RESUMEN
We investigate simple three-dimensionally crossed wires carrying electric currents which generate chaotic magnetic-field lines (CMFLs). As such wire systems, cross-ring and perturbed parallel-ring wires are studied, since topologically equivalent configurations to these systems can often be found in contemporary electric and integrated circuits. For realistic fundamental wire configurations, the conditions for wire dimensions (size) and current values to generate CMFLs are numerically explored under the presence of the weak but inevitable geomagnetic field. As a result, it is concluded that CMFLs can exist everywhere; i.e., they are ubiquitous in the modern technological world.
RESUMEN
[4-3,5-Bis(trimethylsilyl)benzamido] benzoic acido] (TAC-101), which exhibits an anti-tumor effect, can bind to retinoic acid receptors (RARs). It has retinoid-like properties, such as chemopreventive action against cancer cells. The up-regulation of connexin (Cx) expression by retinoids is well known in various epithelial cells. In this study, we investigated whether TAC-101 up-regulates gap junctional intercellular communication (GJIC) in renal epithelial cells exposed to the renal carcinogens. Madin Darby canine kidney (MDCK) cells were incubated with TAC-101 for 3 days, then briefly exposed to renal carcinogens potassium bromate (KBrO3) or dimethylnitrosamine (DMN). TAC-101 increased the expression of connexin 43 protein without affecting Cx43 phosphorylation and prevented inadequate Cx43 localisation caused by KBrO3 or DMN. Consequently, TAC-101 prevented the disruption of GJIC in MDCK cells. These data suggested that TAC-101 enhanced GJIC by up-regulating Cx43 expression and that TAC-101 might be useful for the prevention of renal cell carcinoma.
Asunto(s)
Anticarcinógenos/farmacología , Benzoatos/farmacología , Carcinógenos/farmacología , Comunicación Celular/efectos de los fármacos , Uniones Comunicantes/efectos de los fármacos , Riñón/citología , Riñón/efectos de los fármacos , Compuestos de Trimetilsililo/farmacología , Animales , Western Blotting , Bromuros/farmacología , Comunicación Celular/fisiología , División Celular/efectos de los fármacos , Permeabilidad de la Membrana Celular/efectos de los fármacos , Conexina 43/metabolismo , Dimetilnitrosamina/farmacología , Perros , Interacciones Farmacológicas , Células Epiteliales/citología , Células Epiteliales/efectos de los fármacos , Células Epiteliales/metabolismo , Técnica del Anticuerpo Fluorescente , Uniones Comunicantes/metabolismo , Uniones Comunicantes/fisiología , Neoplasias Renales/inducido químicamente , Neoplasias Renales/prevención & control , Fosforilación , Compuestos de Potasio/farmacología , Regulación hacia Arriba/efectos de los fármacosRESUMEN
A 48-year-old man was admitted to our hospital for lumbago. Computerized tomographic (CT) scan, aortography and venacavography indicated a solid retroperitoneal tumor at the right renal hilus. The tumor was removed and right nephrectomy was conducted. Some of the tumor remained owing to strong adhesion to the inferior vena cava and lumbar spine. Histological diagnosis of the resected tumor was retroperitoneal xanthogranuloma. One year after surgery, the CT scan revealed a gradual decrease in size of the remaining retroperitoneal mass.
