RESUMEN
The gerbil Meriones unguiculatus, infected with three species of nematodes, each located in a separate part of the gastrointestinal tract, provided a reliable laboratory assay for the evaluation of broad-spectrum anthelmintic activity. Gerbils harbouring 6-day-old infections of Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis were given selected broad-spectrum anthelmintics by gavage. Three benzimidazoles, thiabendazole, oxfendazole and albendazole, a tetrahydropyrimidine, morantel, an imidazothiazole, levamisole hydrochloride, a macrocyclic lactone, ivermectin and an experimental natural product, paraherquamide, were active against all three nematodes at various dosages. Trichostrongylus colubriformis was most sensitive to levamisole hydrochloride, morantel, thiabendazole and paraherquamide whereas ivermectin, oxfendazole and albendazole were more effective against H. contortus. All compounds were active against the caecal nematode T. sigmodontis although it was less sensitive than T. colubriformis. Haemonchus contortus was more sensitive than T. sigmodontis to all anthelmintics tested except thiabendazole.
Asunto(s)
Antihelmínticos/uso terapéutico , Gerbillinae/parasitología , Trichostrongyloidea/efectos de los fármacos , Tricostrongiloidiasis/tratamiento farmacológico , Albendazol/uso terapéutico , Animales , Bencimidazoles/uso terapéutico , Femenino , Hemoncosis/tratamiento farmacológico , Haemonchus/efectos de los fármacos , Indolizinas/uso terapéutico , Ivermectina , Levamisol/uso terapéutico , Masculino , Morantel/uso terapéutico , Pruebas de Sensibilidad Parasitaria , Compuestos de Espiro/uso terapéutico , Tiabendazol/uso terapéutico , Tricostrongiloidiasis/veterinaria , Trichostrongylus/efectos de los fármacosRESUMEN
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-beta-D-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced the kidney fungal burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.
Asunto(s)
Antifúngicos/uso terapéutico , Aspergillus flavus/efectos de los fármacos , Aspergillus nidulans/efectos de los fármacos , Aspergillus/efectos de los fármacos , Péptidos Cíclicos/uso terapéutico , Animales , Caspofungina , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Equinocandinas , Femenino , Lipopéptidos , Ratones , Ratones Endogámicos DBA , Pruebas de Sensibilidad Microbiana , Análisis de Supervivencia , Factores de Tiempo , Resultado del TratamientoRESUMEN
The ability of an in vivo anticoccidial assay to identify potential feed-through insecticides was demonstrated using first-instar Lucilia sericata on droppings from chicks fed medicated diets. Cyromazine, a commercially available feed-through insect growth regulator, ivermectin, diflubenzuron, fipronil, permethrin, and 2 experimental compounds were effective in varying degrees in killing L. sericata larvae. Eleven coccidiostats were effective against the protozoan parasites (Eimeria spp.) at commercially used levels, whereas they were ineffective against Lucilia larvae.