RESUMEN
Leaves of Eugenia jambolana yielded the new flavonol, myricetin 3-O-(4"-acetyl)-alpha-L-rhamnopyranoside (1).
Asunto(s)
Flavonoides/química , Glicósidos/química , Myrtaceae , Fitoterapia , Humanos , Extractos Vegetales/química , Hojas de la PlantaRESUMEN
A partir do fracionamento em coluna de gel de sílica do extrato clorofórmico de Polygala paniculata (Polygalaceae), foram isolados 7-metóxi-8-(1',2'-epóxi-3'-metil-3'-butenil)-cumarina (1) e dois artefatos cumarínicos (2a-2b), formados a partir da abertura do anel epóxido de 1 durante o processo de isolamento. O tratamento de 1 com EtOH/SiO2, sob agitação e à temperatura ambiente durante 24 horas, resultou na formação dos respectivos artefatos: 7-metóxi-8-(1'-hidróxi-2-etóxi-3'-metil-3'-butenil)-cumarina (2a) e 7-metóxi-8-(1'-etóxi-2-hidróxi-3'-metil-3'-butenil)-cumarina (2b). As estruturas químicas desses compostos foram determinadas através da análise de seus dados espectrais, incluindo RMN bidimensional.
Fractionation of a chloroform extract of Polygala paniculata (Polygalaceae) on silica gel column chromatography yielded 7-methoxy-8-(1',2'-epoxy-3'-methyl-3'-butenyl)-coumarin (1) and two coumarinic artifacts (2a-2b). The reaction of 1 with EtOH/SiO2 at room temperature for 24 hours yielded 7-methoxy-8-(1'-hydroxy-2'-ethoxy-3'-methyl-3'-butenyl)-coumarin (2a) and 7-methoxy-8-(1'-ethoxy-2'-hydroxy-3'-methyl-3'-butenyl)-coumarin (2b). The structures have been determined by spectral data, including 2D NMR experiments.
RESUMEN
Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
Asunto(s)
Analgésicos/farmacología , Magnoliopsida/química , Sesquiterpenos/farmacología , Espectroscopía de Resonancia Magnética , Sesquiterpenos Policíclicos , Sesquiterpenos/química , Análisis EspectralRESUMEN
Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
Asunto(s)
Aciclovir/farmacología , Antivirales/farmacología , Flavonoides/farmacología , Herpesvirus Humano 1/efectos de los fármacos , Extractos Vegetales/farmacología , Vitex , Relación Dosis-Respuesta a Droga , Frutas/química , Humanos , Hojas de la Planta/química , Células Tumorales CultivadasRESUMEN
Two dihydrostyrylpyrones and a styrylpyrone were isolated from Polygala sabulosa, together with five known styrylpyrones. Their structures were established on the basis of spectral evidence as 4-methoxy-6-(11,12-methylenedioxy-14-methoxydihydrostyryl)-2-pyrone, 4-methoxy-6-(11,12-methylenedioxy-10,14-dimethoxydihydrostyryl)-2-pyrone, and 4-methoxy-6-(11,12-methylenedioxy-14-methoxystyryl)-2-pyrone.
Asunto(s)
Pironas/aislamiento & purificación , Rosales/química , Estructura Molecular , Pironas/química , Análisis EspectralRESUMEN
The present work describes the antinociceptive effects of some fractions and two pure compounds obtained from the Wedelia paludosa, a Brazilian medicinal plant employed in folk medicine against a variety of diseases, including dolorous pathologies. It was found that such fractions as well as kaurenoic acid and luteolin exhibit marked antinociceptive action in mice using acetic acid-induced writhing. They were more active than some well-known analgesic drugs, such as acetyl salicylic acid, acetaminophen, dipyrone and indomethacin. The results confirm our previous studies conducted with this plant, suggesting that different chemical constituents are responsible for the antinociceptive activity shown by the extracts and fractions prepared from W. paludosa.
Asunto(s)
Analgésicos no Narcóticos/farmacología , Antiinflamatorios no Esteroideos/farmacología , Medicina Tradicional , Dolor/tratamiento farmacológico , Plantas Medicinales , Abdomen , Acetaminofén/farmacología , Ácido Acético , Analgésicos no Narcóticos/administración & dosificación , Animales , Aspirina/farmacología , Brasil , Dipirona/farmacología , Diterpenos/aislamiento & purificación , Diterpenos/farmacología , Flavonoides/aislamiento & purificación , Flavonoides/farmacología , Indometacina/farmacología , Luteolina , Masculino , Ratones , Extractos Vegetales/farmacologíaRESUMEN
The isolation of the cyclopeptide alkaloids, adoutine-Y', discarine-B, discarine-E, and discarine-X, a new 14-membered cyclopeptide alkaloid from D. longispina, are reported. The structure of the new alkaloid was elucidated by spectroscopic methods and by chemical degradation.
Asunto(s)
Alcaloides/aislamiento & purificación , Péptidos Cíclicos/aislamiento & purificación , Plantas Medicinales/química , Alcaloides/química , Argentina , Brasil , Espectroscopía de Resonancia Magnética , Péptidos Cíclicos/química , Raíces de Plantas/química , Espectrofotometría Infrarroja , Espectrofotometría UltravioletaRESUMEN
A fraction obtained from the culture fluids of Pycnoporus sanguineus fungus was shown to contain a compound with biological activity against strains of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and members of the genus Streptococcus. The fraction was clearly more active on Gram-positive cocci than on Gram-negative bacilli.
Asunto(s)
Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Polyporaceae/metabolismo , Antibacterianos , Antiinfecciosos/aislamiento & purificación , Antiinfecciosos/metabolismo , Fraccionamiento Químico , Cromatografía en Capa Delgada , Medios de Cultivo , Escherichia coli/efectos de los fármacos , Klebsiella pneumoniae/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Pseudomonas aeruginosa/efectos de los fármacos , Salmonella typhi/efectos de los fármacos , Espectrofotometría Ultravioleta , Staphylococcus aureus/efectos de los fármacos , Streptococcus/efectos de los fármacosRESUMEN
The alkaloid and procyanidin composition of Uncaria sp. from eastern Peru, used in folk medicine was studied. Five alkaloids have been separated and identified as pteropodine, speciophylline, isopteropodine, uncarine F and isomytraphylline, all belonging to the oxindole group characteristic of the Rubiaceae. Moreover (--) epicatechin and four dimeric procyanidins A1, B1, B2 and B4 have been shown to constitute the polyphenolic fraction of the plant extract.
Asunto(s)
Alcaloides/aislamiento & purificación , Plantas Medicinales , Espectroscopía de Resonancia Magnética , Perú , Espectrofotometría InfrarrojaRESUMEN
The authors present the first observations on the isolation of two quinonoid compounds from Hyptis fructicosa Salzm ex Benth; Labiatae. The referred naturally compounds present antimicrobial and antineoplastic activity against Gram-positive microrganisms and mouse Erlich carcionama, respectivelly.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Plantas Medicinales , Quinonas/aislamiento & purificación , Animales , Antineoplásicos Fitogénicos/uso terapéutico , Bacterias/efectos de los fármacos , Carcinoma de Ehrlich/tratamiento farmacológico , Evaluación de Medicamentos , Farmacorresistencia Microbiana , Métodos , Ratones , Pruebas de Sensibilidad Microbiana , Trasplante de Neoplasias , Neoplasias Experimentales/tratamiento farmacológico , Fitoterapia , Extractos Vegetales/uso terapéutico , Quinonas/uso terapéutico , Sarcoma 180/tratamiento farmacológicoRESUMEN
In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.