Probing Denaturation of Protein A via Surface-Enhanced Infrared Absorption Spectroscopy.

We apply surface-enhanced infrared absorption (SEIRA) spectroscopy to monitor the denaturation process of a surface-bound protein A monolayer. Our proposed platform relies on a plasmonic metasurface comprising different spatial subregions ("pixels") that are engineered to exhibit different resonances covering the infrared region of the electromagnetic spectrum that is matched to the vibrational modes of the Amide groups. Specifically, we are able to determine changes in the Amide I and Amide II vibration coupled modes, by comparing the SEIRA reflectance spectra pertaining to the native state and a denatured state induced by a pH variation. In particular, we observe some evident red-shifts in the principal Amide I mode and the Amide II vibration coupled modes (attributable to the breaking of hydrogen bonds), which result in insurmountable barriers for refolding. Thanks to the strong field localization, and consequent enhancement of the light-matter interactions, our proposed sensing platform can operate with extremely small amounts of an analyte, with an estimated detection limit of about 3 femtomoles of molecules.

Advanced DNA Detection via Multispectral Plasmonic Metasurfaces.

We propose and demonstrate a sensing platform based on plasmonic metasurfaces for the detection of very low concentrations of deoxyribo-nucleic acid (DNA) fragments. The platform relies on surface-enhanced infrared absorption spectroscopy, implemented via a multispectral metasurface. Specifically, different regions ("pixels") are engineered so as to separately cover the medium-infrared range of the electromagnetic spectrum extending from the functional-groups to the fingerprint region of a single analyte. In conjunction with a suitable bio-functionalization, this enables univocal and label-free recognition of specific molecules. For experimental validation, we fabricate a large-area gold metasurface on a silicon chip, and functionalize it with a recognition layer of peptide nucleic acid (PNA). Our experimental results indicate the possibility to detect complementary DNA fragments in concentrations as low as 50 fM, i.e., well below the value attained by standard methods, with additional advantages in terms of processing time, versatility and ease of implementation/operation.

Non-Hermitian doping of epsilon-near-zero media.

In solid-state physics, "doping" is a pivotal concept that allows controlling and engineering of the macroscopic electronic and optical properties of materials such as semiconductors by judiciously introducing small concentrations of impurities. Recently, this concept has been translated to two-dimensional photonic scenarios in connection with host media characterized by vanishingly small relative permittivity ("epsilon near zero"), showing that it is possible to obtain broadly tunable effective magnetic responses by introducing a single, nonmagnetic doping particle at an arbitrary position. So far, this phenomenon has been studied mostly for lossless configurations. In principle, the inevitable presence of material losses can be compensated via optical gain. However, taking inspiration from quantum (e.g., parity-time) symmetries that are eliciting growing attention in the emerging fields of non-Hermitian optics and photonics, this suggests considering more general gain-loss interactions. Here, we theoretically show that the photonic doping concept can be extended to non-Hermitian scenarios characterized by tailored distributions of gain and loss in either the doping particles or the host medium. In these scenarios, the effective permeability can be modeled as a complex-valued quantity (with the imaginary part accounting for the gain or loss), which can be tailored over broad regions of the complex plane. This enables a variety of unconventional optical responses and waveguiding mechanisms, which can be, in principle, reconfigured by varying the optical gain (e.g., via optical pumping). We envision several possible applications of this concept, including reconfigurable nanophotonics platforms and optical sensing, which motivate further studies for their experimental validation.

Suboptimal Coding Metasurfaces for Terahertz Diffuse Scattering.

Coding metasurfaces, composed of only two types of elements arranged according to a binary code, are attracting a steadily increasing interest in many application scenarios. In this study, we apply this concept to attain diffuse scattering at THz frequencies. Building up on previously derived theoretical results, we carry out a suboptimal metasurface design based on a simple, deterministic and computationally inexpensive algorithm that can be applied to arbitrarily large structures. For experimental validation, we fabricate and characterize three prototypes working at 1 THz, which, in accordance with numerical predictions, exhibit significant reductions of the radar cross-section, with reasonably good frequency and angular stability. Besides the radar-signature control, our results may also find potentially interesting applications to diffusive imaging, computational imaging, and (scaled to optical wavelengths) photovoltaics.

Waveguide Characterization of S-Band Microwave Mantle Cloaks for Dielectric and Conducting Objects.

We present the experimental characterization of mantle cloaks designed so as to minimize the electromagnetic scattering of moderately-sized dielectric and conducting cylinders at S-band microwave frequencies. Our experimental setup is based on a parallel-plate waveguide system, which emulates a two-dimensional plane-wave scattering scenario, and allows the collection of near-field maps as well as more quantitative assessments in terms of global scattering observables (e.g., total scattering width). Our results, in fairly good agreement with full-wave numerical simulations, provide a further illustration of the mantle- cloak mechanism, including its frequency-sensitivity, and confirm its effectiveness both in restoring the near-field impinging wavefront around the scatterer, and in significantly reducing the overall scattering.

Opto-acoustic behavior of coated fiber Bragg gratings.

In this paper, we present the study of the acousto-optic behavior of underwater-acoustic sensors constituted by fiber Bragg gratings (FBGs) coated by ring-shaped overlays. Via full-wave numerical simulations, we study the complex opto-acousto-mechanical interaction among an incident acoustic wave traveling in water, the optical fiber surrounded by the ring shaped coating, and the FBG inscribed the fiber, focusing on the frequency range 0.5-30 kHz of interest for SONAR applications. Our results fully characterize the mechanical behavior of an acoustically driven coated FBG, and highlight the key role played by the coating in enhancing significantly its sensitivity by comparison with a standard uncoated configuration. Furthermore, the hydrophone sensitivity spectrum exhibits characteristic resonances, which strongly improve the sensitivity with respect to its background (i.e., away from resonances) level. Via a three-dimensional modal analysis, we verify that the composite cylindrical structure of the sensor acts as an acoustic resonator tuned at the frequencies of its longitudinal vibration modes. In order to evaluate the sensor performance, we also carry out a comprehensive parametric analysis by varying the geometrical and mechanical properties of the coating, whose results also provide a useful design tool for performance optimization and/or tailoring for specific SONAR applications. Finally, a preliminary validation of the proposed numerical analysis has been carried out through experimental data obtained using polymeric coated FBGs sensors revealing a good agreement and prediction capability.