Asunto(s)
Carcinoma Basocelular/terapia , Carcinoma de Células Escamosas/terapia , Melanoma/terapia , Aceptación de la Atención de Salud , Neoplasias Cutáneas/terapia , Tiempo de Tratamiento , Anciano , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Japón , Masculino , Persona de Mediana Edad , Factores SexualesRESUMEN
Hidradenoma papilliferum (HP) is a benign adnexal neoplasm which preferentially develops in the anogenital region of women. Although the origin of HP was previously thought to be an apocrine sweat gland, recent studies have suggested that it may derive from the anogenital mammary-like gland (MLG). In this paper, we present a 43-year-old Japanese woman with hidradenoma papilliferum of the vulva. The lesion developed 7 years prior to her visit, and clinically appeared as a skin-colored cystic nodule. Histopathological examination revealed that the neoplasm was formed by the tubular structures consisting of two types of pleomorphic cells, columnar cells in the luminal layer and cuboidal cells in the basal layer. Further, the surgical specimen contained a wide, divergent, lobular ductal structure located in the vicinity of the neoplastic lesion, which was consistent with MLG.
Asunto(s)
Acrospiroma/patología , Neoplasias de las Glándulas Sudoríparas/patología , Neoplasias de la Vulva/patología , Acrospiroma/metabolismo , Adulto , Canal Anal/patología , Femenino , Genitales Femeninos/patología , Humanos , Receptores de Estrógenos/metabolismo , Receptores de Progesterona/metabolismo , Neoplasias de las Glándulas Sudoríparas/metabolismo , Neoplasias de la Vulva/metabolismoAsunto(s)
Carcinoma de Células Transicionales/patología , Enfermedad de Paget Extramamaria/patología , Neoplasias de la Vejiga Urinaria/patología , Neoplasias de la Vulva/patología , Carcinoma de Células Transicionales/secundario , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Persona de Mediana Edad , Neoplasias de la Vulva/secundarioAsunto(s)
Autoantígenos/inmunología , Moléculas de Adhesión Celular/inmunología , Colágenos no Fibrilares/inmunología , Penfigoide Benigno de la Membrana Mucosa/inmunología , Penfigoide Ampolloso/inmunología , Anciano de 80 o más Años , Antiinflamatorios/uso terapéutico , Autoanticuerpos/análisis , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Inmunoglobulina G/análisis , Masculino , Penfigoide Benigno de la Membrana Mucosa/complicaciones , Penfigoide Benigno de la Membrana Mucosa/tratamiento farmacológico , Penfigoide Ampolloso/complicaciones , Penfigoide Ampolloso/tratamiento farmacológico , Prednisolona/uso terapéutico , Kalinina , Colágeno Tipo XVIIRESUMEN
BACKGROUND: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in diagnosing and treating EPC. The aim of this study is to report the clinical and pathological features of EPC in order to contribute to the body of information currently available on the subject. PATIENTS AND METHODS: From 2003 to 2013, 8 Japanese patients were diagnosed with EPC at the Department of Dermatology in the Hachioji Medical Center of Tokyo Medical University. Patient data, including clinical manifestations, histopathological findings, immunohistochemical results, treatment method, and clinical course were collected and documented. RESULTS: The mean age of the patients (6 males and 2 females) was 72.6 years. The duration of the lesions ranged from 4 months to 5 years (mean: 3.5 years). All of the lesions clinically presented with erosive reddish nodules (mean size: 39.0 mm). Initial CT imaging revealed that 1 case had multiple distant metastases. Surgical resection was performed for all primary lesions and follow-up observations were available in all cases (mean: 10.9 months). One case with distal metastases underwent both radiation therapy and chemotherapy, but nevertheless succumbed to the disease. CONCLUSION: The EPC cases in our department presented a versatile clinical appearance and characteristic histopathological features.