Cardiovascular risk factor reduction by community health workers in rural India: A cluster randomized trial.

BACKGROUND: There is a need to identify and test low-cost approaches for cardiovascular disease (CVD) risk reduction that can enable health systems to achieve such a strategy. OBJECTIVE: Community health workers (CHWs) are an integral part of health-care delivery system in lower income countries. Our aim was to assess impact of CHW based interventions in reducing CVD risk factors in rural households in India. METHODS: We performed an open-label cluster-randomized trial in 28 villages in 3 states of India with the household as a unit of randomization. Households with individuals at intermediate to high CVD risk were randomized to intervention and control groups. In the intervention group, trained CHWs delivered risk-reduction advice and monitored risk factors during 6 household visits over 12 months. Households in the non-intervention group received usual care. Primary outcomes were a reduction in systolic BP (SBP) and adherence to prescribed BP lowering drugs. RESULTS: We randomized 2312 households (3261 participants at intermediate or high risk) to intervention (1172 households) and control (1140 households). At baseline prevalence of tobacco use (48.5%) and hypertension (34.7%) were high. At 12 months, there was significant decline in SBP (mmHg) from baseline in both groups- controls 130.3 ±â€¯21 to 128.3 ±â€¯15; intervention 130.3 ±â€¯21 to 127.6 ±â€¯15 (P < .01 for before and after comparison) but there was no difference between the 2 groups at 12 months (P = .18). Adherence to antihypertensive drugs was greater in intervention vs control households (74.9% vs 61.4%, P = .001). CONCLUSION: A 12-month CHW-led intervention at household level improved adherence to prescribed drugs, but did not impact SBP. To be more impactful, a more comprehensive solution that addresses escalation and access to useful therapies is needed.

"DIABETIC TAX" - Cost of Care among Persons with Type 2 Diabetes Mellitus in an Urban Underprivileged Area of Bengaluru.

BACKGROUND: Diabetes mellitus drains a significant percent of the health budget by cost toward direct diabetes care and diabetes-related disabilities. OBJECTIVES: The aim of the study is to assess the annual costs incurred by patients with type 2 diabetes mellitus. METHODOLOGY: This cross-sectional study was undertaken among 153 diabetic people in an urban underprivileged area of Bengaluru from January 2013 to January 2014. This was a cost of illness study done from the patient's perspective using a structured interview schedule. RESULTS: A diabetic person in an urban underprivileged community in Bengaluru spends 11,489.38 ± 28,341.77 annually for diabetic care. Direct and indirect costs accounted for 95% and 5% of costs. Majority were spent on admission (45.1%), followed by drugs (21.8%), investigations (5.6%), and consultations (4.5%). Nonmedical costs such as food and transport accounted for 18% of the costs. About 50% of them had delayed treatment due to financial constraints. Nearly 25% of patient's income and 10.7% of the family income were spent for diabetic care. Higher education, income, duration of disease, hospital admission, type of treatment, and place of treatment were found to be associated with costs. CONCLUSION: Estimates of cost will help conceptualize strategies to deal with the situation at local, regional, and national level.

Adherence to prescribed medications for chronic illnesses among older adults in a rural community, Karnataka, India.

AIM: To assess adherence to prescribed medications for chronic illnesses and to identify factors associated with it among rural older adults. METHODS: A cross-sectional study was carried out from September to November 2011 in three subcenters in Lakkur PHC, Kolar District, India. All older adults were listed, and those suffering from chronic non-communicable diseases were included in the study. A structured interview schedule comprising of 48 items was used to measure adherence, and to identify factors associated with adherence in the domains of socioeconomic status, therapy, health systems, patient behavior and physical factors. RESULTS: Of the 184 older adults included in the study, 63.6% were fully adherent to their medication. Non-adherence to medication showed a statistically significant relationship with the absence of a medical store within their village, non-availability of drugs at the nearest medical store, inability to understand the doctor's language, failure to explain the consequences of not taking medicines by the healthcare provider, self-alteration of medicine dosage, fear that medicines will lead to the development of dependence to medicines and difficulty in swallowing. Those who led busy lives, those who had been prescribed three or more types of medicines prescribed per day, those who required special skills to take medicines (injections, inhalers), those who had made adjustments to their usual lifestyle to take medicines and those who had knowledge that medicines need to be taken lifelong were more likely to be adherent to their medications. Four factors, namely, the doctor explaining the consequences of not taking medicines, altering the dosage of the medicines by the patients themselves, the number of medicines prescribed per day and having the knowledge that medicines need to be taken lifelong, were critical determinants of adherence to medications. Geriatr Gerontol Int 2016; 16: 1339-1345.

Challenges in conducting community-based trials of primary prevention of cardiovascular diseases in resource-constrained rural settings.

Cardiovascular diseases account for almost half of all deaths from noncommunicable diseases, and almost 80% of these deaths occur in low- and middle-income countries such as India. The PrePAre (Primary pREvention strategies at the community level to Promote treatment Adherence to pREvent cardiovascular disease) trial was a primary prevention trial of community health workers aimed at improving adherence to prescribed pharmacological and nonpharmacological therapies in cardiovascular diseases. It was conducted at three geographically, culturally and linguistically diverse sites across India, comprising 28 villages and 5699 households. Planning and implementing large-scale community-based trials is filled with numerous challenges that must be tackled, while keeping in mind the local community dynamics. Some of the challenges are especially pronounced when the focus of the activities is on promoting health in communities where treating disease is considered a priority rather than maintaining health. This report examines the challenges that were encountered while performing the different phases of the trial, along with the solutions and strategies used to tackle those difficulties. We must strive to find feasible and cost-effective solutions to these challenges and thereby develop targeted strategies for primary prevention of cardiovascular diseases in resource-constrained rural settings.

Rationale and design of the Primary pREvention strategies at the community level to Promote Adherence of treatments to pREvent cardiovascular diseases trial number (CTRI/2012/09/002981).

INTRODUCTION: Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality in low-income countries including India. There is a need for effective, low-cost methods to prevent CVDs in rural India. One strategy is to identify and implement interventions at high-risk individuals using community health workers (CHWs). There is a paucity of CHW-based CVD intervention trials from low-income countries. METHODS: We designed a multicenter, household-level, cluster-randomized trial with 1:1 allocation to intervention and control arms. The CHWs undertook a door-to-door survey and screened 5,699 households in 28 villages from 3 rural regions in India to identify at-risk households. The households were defined as those with ≥1 individual aged ≥35 years and at moderate or high risk for CVD based on the non-laboratory-based National Health and Nutrition Examination Survey score. All at-risk individuals were invited to attend a physician-led village clinic that provided a CVD risk reduction prescription and education about target risk factor levels for CVD control. All households in which at least 1 member at moderate to high risk for CVD had received a risk reduction prescription were eligible for randomization. Households randomized to the CHW-based intervention will receive 1 household visit by a CHW every 2 months, for 12 months. During these visits, CHWs will measure blood pressure, ascertain and reinforce adherence to prescribed therapies, and modify therapy to meet targets. Households randomized to the control arm do not receive CHW visits. At 12 months after randomization, we will evaluate 2 primary outcomes of systolic blood pressure and adherence to antihypertensive drugs and secondary outcomes of INTERHEART risk score, body mass index, and waist-to-hip ratios. At 18 to 24 months after randomization and 6 to 12 months after the last intervention, we will record these outcomes to evaluate sustainability of intervention. RESULTS: Community health workers screened a total of 5,033 households that included 9,248 individuals and identified 2,571 households with 3,784 at-risk individuals. We randomized 2,438 households (1,219 to intervention and 1,219 to control groups). CONCLUSION: Our large trial of CHWs in rural India will provide important information regarding a promising approach to primary prevention of CVDs.

Childhood blindness in a rural population of southern India: prevalence and etiology.

PURPOSE: To determine the prevalence and etiology of childhood blindness in a rural population in southern India through a population based study. METHODS: A cross sectional, house-to-house survey to screen for childhood blindness included 14,423 children < 16 years. Blindness was defined as best corrected visual acuity < 3/60 in the better eye. The first stage of screening for blindness was done by interns under supervision of ophthalmology residents. Senior residents examined the referred cases from the first stage. Those detected to be blind were brought to a tertiary care hospital for detailed examination. RESULTS: Fifty-four children were referred after first stage of screening of 13,241 children. Of these 14 were bilaterally blind giving a prevalence of 1.06/1000 (95% confidence interval (CI), 0.50 to 1.61); 6 (42.9%) had lens and related complications, 4 (28.6%) had globe anomalies (2 Microphthalmos and 2 Anophthalmos), 2 (14.3%) had retinal dystrophy and 1 (7.1%) each of glaucoma and optic atrophy. Among the parents of blind children, 71.4% (p = 0.002) had consanguineous marriage (83.3% in cataract blind children). CONCLUSIONS: More than half of the blindness detected was potentially avoidable. Genetic counseling, early identification and access to tertiary care would reduce the burden of childhood blindness in the local community.