RESUMEN
A study was made on 8 eyes of 5 patients between 47 and 65 years of age with peripapillary pachychoroidopathy. They all presented with a serous detachment of the neuroepithelium or retinal pigment epithelium in the nasal macular region that extended to the optic disc, with an increase in choroidal thickness at that level. An analysis was made of the choroidal thickness using high penetration optical coherence tomography, as well as their outcome in a period between 12 and 48 months. Peripapillary pachychoroidopathy is a distinct variant of the pachychoroid disease spectrum. It must be distinguished from other disorders, such as inflammatory or neuro-ophthalmological conditions, that may manifest in the vicinity of the optic disc. When faced with a patient with suspected pachychoroidopathy, a specific study of the papillary area should be considered using high penetration optical coherence tomography.
RESUMEN
Ocular manifestations are observed in 25% of patients with Takayasu's arteritis. Its signs and symptoms can be very variable. The case is presented of a 41-year-old woman with progressive vision loss in her right eye secondary to ischaemic retinal arterial occlusion. After a systematic study, a protein purified derivative (PPD) skin test compatible with tuberculosis was found to be the only alteration. After ruling out other causes, and based on the initial suspicion of tuberculous retinal vasculitis, treatment was started with antimicrobial agents and systemic corticosteroids, without any therapeutic response. Eighteen months later, the patient developed acute kidney failure, secondary to right renal artery stenosis. The CT-angiography revealed a thickening of the aortic arch and its branches, and Takayasús arteritis was finally diagnosed. Therefore, emphasis is made on the importance of the ophthalmologist in the diagnosis of Takayasús arteritis, in which its ophthalmological manifestations can be an early sign of the disease.
Asunto(s)
Isquemia/etiología , Oclusión de la Arteria Retiniana/etiología , Arteria Retiniana , Arteritis de Takayasu/complicaciones , Adulto , Femenino , Humanos , Arteritis de Takayasu/diagnósticoRESUMEN
A 32 year-old man who presented with severe elevation of blood pressure after failure of kidney transplant. The patient had multiple serous retinal detachments, venous dilation, arteriolar narrowing, retinal haemorrhages, as well as optic disc oedema. Due to the impossibility of performing a fluorescein angiography, an angiotomography and en-face optical coherence tomography images were used to identify the vascular alterations in the retina, choroid, and choriocapillaris. Angiotomography and en face-optical coherence tomography mode images are very useful in cases where it is not possible to perform fluorescein angiography.
Asunto(s)
Hipertensión Maligna/complicaciones , Trasplante de Riñón/efectos adversos , Adulto , Inhibidores de la Angiogénesis/uso terapéutico , Bevacizumab/uso terapéutico , Coroides/irrigación sanguínea , Coroides/diagnóstico por imagen , Humanos , Riñón/lesiones , Edema Macular/tratamiento farmacológico , Edema Macular/etiología , Masculino , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Insuficiencia Renal/cirugía , Desprendimiento de Retina/diagnóstico por imagen , Desprendimiento de Retina/etiología , Hemorragia Retiniana/diagnóstico por imagen , Hemorragia Retiniana/etiología , Oclusión de la Vena Retiniana/diagnóstico por imagen , Oclusión de la Vena Retiniana/etiología , Tomografía de Coherencia Óptica , Insuficiencia del TratamientoRESUMEN
CASE REPORT: The case is presented of a 39-year-old woman with metastatic melanoma treated with dabrafenib and trametinib. She presented with a severe acute panuveitis with granulomatous anterior uveitis, vitritis, and multiple serous retinal detachments. Dabrafenib and trametinib were suspended, and treatment with a systemic and topical corticosteroid was started. A good response was obtained, with a recovery of visual acuity of 1.0 in both eyes within two weeks. DISCUSSION: Dabrafenib and trametinib can lead to severe uveitis. Treatment with corticosteroids and discontinuation of therapy with dabrafenib and trametinib led to an anatomical and functional improvement, and resolved the episode rapidly. Ophthalmologists must be aware of this toxicity, given the increasing use of those drugs.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Imidazoles/efectos adversos , Oximas/efectos adversos , Panuveítis/inducido químicamente , Piridonas/efectos adversos , Pirimidinonas/efectos adversos , Desprendimiento de Retina/inducido químicamente , Corticoesteroides/uso terapéutico , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Azetidinas/administración & dosificación , Azetidinas/efectos adversos , Sinergismo Farmacológico , Resultado Fatal , Femenino , Humanos , Imidazoles/administración & dosificación , Quinasas Quinasa Quinasa PAM/antagonistas & inhibidores , Melanoma/tratamiento farmacológico , Melanoma/secundario , Proteínas de Neoplasias/antagonistas & inhibidores , Oximas/administración & dosificación , Panuveítis/tratamiento farmacológico , Piperidinas/administración & dosificación , Piperidinas/efectos adversos , Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores , Piridonas/administración & dosificación , Pirimidinonas/administración & dosificación , Vemurafenib/administración & dosificaciónRESUMEN
CASE REPORT: The case is reported of a 61 year-old woman with Purtscher-like retinopathy associated with acute renal failure. Ophthalmic examination, fluorescein-angiography, and optical coherence tomography were consistent with Purtscher-like retinopathy. Ophthalmic symptoms and signs preceded renal failure. Pancreatitis and other systemic diseases were ruled out. The patient developed a neovascular glaucoma. DISCUSSION: Purtscher-like retinopathy rarely precedes the associated systemic illness. Early diagnosis based on ophthalmic symptoms may help in the recognition and treatment of the disease, and prevent later complications.
Asunto(s)
Lesión Renal Aguda/complicaciones , Ceguera/complicaciones , Enfermedades de la Retina/complicaciones , Femenino , Humanos , Persona de Mediana EdadRESUMEN
CASE REPORT: The case is presented of a 45 year-old man with a focal choroidal excavation associated with choroidal neovascularisation not included in the area of excavation. Clinical features were analysed using retinography, fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography. The patient was treated with 3 intravitreal injections of bevacizumab, with a good response. DISCUSSION: Focal choroidal excavation can be associated with choroidal neovascularization not included in the area of excavation. Multimodal imaging provides a complete description of clinical features, before and after treatment.
Asunto(s)
Enfermedades de la Coroides/complicaciones , Neovascularización Coroidal/complicaciones , Enfermedades de la Coroides/diagnóstico por imagen , Neovascularización Coroidal/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana EdadRESUMEN
CASE REPORT: The case is presented of 42 year-old woman with no significant medical history, with severe headaches, nausea and vomiting, hearing loss, and alteration of mental status with disorientation and confusion. Ophthalmic examination showed optic disc hyperaemia in right eye, and focal areas of arteriolar occlusion in both eyes. Audiometry demonstrated bilateral neurosensory hypoacusis. Magnetic Resonance Imaging showed multiple small round hyperintense lesions located in the splenium, corpus callosum, basal ganglia, and white matter. DISCUSSION: Besides branch retinal arteriolar occlusion, the angiopathy in Susac's syndrome may affect the optic disc vessels.
Asunto(s)
Disco Óptico/irrigación sanguínea , Oclusión de la Arteria Retiniana/etiología , Vasos Retinianos , Síndrome de Susac/complicaciones , Vasculitis/etiología , Adulto , Femenino , HumanosRESUMEN
CLINICAL CASE: The case is presented of a 16 year-old girl with unilateral congenital retinal macrovessel associated with peripheral telangiectasia and retinal ischaemia. DISCUSSION: Congenital retinal macrovessel is a rare finding. To the best of our knowledge this is the first report of this unusual presentation of congenital retinal macrovessel. After 21 months of follow up, visual acuity remained stable, and no complications developed.
Asunto(s)
Isquemia/complicaciones , Enfermedades de la Retina/complicaciones , Vasos Retinianos/anomalías , Telangiectasia/complicaciones , Adolescente , Femenino , HumanosRESUMEN
CASE REPORT: The case is presented of a 42 year-old man with episodes of unilateral uveitis in his right eye. Ophthalmic examination showed a granulomatous anterior uveitis with vitritis. Systemic investigations revealed non-nephrotic proteinuria and microhaematuria. A renal biopsy showed IgA nephropathy. DISCUSSION: Uveitis and glomerulonephritis may have common immunological pathogenesis. IgA nephropathy should be a differential diagnosis in patients with uveitis and nephropathy.
Asunto(s)
Glomerulonefritis por IGA/complicaciones , Uveítis/etiología , Adulto , Humanos , Masculino , Uveítis/diagnóstico por imagenAsunto(s)
Perforaciones de la Retina/complicaciones , Adherencias Tisulares/complicaciones , Hemorragia Vítrea/diagnóstico por imagen , Anciano , Coagulación con Plasma de Argón/efectos adversos , Humanos , Masculino , Perforaciones de la Retina/terapia , Adherencias Tisulares/diagnóstico por imagen , Adherencias Tisulares/etiología , Hemorragia Vítrea/etiologíaRESUMEN
CASE REPORT: The case is presented of a 39 year-old man with a combined hamartoma of the retina and retinal pigment epithelium, who experienced progressive visual loss and worsening of metamorphopsia. The patient underwent vitrectomy and epiretinal component peeling, with improvement in visual acuity, metamorphopsia, and retinal architecture, assessed by optical coherence tomography. DISCUSSION: Selected patients with combined hamartomas of the retina and retinal pigment epithelium may beneï¬t from surgical management.
Asunto(s)
Hamartoma/cirugía , Enfermedades de la Retina/cirugía , Epitelio Pigmentado de la Retina/cirugía , Vitrectomía/métodos , Adulto , Angiografía con Fluoresceína , Hamartoma/diagnóstico por imagen , Humanos , Masculino , Enfermedades de la Retina/diagnóstico por imagen , Epitelio Pigmentado de la Retina/diagnóstico por imagen , Tomografía de Coherencia ÓpticaAsunto(s)
Dexametasona/administración & dosificación , Retinopatía Diabética/tratamiento farmacológico , Glucocorticoides/administración & dosificación , Complicaciones Intraoperatorias/etiología , Edema Macular/tratamiento farmacológico , Implantes de Medicamentos , Humanos , Inyecciones Intravítreas , Masculino , Errores MédicosRESUMEN
CASE REPORT: A 36 year-old male with a recent HIV diagnosis, presented with loss of vision of his left eye. Ophthalmoscopy revealed a unilateral yellowish placoid lesion in the macula. After fluorescein angiography, optical coherence tomography, optical coherence tomography angiography, syphilis serology, and cerebrospinal ï¬uid results, he was diagnosed with neurosyphilis and syphilitic posterior placoid chorioretinitis. DISCUSSION: Acute syphilitic posterior placoid chorioretinitis is a rare ocular manifestation of syphilis. All patients with characteristic clinical and angiographic ï¬ndings of acute syphilitic posterior placoid chorioretinitis should be tested for a neurosyphilis and human immunodeï¬ciency virus co-infection. Early treatment with intravenous penicillin is usually effective with good visual results.
Asunto(s)
Coriorretinitis/etiología , Neurosífilis/diagnóstico , Adulto , Angiografía con Fluoresceína , Infecciones por VIH/complicaciones , Humanos , Masculino , Neurosífilis/complicaciones , Serodiagnóstico de la Sífilis , Tomografía de Coherencia ÓpticaRESUMEN
CASE REPORT: We present the case of a 55-year-old man with a non-small cell lung adenocarcinoma, who presented with choroidal metastasis. The patient showed a decrease in visual acuity. His evaluation revealed unilateral choroidal metastasis secondary to carcinoma of the lung. The patient received afatinib with complete regression of choroidal metastasis after one year follow-up. DISCUSSION: Choroidal metastasis may be the initial sign of lung cancer. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours. Afatinib was effective against choroidal metastasis of a lung adenocarcinoma with EFGR mutation.
Asunto(s)
Adenocarcinoma/secundario , Antineoplásicos/uso terapéutico , Carcinoma de Pulmón de Células no Pequeñas/secundario , Neoplasias de la Coroides/secundario , Neoplasias Pulmonares/diagnóstico , Inhibidores de Proteínas Quinasas/uso terapéutico , Quinazolinas/uso terapéutico , Adenocarcinoma/diagnóstico , Adenocarcinoma/tratamiento farmacológico , Adenocarcinoma/enzimología , Adenocarcinoma del Pulmón , Afatinib , Antineoplásicos/farmacología , Carcinoma de Pulmón de Células no Pequeñas/diagnóstico , Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico , Carcinoma de Pulmón de Células no Pequeñas/enzimología , Neoplasias de la Coroides/diagnóstico , Neoplasias de la Coroides/tratamiento farmacológico , Neoplasias de la Coroides/enzimología , Receptores ErbB/antagonistas & inhibidores , Humanos , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/enzimología , Masculino , Persona de Mediana Edad , Proteínas de Neoplasias/antagonistas & inhibidores , Inhibidores de Proteínas Quinasas/farmacología , Quinazolinas/farmacología , Inducción de Remisión , Transducción de Señal/efectos de los fármacosRESUMEN
CASE REPORT: The case is presented of a 49 year-old woman with an orbital mass originating from the rhinosinus. She had a history of Wegener's granulomatosis, refractory to both biological and immunosuppressive therapy. Clinical examination showed proptosis, diplopia, and restriction of ocular movements. DISCUSSION: Orbital mass resection was performed, due to its rapid growth, and lack of response to medical treatment.