1.
Zhongguo Zhong Yao Za Zhi
; 28(8): 754-6, 2003 Aug.
Artículo
en Chino
| MEDLINE
| ID: mdl-15015360
RESUMEN
OBJECTIVE: To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels. METHOD: The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique. RESULT: Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly. CONCLUSION: Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.