitamins. Additional inclusion of 13 vitamins in these drinks and kissels, in a dose about 80% of the RDA, has prevented the deterioration of vitamin status.
Asunto(s)
Avitaminosis/prevención & control , Bebidas , Pectinas/administración & dosificación , Vitaminas/administración & dosificación , Adulto , Femenino , Humanos , Industrias , Masculino , Persona de Mediana Edad , Pectinas/farmacocinética , Federación de Rusia , Factores de Tiempo , Vitaminas/farmacocinética , beta Caroteno/administración & dosificación , beta Caroteno/farmacocinéticaRESUMEN
The classification and composition of specialized foods for sportsmen are presented. The perspective of application of contemporary biologically active substance to the development of new foods is discussed for nutrition sportsmen.
Asunto(s)
Alimentos Especializados , Deportes , Metabolismo Energético , Alimentos Especializados/clasificación , Alimentos Especializados/normas , Humanos , Micronutrientes , Valor NutritivoRESUMEN
Contemporary domestic and international experience of forming a diet for young athletes involved in various kinds of sport was considered at the article.
Asunto(s)
Necesidades Nutricionales , Deportes , Adolescente , Niño , Carbohidratos de la Dieta/administración & dosificación , Grasas de la Dieta/administración & dosificación , Proteínas en la Dieta/administración & dosificación , Metabolismo Energético , Femenino , Humanos , Masculino , Micronutrientes/administración & dosificación , Valor Nutritivo , Federación de RusiaRESUMEN
Data are presented on the level of stable metabolites of prostacyclin I2-thromboxane A2 system in streptozotocin diabetes mellitus in rats. It is shown that simulation of streptozotocin diabetes mellitus leads to the reduction of 6-ketoprostaglandin F1 alpha content in the aortal wall tissue and blood plasma, and to a rise of thromboxane B2 level and the thromboxane B2/6-ketoprostaglandin F1 alpha ratio in the blood plasma. Inclusion of docosahexaenic and eicosapentaenic acid concentrate into the ration of animals with streptozotocin diabetes mellitus is conducive to normalization of the stable metabolite level in the prostacyclin I2-thromboxane A2 system.
Asunto(s)
Diabetes Mellitus Experimental/metabolismo , Ácidos Docosahexaenoicos/farmacología , Ácido Eicosapentaenoico/farmacología , Epoprostenol/metabolismo , Tromboxano A2/metabolismo , 6-Cetoprostaglandina F1 alfa/sangre , 6-Cetoprostaglandina F1 alfa/metabolismo , Animales , Aorta/metabolismo , Diabetes Mellitus Experimental/sangre , Masculino , Ratas , Tromboxano B2/sangreAsunto(s)
Pulmón/inmunología , Formación de Anticuerpos , Niño , Preescolar , Humanos , Inmunidad Celular , Pulmón/diagnóstico por imagen , Radiografía , SíndromeAsunto(s)
Microondas/uso terapéutico , Pancreatitis/terapia , Adolescente , Niño , Terapia Combinada , Humanos , Terapia por UltrasonidoRESUMEN
Cyclic 3',5'-adenosine monophosphate (cAMP) inhibits the rate of Escherichia coli growth in media with glucose. When the exogenous nucleotide is added, the generation time and the lag phase become longer. These parameters decrease if cAMP is entirely absent from the cya- mutant as compared to the parent cya+ strain. The nucleotide exerts a low activity in media with glycerol. The action of cAMP is highly specific.