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1.
Sci Adv ; 10(5): eadj2407, 2024 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-38295169

RESUMEN

Identifying the microscopic nature of non-equilibrium energy transfer mechanisms among electronic, spin, and lattice degrees of freedom is central to understanding ultrafast phenomena such as manipulating magnetism on the femtosecond timescale. Here, we use time- and angle-resolved photoemission spectroscopy to go beyond the often-used ensemble-averaged view of non-equilibrium dynamics in terms of quasiparticle temperature evolutions. We show for ferromagnetic Ni that the non-equilibrium electron and spin dynamics display pronounced variations with electron momentum, whereas the magnetic exchange interaction remains isotropic. This highlights the influence of lattice-mediated scattering processes and opens a pathway toward unraveling the still elusive microscopic mechanism of spin-lattice angular momentum transfer.

2.
Brachytherapy ; 22(5): 673-685, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37301703

RESUMEN

PURPOSE: The current protocol for use of the image-guided adaptive brachytherapy (IGABT) procedure entails transport of a patient between the treatment room and the 3-D tomographic imaging room after implantation of the applicators in the body, which movement can cause position displacement of the applicator. Moreover, it is not possible to track 3-D radioactive source movement inside the body, even though there can be significant inter- and intra-fractional patient-setup changes. In this paper, therefore, we propose an online single-photon emission computed tomography (SPECT) imaging technique with a combined C-arm fluoroscopy X-ray system and attachable parallel-hole collimator for internal radioactive source tracking of every source position in the applicator. METHODS AND MATERIALS: In the present study, using Geant4 Monte Carlo (MC) simulation, the feasibility of high-energy gamma detection with a flat-panel detector for X-ray imaging was assessed. Further, a parallel-hole collimator geometry was designed based on an evaluation of projection image quality for a 192Ir point source, and 3-D limited-angle SPECT-image-based source-tracking performances were evaluated for various source intensities and positions. RESULTS: The detector module attached to the collimator could discriminate the 192Ir point source with about 3.4% detection efficiency when including the total counts in the entire deposited energy region. As the result of collimator optimization, hole size, thickness, and length were determined to be 0.5, 0.2, and 45 mm, respectively. Accordingly, the source intensities and positions also were successfully tracked with the 3-D SPECT imaging system when the C-arm was rotated within 110° in 2 seconds. CONCLUSIONS: We expect that this system can be effectively implemented for online IGABT and in vivo patient dose verification.


Asunto(s)
Braquiterapia , Humanos , Método de Montecarlo , Braquiterapia/métodos , Estudios de Factibilidad , Tomografía Computarizada de Emisión de Fotón Único/métodos , Fantasmas de Imagen , Tomografía Computarizada por Rayos X
3.
Phys Med Biol ; 68(8)2023 04 03.
Artículo en Inglés | MEDLINE | ID: mdl-36930985

RESUMEN

Objective. The TOol for PArticle Simulation (TOPAS) is a Geant4-based Monte Carlo software application that has been used for both research and clinical studies in medical physics. So far, most users of TOPAS have focused on radiotherapy-related studies, such as modeling radiation therapy delivery systems or patient dose calculation. Here, we present the first set of TOPAS extensions to make it easier for TOPAS users to model medical imaging systems.Approach. We used the extension system of TOPAS to implement pre-built, user-configurable geometry components such as detectors (e.g. flat-panel and multi-planar detectors) for various imaging modalities and pre-built, user-configurable scorers for medical imaging systems (e.g. digitizer chain).Main results. We developed a flexible set of extensions that can be adapted to solve research questions for a variety of imaging modalities. We then utilized these extensions to model specific examples of cone-beam CT (CBCT), positron emission tomography (PET), and prompt gamma (PG) systems. The first of these new geometry components, the FlatImager, was used to model example CBCT and PG systems. Detected signals were accumulated in each detector pixel to obtain the intensity of x-rays penetrating objects or prompt gammas from proton-nuclear interaction. The second of these new geometry components, the RingImager, was used to model an example PET system. Positron-electron annihilation signals were recorded in crystals of the RingImager and coincidences were detected. The simulated data were processed using corresponding post-processing algorithms for each modality and obtained results in good agreement with the expected true signals or experimental measurement.Significance. The newly developed extension is a first step to making it easier for TOPAS users to build and simulate medical imaging systems. Together with existing TOPAS tools, this extension can help integrate medical imaging systems with radiotherapy simulations for image-guided radiotherapy.


Asunto(s)
Programas Informáticos , Tomografía Computarizada por Rayos X , Humanos , Simulación por Computador , Protones , Algoritmos , Método de Montecarlo
4.
Nat Commun ; 13(1): 2741, 2022 May 18.
Artículo en Inglés | MEDLINE | ID: mdl-35585096

RESUMEN

Time-resolved momentum microscopy provides insight into the ultrafast interplay between structural and electronic dynamics. Here we extend orbital tomography into the time domain in combination with time-resolved momentum microscopy at a free-electron laser (FEL) to follow transient photoelectron momentum maps of excited states of a bilayer pentacene film on Ag(110). We use optical pump and FEL probe pulses by keeping FEL source conditions to minimize space charge effects and radiation damage. From the momentum microscopy signal, we obtain time-dependent momentum maps of the excited-state dynamics of both pentacene layers separately. In a combined experimental and theoretical study, we interpret the observed signal for the bottom layer as resulting from the charge redistribution between the molecule and the substrate induced by excitation. We identify that the dynamics of the top pentacene layer resembles excited-state molecular dynamics.

5.
J Appl Clin Med Phys ; 23(1): e13448, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34633736

RESUMEN

PURPOSE: Tetrahedral mesh (TM)-based computational human phantoms have recently been developed for evaluation of exposure dose with the merit of precisely representing human anatomy and the changing posture freely. However, conversion of recently developed TM phantoms to the Digital Imaging and Communications in Medicine (DICOM) file format, which can be utilized in the clinic, has not been attempted. The aim of this study was to develop a technique, called TET2DICOM, to convert the TM phantoms to DICOM datasets for accurate treatment planning. MATERIALS AND METHODS: The TM phantoms were sampled in voxel form to generate the DICOM computed tomography images. The DICOM-radiotherapy structure was defined based on the contour data. To evaluate TET2DICOM, the shape distortion of the TM phantoms during the conversion process was assessed, and the converted DICOM dataset was implemented in a commercial treatment planning system (TPS). RESULTS: The volume difference between the TM phantoms and the converted DICOM dataset was evaluated as less than about 0.1% in each organ. Subsequently, the converted DICOM dataset was successfully implemented in MIM (MIM Software Inc., Cleveland, USA, version 6.5.6) and RayStation (RaySearch Laboratories, Stockholm, Sweden, version 5.0). Additionally, the various possibilities of clinical application of the program were confirmed using a deformed TM phantom in various postures. CONCLUSION: In conclusion, the TM phantom, currently the most advanced computational phantom, can be implemented in a commercial TPS and this technique can enable various TM-based applications, such as evaluation of secondary cancer risk in radiotherapy.


Asunto(s)
Planificación de la Radioterapia Asistida por Computador , Tomografía Computarizada por Rayos X , Humanos , Fantasmas de Imagen , Programas Informáticos , Suecia
6.
Phys Med Biol ; 66(18)2021 09 14.
Artículo en Inglés | MEDLINE | ID: mdl-34384063

RESUMEN

Monte Carlo (MC) simulations play an important role in radiotherapy, especially as a method to evaluate physical properties that are either impossible or difficult to measure. For example, MC simulations (MCSs) are used to aid in the design of radiotherapy devices or to understand their properties. The aim of this article is to review the MC method for device simulations in radiation therapy. After a brief history of the MC method and popular codes in medical physics, we review applications of the MC method to model treatment heads for neutral and charged particle radiation therapy as well as specific in-room devices for imaging and therapy purposes. We conclude by discussing the impact that MCSs had in this field and the role of MC in future device design.


Asunto(s)
Diagnóstico por Imagen , Planificación de la Radioterapia Asistida por Computador , Método de Montecarlo , Dosificación Radioterapéutica
7.
J Appl Clin Med Phys ; 22(6): 104-118, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34036701

RESUMEN

The present study verified and evaluated the dosimetric effects of protons scattered from a snout and an aperture in clinical practice, when a range compensator was included. The dose distribution calculated by a treatment planning system (TPS) was compared with the measured dose distribution and the dose distribution calculated by Monte Carlo simulation at several depths. The difference between the measured and calculated results was analyzed using Monte Carlo simulation with filtration of scattering in the snout and aperture. The dependence of the effects of scattered protons on snout size, beam range, and minimum thickness of the range compensator was also investigated using the Monte Carlo simulation. The simulated and measured results showed that the additional dose compared with the results calculated by the TPS at shallow depths was mainly due to protons scattered by the snout and aperture. This additional dose was filtered by the structure of the range compensator so that it was observed under the thin region of the range compensator. The maximum difference was measured at a depth of 16 mm (8.25%), with the difference decreasing with depth. Analysis of protons contributing to the additional dose showed that the contribution of protons scattered from the snout was greater than that of protons scattered from the aperture when a narrow snout was used. In the Monte Carlo simulation, this effect of scattered protons was reduced when wider snouts and longer-range proton beams were used. This effect was also reduced when thicker range compensator bases were used, even with a narrow snout. This study verified the effect of scattered protons even when a range compensator was included and emphasized the importance of snout-scattered protons when a narrow snout is used for small fields. It indicated that this additional dose can be reduced by wider snouts, longer range proton beams, and thicker range compensator bases. These results provide a better understanding of the additional dose from scattered protons in clinical practice.


Asunto(s)
Terapia de Protones , Simulación por Computador , Humanos , Método de Montecarlo , Protones , Radiometría , Dosificación Radioterapéutica , Planificación de la Radioterapia Asistida por Computador
8.
Phys Rev Lett ; 126(13): 136401, 2021 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-33861118

RESUMEN

Samarium hexaboride is a candidate for the topological Kondo insulator state, in which Kondo coherence is predicted to give rise to an insulating gap spanned by topological surface states. Here we investigate the surface and bulk electronic properties of magnetically alloyed Sm_{1-x}M_{x}B_{6} (M=Ce, Eu), using angle-resolved photoemission spectroscopy and complementary characterization techniques. Remarkably, topologically nontrivial bulk and surface band structures are found to persist in highly modified samples with up to 30% Sm substitution and with an antiferromagnetic ground state in the case of Eu doping. The results are interpreted in terms of a hierarchy of energy scales, in which surface state emergence is linked to the formation of a direct Kondo gap, while low-temperature transport trends depend on the indirect gap.

9.
Phys Med Biol ; 65(10): 105005, 2020 05 22.
Artículo en Inglés | MEDLINE | ID: mdl-32235068

RESUMEN

An accurate knowledge of in vivo proton dose distribution is key to fully utilizing the potential advantages of proton therapy. Two representative indirect methods for in vivo range verification, namely, prompt gamma (PG) imaging and positron emission tomography (PET), are available. This study proposes a PG-PET system that combines the advantages of these two methods and presents detector geometry and background reduction techniques optimized for the PG-PET system. The characteristics of the secondary radiations emitted by a water phantom by interaction with a 150 MeV proton beam were analysed using Geant4.10.00, and the 2-D PG distributions were obtained and assessed for different detector geometries. In addition, the energy window (EW), depth-of-interaction (DOI), and time-of-flight (TOF) techniques are proposed as the background reduction techniques. To evaluate the performance of the PG-PET system, the 3-D dose distribution in the water phantom caused by two proton beams of energies 80 MeV and 100 MeV was verified using 16 optimal detectors. The thickness of the parallel-hole tungsten collimator of pitch 8 mm and width 7 mm was determined as 200 mm, and that of the GAGG scintillator was determined as 30 mm, by an optimization study. Further, 3-7 MeV and 2-7 MeV were obtained as the optimal EWs when the DOI and both the DOI and TOF techniques were applied for data processing, respectively; the detector performances were improved by about 38% and 167%, respectively, compared with that when applying only the 3-5 MeV EW. In this study, we confirmed that the PG distribution can be obtained by simply combining the 2-D parallel hole collimator and the PET detector module. In the future, we will develop an accurate 3-D dose evaluation technique using deep learning algorithms based on the image sets of dose, PG, and PET distributions for various proton energies.


Asunto(s)
Método de Montecarlo , Tomografía de Emisión de Positrones , Terapia de Protones , Dosis de Radiación , Algoritmos , Humanos , Fantasmas de Imagen , Dosificación Radioterapéutica , Agua
10.
Appl Radiat Isot ; 156: 109010, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32056690

RESUMEN

In this study, we validated the feasibility of an energy weighted algorithm that highlights a characteristic area including the Compton edge as a single peak in a proof-of-principle radiation portal monitor system with a plastic scintillator measuring 50 × 100 × 5 cm3. We measured the energy weighted spectra with steel shielding and the dynamic movements of the 137Cs and 60Co sources. The results showed that the peak locations of each source could be identified under shielded or dynamic motion conditions, each within a maximum difference of 0.08 MeV.

11.
Appl Radiat Isot ; 154: 108851, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31527010

RESUMEN

Since higher dose delivered to a semiconductor leads to more functional loss to the device, accurate dose evaluation of the semiconductor is very important to reduce the defect rate during x-ray inspection. The aim of this study is to develop the technique to accurately evaluate the absorbed dose to the semiconductor using the Monte Carlo method. The x-ray radiographic system was modeled based on the Geant4 Monte Carlo tool-kit. The Monte Carlo commissioning was performed by comparing the energy spectrum between the simulation and measurement. The dose evaluation technique for the semiconductor was developed, and the dose delivered to the semiconductor device was evaluated according to various x-ray energies. The energy spectrum of the x-ray beam simulated with Geant4 was validated with the experiment using the CdTe detector for various x-ray beams. The accurate dose to the semiconductor component was assessed according to various x-ray energies. The x-rays of 25 keV energy delivered the highest dose to the silicon die, while the 67.5 keV showed the minimum dose to the die. It was observed that the higher energy over about 70 keV also increased the dose with the scattered photons produced in the solder ball and circuit board. The technique to accurately determine the absorbed dose in the semiconductor was suggested and the x-ray energy deliver the high dose to the semiconductor die was assessed. These results could be fundamentally used to reduce the dose in semiconductor and defect rate in x-ray inspection.

12.
Appl Radiat Isot ; 154: 108860, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31442799

RESUMEN

This study aims to evaluate the annual effective dose from a sleeping mattress containing naturally occurring radioactive material (NORM). In this study, the dose rate was measured using two different portable radiation detectors, namely the Geiger Müller (GM) tube and portable high-purity germanium (HPGe) detector; the annual effective dose was calculated using annualized usage of the products, and the equivalent does was evaluated via Monte Carlo (MC) simulation and using the model of the human body, which is known as a computational human phantom. The dose rate of the product, excluding background radiation at the shielded room, was measured as 0.22 and 0.13 µSv/h in the GM-tube and portable HPGe, respectively. Assuming that the sleeping mattress was used for an average sleeping of 8 h/day, the annual effective dose was calculated as 0.64 and 0.38 mSv/y using the GM-tube and portable HPGe detectors, respectively. Also, the annual effective dose calculated using MC simulation and radioactivity values from the nuclides analysis was 0.13 mSv/y. The annual effective dose calculated using the two different portable detectors and MC simulation is less than the annual effective dose limit for the general public, which is set at 1 mSv/y. This technique could be used not only for the safety regulation for products containing NORM but also for the accurate evaluation of the effective dose for radiation workers in the diverse radiation field.


Asunto(s)
Seguridad de Productos para el Consumidor , Exposición a la Radiación/análisis , Lechos/efectos adversos , Simulación por Computador , Humanos , Imagenología Tridimensional , Método de Montecarlo , Fantasmas de Imagen , Dosis de Radiación , Exposición a la Radiación/efectos adversos , Radiactividad , Radiometría/métodos , Radiometría/estadística & datos numéricos , República de Corea
13.
Phys Med Biol ; 64(16): 165005, 2019 08 14.
Artículo en Inglés | MEDLINE | ID: mdl-31269480

RESUMEN

Incorrect prediction of skin dose in external beam radiotherapy (EBR) can have normal tissue complication such as acute skin desquamation and skin necrosis. The absorbed dose of skin should be evaluated within basal layer, placed between the epidermis and dermis layers. However, current treatment planning systems (TPS) cannot correctly define the skin layer because of the limitation of voxel resolution in computed tomography (CT). Recently, a new tetrahedral-mesh (TM) phantom was developed to evaluate radiation dose realistically. This study aims to develop a technique to evaluate realistic skin dose using the TM phantom in EBR. The TM phantom was modeled with thin skin layers, including the epidermis, basal layer, and dermis from CT images. Using the Geant4 toolkit, the simulation was performed to evaluate the skin dose according to the radiation treatment conditions. The skin dose was evaluated at a surface depth of 50 µm and 2000 µm. The difference in average skin dose between depths was up to 37%, depending on the thickness and region of the skin to be measured. The results indicate that the skin dose has been overestimated when the skin is evaluated using commercial TPS. Although it is not possible with traditional TPS, our skin dose evaluation technique can realistically express the absorbed dose at thin skin layers from a patient-specific phantom.


Asunto(s)
Simulación por Computador , Método de Montecarlo , Fantasmas de Imagen , Planificación de la Radioterapia Asistida por Computador/métodos , Piel/efectos de la radiación , Humanos , Dosificación Radioterapéutica , Piel/diagnóstico por imagen , Tomografía Computarizada por Rayos X
14.
Med Phys ; 46(7): 3285-3297, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31055830

RESUMEN

PURPOSE: The complex beam delivery techniques for patient treatment using a clinical linear accelerator (linac) may result in variations in the photon spectra, which can lead to dosimetric differences in patients that cannot be accounted for by current treatment planning systems (TPSs). Therefore, precise knowledge of the fluence and energy spectrum (ES) of the therapeutic beam is very important. However, owing to the high energy and flux of the beam, the ES cannot be measured directly, and validation of the spectrum modeled in the TPS is difficult. The aim of this study is to develop an efficient beam transmission measurement procedure for accurately reconstructing the ES of a therapeutic x-ray beam generated by a clinical linac. METHODS: The attenuation of a 6 MV photon beam from an Elekta Synergy Platform clinical linac through different thicknesses of graphite and lead was measured using an ion chamber. The response of the ion chamber as a function of photon energy was obtained using the Monte Carlo (MC) method in the Geant4 simulation code. Using the curves obtained in the photon beam transmission measurements and the ion chamber energy response, the ES was reconstructed using an iterative algorithm based on a mathematical model of the spectrum. To evaluate the accuracy of the spectrum reconstruction method, the reconstructed ES (ESrecon ) was compared to that determined by the MC simulation (ESMC ). RESULTS: The ion chamber model in the Geant4 simulation was well validated by comparing the ion chamber perturbation factors determined by the TRS-398 calibration protocol and EGSnrc; the differences were within 0.57%. The number of transmission measurements was optimized to 10 for efficient spectrum reconstruction according to the rate of increase in the spectrum reconstruction accuracy. The distribution of ESrecon obtained using the measured transmission curves was clearly similar to the reference, ESMC , and the dose distributions in water calculated using ESrecon and ESMC were similar within a 2% local difference. However, in a heterogeneous medium, the dose discrepancy between them was >5% when a complex beam delivery technique composed of 171 control points was used. CONCLUSIONS: The proposed measurement procedure required a total time of approximately 1 h to obtain and analyze 20 transmission measurements. In addition, it was confirmed that the transmission curve of high-Z materials influences the accuracy of spectrum reconstruction more than that of low-Z materials. A well-designed transmission measurement protocol suitable for clinical environments could be an essential tool for better dosimetric accuracy in patient treatment and for periodic verification of the beam quality.


Asunto(s)
Aceleradores de Partículas , Fotones , Fenómenos Físicos , Algoritmos , Modelos Teóricos , Radiometría
15.
Phys Rev Lett ; 122(11): 116402, 2019 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-30951331

RESUMEN

The monopnictides TaAs and TaP are well-established Weyl semimetals. Yet, a precise assignment of Fermi arcs, accommodating the predicted chiral charge of the bulk Weyl points, has been difficult in these systems, and the topological character of different surface features in the Fermi surface is not fully understood. Here, employing a joint analysis from linear dichroism in angle-resolved photoemission and first-principles calculations, we unveil the orbital texture on the full Fermi surface of TaP(001). We observe pronounced switches in the orbital texture at the projected Weyl nodes, and show how they facilitate a topological classification of the surface band structure. Our findings establish a critical role of the orbital degrees of freedom in mediating the surface-bulk connectivity in Weyl semimetals.

16.
J Appl Clin Med Phys ; 20(2): 94-106, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30672648

RESUMEN

Despite the improvements in the dose calculation models of the commercial treatment planning systems (TPS), their ability to accurately predict patient dose is still limited. One of the limitations is caused by the simplified model of the multileaf collimator (MLC). The aim of this study was to develop a Monte Carlo (MC) method-based independent patient dose validation system with an elaborate MLC model for more accurate dose evaluation. Varian Clinac 2300 IX was simulated using Geant4 toolkits, after which MC commissioning with measurements was performed to validate the simulation model. A DICOM-RT interface was developed to obtain the beam delivery conditions including the hundreds of MLC motions. Finally, the TPS dose distributions were compared with the MC dose distributions for water phantom cases and a patient case. Our results show that the TPS overestimated the absolute abutting leakage dose in the closed MLC field, with about 20% more of the maximum dose than that of the MC calculation. For water phantom cases, the dose distributions inside the target region were almost identical with the dose difference of less than 2%, while the dose near the edge of the target shows difference about 10% between Geant4 and TPS due to geometrical differences in MLC model. For the patient analysis, the Geant4 and TPS doses of all organs were matched well within 1.4% of the prescribed dose. However, for organs located in areas with high ratio of leaf pairs with distances less than 10 mm leaf pair (LP(<10mm) ), the maximum dose of TPS was overestimated by about 3% of the prescribed dose. These dose comparison results demonstrate that our system for calculating the patient dose is quite accurate. Furthermore, if the MLC sequences in treatment plan have a large ratio of LP(short) , more than 3% dose difference in normal tissue could be seen.


Asunto(s)
Simulación por Computador , Método de Montecarlo , Neoplasias/radioterapia , Fantasmas de Imagen , Radiometría/instrumentación , Planificación de la Radioterapia Asistida por Computador/métodos , Radioterapia de Intensidad Modulada/métodos , Algoritmos , Humanos , Órganos en Riesgo/efectos de la radiación , Radiometría/métodos , Dosificación Radioterapéutica , Radioterapia de Intensidad Modulada/instrumentación
17.
Radiat Oncol ; 13(1): 176, 2018 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-30217160

RESUMEN

BACKGROUND: To measure the absorbed dose rate to water and penumbra of a Gamma Knife® (GK) using a polymethyl metacrylate (PMMA) phantom. METHODS: A multi-purpose PMMA phantom was developed to measure the absorbed dose rate to water and the dose distribution of a GK. The phantom consists of a hemispherical outer phantom, one exchangeable cylindrical chamber-hosting inner phantom, and two film-hosting inner phantoms. The radius of the phantom was determined considering the electron density of the PMMA such that it corresponds to 8 g/cm2 water depth, which is the reference depth of the absorbed dose measurement of GK. The absorbed dose rate to water was measured with a PTW TN31010 chamber, and the dose distributions were measured with radiochromic films at the calibration center of a patient positioning system of a GK Perfexion. A spherical water-filled phantom with the same water equivalent depth was constructed as a reference phantom. The dose rate to water and dose distributions at the center of a circular field delimited by a 16-mm collimator were measured with the PMMA phantom at six GK Perfexion sites. RESULTS: The radius of the PMMA phantom was determined to be 6.93 cm, corresponding to equivalent water depth of 8 g/cm2. The absorbed dose rate to water was measured with the PMMA phantom, the spherical water-filled phantom and a commercial solid water phantom. The measured dose rate with the PMMA phantom was 1.2% and 1.8% higher than those measured with the spherical water-filled phantom and the solid water phantom, respectively. These differences can be explained by the scattered photon contribution of PMMA off incoming 60Co gamma-rays to the dose rate. The average full width half maximum and penumbra values measured with the PMMA phantom showed reasonable agreement with two calculated values, one at the center of the PMMA phantom (LGP6.93) and other at the center of a water sphere with a radius of 8 cm (LGP8.0) given by Leksell Gamma Plan using the TMR10 algorithm. CONCLUSIONS: A PMMA phantom constructed in this study to measure the absorbed dose rates to water and dose distributions of a GK represents an acceptable and practical alternative for GK dosimetry considering its cost-effectiveness and ease of handling.


Asunto(s)
Dosimetría por Película , Fantasmas de Imagen , Polimetil Metacrilato , Control de Calidad , Radiocirugia/normas , Algoritmos , Diseño de Equipo , Humanos , Radiocirugia/instrumentación , Agua
18.
Phys Med ; 51: 117-124, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29914795

RESUMEN

Leksell GammaPlan was specifically designed for Gamma Knife (GK) radiosurgery planning, but it has limited accuracy for estimating the dose distribution in inhomogeneous areas, such as the embolization of arteriovenous malformations. We aimed to develop an independent patient dose validation system based on a patient-specific model, constructed using a DICOM-RT interface and the Geant4 toolkit. Leksell Gamma Knife Perfexion was designed in Geant4.10.00 and includes a DICOM-RT interface. Output factors for each collimator in a sector and dose distributions in a spherical water phantom calculated using a Monte Carlo (MC) algorithm were compared with the output factors calculated by the tissue maximum ratio (TMR) 10 algorithm and dose distributions measured using film, respectively. Studies using two types of water phantom and two patient simulation cases were evaluated by comparing the dose distributions calculated by the MC, the TMR and the convolution algorithms. The water phantom studies showed that if the beam size is small and the target is located in heterogeneous media, the dose difference could be up to 11%. In the two patient simulations, the TMR algorithm overestimated the dose by about 4% of the maximum dose if a complex and large bony structure was located on the beam path, whereas the convolution algorithm showed similar results to those of the MC algorithm. This study demonstrated that the in-house system could accurately verify the patient dose based on full MC simulation and so would be useful for patient cases where the dose differences are suspected.


Asunto(s)
Método de Montecarlo , Dosis de Radiación , Radiocirugia/instrumentación , Fantasmas de Imagen , Dosificación Radioterapéutica
19.
Appl Radiat Isot ; 139: 1-6, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-29677562

RESUMEN

The aim of this study is to develop the Effective Dose Calculation Program (EDCP) for the usage of Naturally Occurring Radioactive Material (NORM) added consumer products. The EDCP was developed based on a database of effective dose conversion coefficient and the Matrix Laboratory (MATLAB) program to incorporate a Graphic User Interface (GUI) for ease of use. To validate EDCP, the effective dose calculated with EDCP by manually determining the source region by using the GUI and that by using the reference mathematical algorithm were compared for pillow, waist supporter, eye-patch and sleeping mattress. The results show that the annual effective dose calculated with EDCP was almost identical to that calculated using the reference mathematical algorithm in most of the assessment cases. With the assumption of the gamma energy of 1 MeV and activity of 1 MBq, the annual effective doses of pillow, waist supporter, sleeping mattress, and eye-patch determined using the reference algorithm were 3.444 mSv year-1, 2.770 mSv year-1, 4.629 mSv year-1, and 3.567 mSv year-1, respectively, while those calculated using EDCP were 3.561 mSv year-1, 2.630 mSv year-1, 4.740 mSv year-1, and 3.780 mSv year-1, respectively. The differences in the annual effective doses were less than 5%, despite the different calculation methods employed. The EDCP can therefore be effectively used for radiation protection management in the context of the usage of NORM-added consumer products. Additionally, EDCP can be used by members of the public through the GUI for various studies in the field of radiation protection, thus facilitating easy access to the program.


Asunto(s)
Radiación de Fondo/efectos adversos , Seguridad de Productos para el Consumidor , Dosis de Radiación , Protección Radiológica , Algoritmos , Ropa de Cama y Ropa Blanca/efectos adversos , Vestuario/efectos adversos , Bases de Datos Factuales , Femenino , Humanos , Masculino , Exposición a la Radiación/estadística & datos numéricos , República de Corea , Programas Informáticos
20.
Sci Rep ; 7(1): 11980, 2017 09 20.
Artículo en Inglés | MEDLINE | ID: mdl-28931836

RESUMEN

Paramagnetic heavy fermion insulators consist of fully occupied quasiparticle bands inherent to Fermi liquid theory. The gap emergence below a characteristic temperature is the ultimate sign of coherence for a many-body system, which in addition can induce a non-trivial band topology. Here, we demonstrate a simple and efficient method to compare a model study and an experimental result for heavy fermion insulators. The temperature dependence of the gap formation in both local moment and mixed valence regimes is captured within the dynamical mean field (DMFT) approximation to the periodic Anderson model (PAM). Using the topological coherence temperature as the scaling factor and choosing the input parameter set within the mixed valence regime, we can unambiguously link the theoretical energy scales to the experimental ones. As a particularly important result, we find improved consistency between the scaled DMFT density of states and the photoemission near-gap spectra of samarium hexaboride (SmB6).

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