The impact of interpersonal reporting heterogeneity on cross-country differences in Healthy Life Years in Europe.

BACKGROUND: The European Union has used Healthy Life Years (HLY) as an indicator to monitor the health of its aging populations. Scholarly and popular interest in HLY across countries has grown, particularly regarding the ranking of countries. It is important to note that HLY is based on self-assessments of activity limitations, raising the possibility that it might be influenced by differences in health reporting behaviours between populations, a phenomenon known as differential item functioning (DIF). METHODS: We estimated DIF-adjusted HLY at age 50 for Belgium, France, Germany, Greece, Italy, the Netherlands, Spain, and Sweden to determine the extent to which differences in HLY might be influenced by reporting heterogeneity across countries. We used anchoring vignettes, taken from the 2004 Survey of Health, Ageing and Retirement in Europe, to estimate DIF-adjusted prevalence rates of activity limitations measured by the Global Activity Limitations Indicator (GALI). The Sullivan method was used to calculate DIF-adjusted HLY. RESULTS: Changes in HLY before and after adjustment ranged from a 1.20-year decrease for men in Italy to a 1.61-year increase for women in Spain. Adjustment for DIF produced changes in the rankings of the countries by HLY, with upward and downward movements of up to three positions. CONCLUSION: Our results show that DIF is likely to affect HLY estimates, thereby posing a challenge to the validity of comparisons of HLY across European countries. The findings suggest that HLY should be used to monitor population health status within a country, rather than to make comparisons across countries.

Subjective Well-Being and Active Life Expectancy in Japan: Evidence From a Longitudinal Study.

Background and Objectives: Existing research has suggested that older adults in Japan enjoy phenomenal physical health status, but they have poor subjective well-being (SWB). Limited empirical evidence exists, however, on how physical health and SWB intersect and are linked to the lives of older men and women in Japan. Using the concept of health expectancy, this study examines the role of SWB, as measured by life satisfaction, in the mortality and morbidity experiences of Japanese adults aged 65 years and older. Research Design and Methods: We used the nationally representative Nihon University Japanese Longitudinal Study of Aging, 1999-2009. Our measurement of morbidity is disability, based on difficulty in activities in daily living (ADLs) and instrumental ADLs. We use the Interpolation of Markov Chains approach to compute life expectancy (LE), LE without disability (active LE), and LE with differing severity of disability for those who are satisfied with life and for those who are not. Results: We documented significant differences in LE and active LE by the state of life satisfaction among older adults in Japan. Men and women who are satisfied with life are expected to live longer and spend more years without having disability compared to those who are not satisfied. We found no differences in the length of life with disability of differing severity by the state of life satisfaction. Discussion and Implications: Our results highlight the important role of SWB at older ages in Japan, because it is directly related to the physical health of its aging population. Fully understanding the health of the older population requires research that focuses on both objective and subjective dimensions of well-being.

Changes in Health Expectancy for Older Adults in Japan: Results from Two Longitudinal Surveys.

BACKGROUND: Although there is evidence of improvements in health expectancy among the Japanese population, existing estimates are based on the prevalence of morbidity taken from cross-sectional survey data. OBJECTIVES: This study employed a multistate life table approach to compute incidence-based health expectancy measures, namely active and inactive life expectancy (LE), for two longitudinal survey cohorts from 1990 to 2009. METHODS: This study used data from two longitudinal surveys of older adults in Japan: the National Survey of the Japanese Elderly (1990-1999) and the Nihon University Japanese Longitudinal Study of Aging (1999-2009). We employed the Interpolation of Markov Chains technique to compute the number of years at age 65 years to be spent with and without difficulty in performing activities of daily living (ADLs) or instrumental ADLs. RESULTS: We documented significant increases in active LE for men and women at age 65 years over the 10-year study period. There were significant changes in total LE for men and in the percentage of active life for women. Inactive LE did not significantly change across the two survey cohorts during the study period. CONCLUSIONS: Our results show that the health status of older adults in Japan has largely improved over the 10-year study period, with increases in both the duration of life and time spent in an active state. This finding offers evidence of compression of morbidity among older men and women in Japan.

Trends in happy life expectancy in Russia, 1994-2015.

Although the physical health status of the Russian population has improved over time, limited attention has been paid to the role of subjective well-being (SWB), and even less is known about its relationship with objective health conditions. Using the concept of health expectancy, this study estimates the number of years expected to be satisfied with life (happy life expectancy [LE]) for Russian men and women aged 50 years and older between 1994 and 2015. Data on age-specific prevalence rates of life satisfaction were obtained from the Russian Longitudinal Study of Higher School of Economics (RLMS-HSE), and the life tables were from the Human Life Table Database. We also tested the correlation between macroeconomic indicators and happy LE at age 50. Results based on the Sullivan method demonstrated substantial increases in happy LE at age 50 for both genders during the study period. Changes in happy LE and the percentage of happy life were significant for both genders. Furthermore, happy LE fluctuated during the 1990s but increased in the early 2000s. Importantly, the results from more recent years show stagnation and slight declines in happy LE for men and women. We also noted correlations between happy LE at age 50 and macroeconomic indicators, including gross domestic product (GDP), inflation, unemployment, and poverty rates. Taken together, the findings suggest that Russian men and women are becoming more satisfied with life as they live longer. While health has mainly been measured by mortality and morbidity in the Russian context, the finding suggests the importance of focusing more on the positive aspect of population health.

The Role of Underweight in Active Life Expectancy Among Older Adults in Japan.

OBJECTIVES: It is underweight, rather than overweight or obesity, that has been a pressing public health concern in Japan. This study examines the impact of being underweight on the health of older Japanese men and women, measured by active life expectancy at age 65. Following the Japanese government's guideline, underweight in this study is defined using the body mass index (BMI) value of 20. METHOD: Data came from five waves (1999-2009) of the Nihon University Japanese Longitudinal Study of Aging (NUJLSOA). We used the Interpolation of Markov Chain approach to estimate the number of years underweight (BMI < 20), normal weight (20 < BMI < 25), and overweight (25 < BMI) individuals were expected to live without difficulty in activities of daily living (ADLs) or instrumental ADLs. RESULTS: We found differences in life and health expectancies across the three weight categories. Underweight people were expected to live the shortest lives and spend the fewest years in an active state compared with normal and overweight individuals. Results remained unchanged even when accounting for educational attainment, smoking history, and a count of existing chronic conditions. DISCUSSION: Being underweight is associated with poor quality of life lived among Japanese older adults. This finding suggests the importance of maintaining proper weight and avoids nutritional risks at advanced ages.

Disasters and the Disablement Process framework: an analysis of the great east Japan earthquake and tsunami of 2011.

This study used the Disablement Process framework to examine how exposure to the great east Japan earthquake and tsunami on 11 March 2011 was related to elders' experiences of disability-that is, 'a gap between personal capability and environmental demand' (Verbrugge and Jette, 1994, p. 1). Data were derived from two waves (2009 and 2013) of the Nihon University Japanese Longitudinal Study of Aging, involving a representative sample of citizens aged 65 or more. Logistic regression was employed to model how the disaster was associated with the prevalence and incidence of disability. A significant relationship was documented between the two. Those impacted by the event exhibited greater odds of reporting a disability in 2013 and developing one between 2009 and 2013. Disasters destroy social infrastructure and disrupt daily life, widening the lacuna between the environment and personal resources. Given the increasing number of disasters, more policy attention should be directed to reducing their adverse consequences for health.

Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase.

Two types of haloperidol prodrugs in which a chemical modification was carried out on the hydroxyl group or carbonyl group were synthesized, and their metabolic activation abilities were evaluated in a human liver microsome (HLM) solution, a human small intestine microsome (HIM) solution and solutions of human recombinant carboxylesterases (hCESs). The metabolic activation rates of alcohol ester prodrugs in HLM solution were similar to those in hCES2 solution, and haloperidol pentanoate and haloperidol hexanoate showed high metabolic activation rates in the synthesized alcohol ester prodrugs. In addition, haloperidol acetate and haloperidol 2-methylbutanoate were hydrolyzed as slowly as haloperidol decanoate. The results suggested that haloperidol prodrugs with a small chain or a branched chain are useful as prodrugs for sustained release. The metabolic activation rate of the enol ester prodrug in HLM solution was similar to that in hCES1 solution, and the enol ester prodrug was found to behave differently from alcohol ester prodrugs, which were metabolically activated by hCES2.

An analysis of factors related to disability-free life expectancy at 65 years of age across Japanese prefectures in 2010.

Compared to the large volume of research focused on mortality differentials within Japan, relatively little is known about regional variations in health expectancy, particularly among older people. This article has two interrelated objectives. The first objective is to estimate prefecture-specific disability-free life expectancy (DFLE) at 65 years of age in 2010. DFLE at 65 by gender and prefecture was computed using the Sullivan method, which was applied to prefecture-specific life tables and prevalence of disability from Kokumin Seikatsu Kiso Chosa (Comprehensive Survey of Living Conditions) of 2010. The second objective is to investigate macro-level factors associated with DFLE at 65 across 47 Japanese prefectures. Our results indicate regional disparities in DFLE at older ages. Importantly, we note close relationships between a prefecture's wealth, labor, and welfare characteristics and DFLE at 65. Income per capita, the proportion of workers older than 65, and welfare expenditures are positively related to DFLE, whereas unemployment and long-term care insurance expenditures per-capita are inversely associated with DFLE for both genders. The proportion of older adults relying on public assistance is negatively related only to women's DFLE. These results suggest that narrowing socioeconomic disparities may contribute to the health of Japanese elders. Reducing regional health disparities therefore requires policy makers to take into account the broader socioeconomic conditions of each prefecture.

Active social participation and mortality risk among older people in Japan: results from a nationally representative sample.

A large literature suggests that active social participation contributes to the well-being of older people. Japan provides a compelling context to test this hypothesis due to its rapidly growing elderly population and the phenomenal health of the population. Using the Nihon University Japanese Longitudinal Study of Aging, this study examines how social participation, measured by group membership, is related to the risk of overall mortality among Japanese elders aged 65 and older. Results from Cox proportional hazards models show that group affiliation confers advantages against mortality risk, even after controlling for sociodemographic characteristics, physical health measures, and family relationship variables. In particular, activities geared more toward self-development, such as postretirement employment and lifelong learning, are strongly associated with lower levels of mortality. Findings suggest that continued social participation at advanced ages produces positive health consequences, highlighting the importance of active aging in achieving successful aging in the Japanese context.

Gender gaps--Life expectancy and proportion of life in poor health.

BACKGROUND: The literature suggests that women report worse health but live longer than men--a phenomenon known as the gender paradox in health and mortality. Although studies examining the paradox abound, relatively little is known about mechanisms underlying the gap. DATA AND METHODS: With data on healthy life expectancy from the Global Burden of Disease Study 2010, this article analyses the relationship between length of life and health among men and women in 45 more-developed countries. The proportion of life spent in poor health is used as an indicator of health. This approach accounts for gender differences in longevity and illustrates the female health disadvantage pattern more clearly. RESULTS: Life expectancy at birth and the proportion of life in poor health are closely related for both genders. Furthermore, the larger the female excess in longevity, the larger the female excess in the proportion of life in poor health. INTERPRETATION: By focusing on the proportion of life in poor health, this analysis suggests that women's longevity advantage translates into a health disadvantages relative to men. The results indicate that women suffer from poor health not in spite of living longer, but because they live longer.

An analysis of the impact of cell phone use on depressive symptoms among Japanese elders.

BACKGROUND: There has been increasing interest in the impact of information and communication technologies, such as the computer and Internet, on physical and mental health status, but relatively little is known about the health effects of using cell phones. OBJECTIVE: This study investigates how cell phone usage is associated with levels of depressive symptoms among Japanese men and women aged 65 years and older. We focus on social relationships, particularly intergenerational relationships between older parents and adult children, as a possible mediator in the association of cell phone use with late-life depressive symptoms. We therefore hypothesize that using cell phones contributes to the psychological well-being of older adults primarily through encouraging social relationships. METHODS: We used 4 waves of data from the Nihon University Japanese Longitudinal Study of Aging (2001-2009) to analyze the impact of cell phone use on depressive symptoms. RESULTS are based on ordinary least squares regression analyses. RESULTS: Although the use of cell phones was related to lower levels of depressive symptoms among elderly Japanese people, controlling for sociodemographic characteristics and physical health conditions wiped out the effects for men. In contrast, the protective effects of using cell phones persisted among women, even net of all controls. Moreover, the impact of using cell phones was not explained by filial relationship measures, suggesting that cell phone use influences the mental health of older women independently of social engagement. CONCLUSIONS: Among the many advantages brought about by recent technological developments, cell phones appear to be an important contributor to the psychological well-being of Japanese elders. Researchers and policy makers should prioritize access to new technologies for older adults.

Gender differences in alcohol choice among Russians: evidence from a quantitative study.

AIMS: Qualitative studies find that men and women in Russia have different preferences for alcoholic beverages, but quantitative evidence for gender differences in beverage type choice remains scarce. The purpose of this article is to test numerically whether and to what extent men and women in Russia differ in terms of preferences for type of drink, such as vodka, wine and beer. METHODS: Results are based on multinomial logistic regression and ordinary least squares regression analyses of the Russian Longitudinal Monitoring Survey-Higher School of Economics 2008 data. RESULTS: We observed significant gender differences in preferences for alcoholic beverages. Men have strong preferences for vodka, and they drink it in much larger amounts in comparison with women. Women are more likely to either refrain from drinking or drink mild types of alcoholic beverages, such as wine and beer. Gender differences remain statistically significant even when sociodemographic factors are well accounted for. CONCLUSIONS: The present study confirms the previous research findings about gender differences in drinking practices among Russians. Our results provide quantitative evidence of the pronounced differences in beverage types consumed by men and women.