Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention.

This detailed review disclosed the NF-κB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms involving inhibitory proteins like IκB and p100 within the NF-κB signaling cascade. Disruption of the pathway is important in uncontrolled inflammation and immune disorders. This study extensively describes the role connections of canonical and non-canonical signaling pathways of NF-κB with inflammatory and cellular responses. SIRT1 belongs to the class III histone deacetylase, via RelA/p65 deacetylation, it regulates the activity of NF-κB, closely linked with the NAD+/NADH cellular ratio, influencing stress responses, aging processes, gene regulation, and metabolic pathways. This detailed study reveals SIRT1 as a crucial avenue for uncovering the role of imbalanced NF-κB in diabetes, obesity, and atherosclerosis. This study provides valuable knowledge about the therapeutic targets of inflammatory disorders.

Ethnobotanical Significance, Phytopharmacology, and Toxicological Profile of Limonia acidissima L. (Rutaceae): A Review.

Medicinal plants play a crucial role in traditional medicine, where they are extensively employed by traditional physicians for treating a wide array of ailments. Limonia acidissima (Linn), commonly known as the Wood apple and belonging to the Rutaceae family, is widely cultivated in countries, such as Pakistan, India, and Sri Lanka. The various parts of Limonia acidissima, including its roots, leaves, fruits, stem, and even the whole plant, have been traditionally used in the treatment of numerous conditions, such as constipation, diarrhea, dysentery, skin diseases, asthma, astringent, diabetes, jaundice, and dyspepsia and act as diuretic agents, cardiotonic, cardiac stimulant, and hepato-protectant. Extensive research has revealed that Limonia acidissima possesses a rich chemical composition, including quinones, lignans, flavonoids, sterols, coumarins, alkaloids, triterpenoids, phenolic acids, and volatile oils, present in its stem, leaves, fruits, stem bark, and roots. These chemical constituents contribute to its diverse therapeutic properties. In recent years, numerous studies have explored the ethanopharmacological properties of Limonia acidissima extracts, highlighting their anticancer, antidiabetic, anti-diarrheal, antimicrobial, antiulcer, wound healing, antioxidant, hepatoprotective, antibacterial, antifungal, larvicidal, neuroprotective, antispermatogenic, antihistaminic, diuretic, and adsorbent activities. This comprehensive review focuses on the traditional uses, biological activities, and phytoconstituents isolated from different parts of Limonia acidissima Linn. The gathered information provides valuable insights into the therapeutic potential of this plant, serving as a foundation for further research and the development of novel pharmaceuticals. The integration of traditional knowledge with scientific evidence enhances the understanding of the medicinal properties of Limonia acidissima, fostering its utilization in modern medicine and healthcare systems.

ß-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats.

Alzheimer's disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of ß-amyloid (Aß) peptide in the rat brain including the study of neuroinflammation, neurodegeneration, and alterations in peripheral immune responses (PIR). The neuroinflammation brought on by Aß1-42 and is unknown to influence PIR. Animal models were prepared, after 28 days, control, sham, and treated rats were anaesthetized and inflammatory markers of hippocampus and serum levels (reactive oxygen species, nitrite, tumor necrosis factor-α, and interleukin-1ß), and some markers of PIR (splenic mononuclear cells or MNC, cytotoxicity and phagocytic index of the white blood cells leukocyte adhesion inhibition index or LAI), as well as polymorphonuclear cells of the spleen, were assessed. In addition to changes in peripheral immune responses, the present study found that AD rats had higher blood levels of inflammatory markers. Based on the study, the immune system irregularities observed in AD rats in the peripheral regions might be connected to neuroinflammation, which is facilitated by a compromised blood-brain barrier. Hence, it is viable to propose that the neuroinflammatory condition in rats with Aß-induced AD could modify immune responses in the peripheral areas with significantly higher levels of inflammatory cytokines markers in the hippocampal tissue in Aß-injected AD rats.

An efficient MPPT techniques for inter-harmonic reduction in grid connected hybrid wind and solar energy systems.

In this work, the operation of photovoltaic system, wind turbine driven doubly fed induction generator along with battery has been observed. Also, a searching space minimization-based artificial bee colony scheme is developed for tracking the maximum power in a doubly fed induction generator-based system. To track maximum power in solar systems, an improved adaptive reference voltage approach has been presented. Several conventional and optimization-based techniques are used by DFIG and photovoltaic systems to get around the non-linearity features in the output parameters. Regarding DFIG, the artificial bee colony method based on searching space minimization can be used to solve the shortcomings of the perturb and observe algorithm. Because of its weather-sensitive nature, it can withstand sudden changes in wind speed. The suggested searching space minimization based artificial bee colony strategy uses a mechanism for determining the range of optimal rotor speed in order to track the maximum power point more quickly. The maximum power point tracking performance of the adaptive reference voltage technique is superior to that of current perturb and observed-based systems. However, a huge processing memory is required in order to track the maximum possible power point. This paper proposes an enhanced maximum power point tracking technique based on adaptive reference voltage that does not require a memory unit. Additionally, despite sudden changes in irradiation conditions, improved adaptive reference voltage can drift-free and reliably monitor the maximum power point. The new adaptive reference voltage technique uses temperature and radiation sensors to identify the region nearest to the maximum power point. This helps the system respond more quickly. The proposed system with searching space minimization based artificial bee colony and improved adaptive reference voltage schemes displays lower inter-harmonic content in grid current compared to perturb and observe scheme. The proposed scheme has been implemented in MATLAB & simulink atmosphere and OPAL-RT displayed satisfactory results.

Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry Estimation of Quercetin-Loaded Nanoemulsion in Rabbit Plasma: In Vivo-In Silico Pharmacokinetic Analysis Using GastroPlus.

In the present study, we developed and validated a rapid, specific, sensitive, and reproducible liquid chromatography-electrospray ionization tandem mass spectrometry method for quantifying quercetin (QT) in rabbit plasma using hydrochlorothiazide as the internal standard. Animals were orally administered with optimized QT-loaded nanoemulsion (QTNE) and QT suspension (QTS), equivalent to 30 mg/kg, to the test and control group, respectively. The blood samples were collected at pre-determined time points up to 48 h. The linearity range was from 5 to 5000 ng mL-1 with R 2 = 0.995. Further, we analyzed the various pharmacokinetic parameters and established the in vitro-in vivo correlation (IVIVC) of QTNE using GastroPlus software. The method was successfully developed and validated, and when applied for the determination of QT in rabbit plasma, it exhibited an increase in C max from 122.56 ng mL-1 (QTS) to 286.51 ng mL-1 (QTNE) (2.34-fold) and AUC0-48 from 976 ng h mL-1 (QTS) to 4249 ng h mL-1 (QTNE) (4.35-fold), indicating improved oral bioavailability QT when administered as QTNE. Statistical analysis revealed that the Loo-Riegelman method (two-compartmental method) best fitted the deconvolution approach (R 2 = 0.998, SEP = 4.537, MAE = 2.759, and AIC = 42.38) for establishing the IVIVC. In conclusion, the established bioanalytical method and IVIVC studies revealed that QTNE is a potential carrier for the effective delivery of QT with enhanced oral bioavailability.

Prevalence, Patterns, and Predictors of Physical Inactivity in an Urban Population of India.

Physical inactivity (PI) is a risk factor for mortality and morbidity. PI and its predictors among the urban population in Bhubaneswar, India, were unknown. Finding out the contribution of PI as a cause of existing noncommunicable diseases (NCD) is difficult without following up with a cohort. The study was hence done to find out the prevalence, patterns, and predictors of physical inactivity in an urban population, and simultaneously investigate its causal relationship with NCD from this cross-sectional study. Cluster random sampling was used with a sample size of 1203 with a design effect of three. Socio-demographic, health profile, physical activity levels, and stage of change for physical activity behavior were collected. Logistic regression and marginal structural model analysis (by inverse probability of treatment weighting {IPTW} using a generalized estimating equation {GEE} to investigate the relationship between physical activity and prevalence of NCDs) were done using IBM SPSS v20 software (Armonk, NY: IBM Corp.). Statistical significance was tested at p=0.05. A total of 1221 subjects participated. The mean age was 35.25 years and 71.9% were physically inactive. General caste, presence of NCD, and being in a static stage of change influenced physical activity positively. PI was found to be a risk factor for NCD with 1.54 times higher odds in this population. The study concluded that the prevalence of physical activity was low and PI was a causative factor for NCD.

Connecting the dots between inflammatory cascades of obesity and COVID-19 in light of mortal consequences-a review.

Obesity is a term that has recently been referred to describe a condition in which a person has become a diseased vessel. Obesity's internal pathology is too mysterious as it has a close resemblance with fatal diseases pathology. Obesity and coronavirus disease 2019 (COVID-19) are simultaneous epidemics declared by many organizations after observing their rampage in the recent world. Oxidative stress, cytokine storm, interleukin, and their contribution to the internal adipocyte environment implicated in the cascades of inflammatory pathology are portrayed here. Major determinants like angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin-aldosterone system (RAAS) axis are highly sensitive molecular factors. Data from various countries suggested a clinical overview of how greater body mass index (BMI) is related to greater COVID-19 risk. It also gives insight into how obese individuals are obligately getting admitted and combating COVID-19 in intensive care unit including children less than 13 years of age under ultimate therapeutic options. There are numerous studies currently taking place for finding a cure for obesity which are mainly focused on natural resources and novel therapies like photobiomodulation (PBM) consisting of laser treatment, infrared treatment, etc. as current pharmacological treatments are reported to have fatal adverse effects. Finally, it is discussed how attenuating obesity will be a solution for future combat strategy. This review gives light on the areas of coagulation, inflammatory parameters, cardiometabolic complications, endothelial dysfunctions, immunological infirmity due to COVID-19 in obese individuals. A conceptual outline about correlation between the inflammatory pathophysiological steps triggering the aggravation of fatal consequences has been drawn in this review.

Prevalence, Patterns, and Predictors of Yoga Practice Among Adults in an Urban Population in Eastern India.

The objective of this study was to determine the prevalence and predictors of yoga practice. This cross-sectional study was conducted as a part of a larger study that included yoga as a form of physical activity. Data were collected during April and August 2019 from the adult urban population of Bhubaneswar, India. This study was conducted using a cluster random sampling method. A representative sample (n = 1,203) of adults aged 18-59 years, irrespective of gender, was interviewed using a questionnaire adapted from the 2012 U.S. National Health Interview Survey, with the Epicollect5 handheld data-collection tool. Predictors of yoga practice were explored using multivariable logistic regression. The mean age of the participants was 35.19 ± 10.67 years, with 55.3% males. The majority were Hindu (93.62%) and belonged to the unre s e rved category (65.60%), people generally of higher relative socioeconomic status. The lifetime prevalence of yoga was 16.9%. Prevalence of any form of yoga (yoga, pranayama, or meditation), all forms of yoga (yoga, pranayama, and meditation), pranayama, and meditation was 17.0%, 10.7%, 14.3%, and 11.4%, respectively. After adjusting for confounders, female gender, Hindu religion, minimum of higher-secondary or graduate-level education, and having received advice from professionals for yoga practice had significantly higher odds of practicing yoga, and those of higher socioeconomic status had significantly lower odds of practicing yoga. We found a low prevalence of yoga. Sociodemographic characteristics like gender, religion, education, socioeconomic status, and other factors like learning yoga from professionals may be important predictors of continued yoga practice.

Non-communicable disease care and physical activity promotion in India: analysis of recent policies, guidelines and workplans.

Burden statements on non-communicable diseases (NCDs) across the globe suggest that they pose a constant threat to human development. There are two different types of NCD interventions: population-based interventions addressing NCD risk factors and individual-based interventions addressing NCDs in the primary care setting. Most of the individual-based interventions are based on NCD-care models, as opposed to population-based interventions targeting risk factors through independent vertical programmes. We explored the relevant Indian policy documents including the recent National Health Policy 2017, to get an overview of the Indian NCD-care model and to find out how physical activity (PA) promotion stands in the year 2019 in the current policy documents on NCDs. We conducted a review with two perspectives; first to capture the NCD-care models and second to document the PA promotion and its integration in the current NCD-care model specific to the Indian context. Indian NCD programme is an evolving healthcare programme with a definite NCD-care model, where the individual-based and population-based care are thoroughly linked. Despite having good NCD-care policy and methodical planning, PA promotion seems to be lacking in the policy perspective and currently physical inactivity as a risk factor is not considered seriously. The structure of the NCD-care model should be detailed and strengthened by incorporating lessons from other successful NCD models from across the globe. Indian NCD model must provide sufficient scope of interfacing individual care to that of population-based risk factor strategies like physical activity promotion.

Can Yoga Meet the Requirement of the Physical Activity Guideline of India? A Descriptive Review.

BACKGROUND: Physical inactivity is the fourth major risk factor for global mortality accounting for 6% of all deaths globally and it is a key risk factor for noncommunicable disease occurrences. About 54.4% of Indians are physically inactive and <10% engage in recreational activities. On the one hand, India is spreading the message of Yoga, as a form of physical activity (PA) to the whole world. On the other hand, until now, the Physical Activity Guideline (PAG) in India is not yet fully developed. Therefore, we conducted a descriptive review of the rationality of yoga as one of the PA tools with two hypotheses - Does yoga qualify as a PA tool? Moreover, can yoga help to meet the requirement of Indian PAG?. METHODS: An in-depth literature review was carried out using databases such as PubMed, ScopeMed, Google Scholar, and Cochrane Library. All the published articles, government reports and policy documents, which met inclusion criteria with specific reference to yoga and energy expenditure, were gathered. RESULTS: The search strategy yielded 838 articles, of which 16 documents were considered for review. The review included 7 policy documents and/or studies that discussed PAGs/policy/strategy globally and 9 research studies targeted toward the energy expenditure and yoga. Huge variability was documented in the recommended PAGs globally and yoga found to be the moderate metabolic equivalents of tasks in the form of energy expenditure in this review. CONCLUSION: The compendium of physical activities should add a separate category for energy expenditure by yoga. This will help build-up newer exercise formats involving yogic physical activities to comply with the daily-recommended PA dose. In the national PA plan for India, yoga should get a prominent place. Further, in the Indian perspective, an exclusive PA plan is justified instead of a PA embedded within the national health programs in lieu of wider scope.