RESUMEN
Baclofen is an agonist of peripheral and central B gamma-aminobutyric acid receptors, whose activation causes a myorelaxation and a powerfull depression of the central nervous system. Moreover, it has an action against addiction, in reducing craving. Commercialized since 1975 in France, to control muscle spasticity due to medullar affection or multiple sclerosis, it receives a temporary recommendation of use in march 2014, as a last-line adjuvant treatment in alcohol withdrawal. Beyond its therapeutic use, baclofen is involved in many self-induced intoxications. We report the case of a patient who develops, after a massive ingestion of baclofen (supposed dose ingested: 1 200 mg), a hypotonic and calm coma, requiring her admission in our intensive care unit, and then a status epilepticus.
Asunto(s)
Baclofeno/envenenamiento , Coma/inducido químicamente , Sobredosis de Droga/diagnóstico , Conducta Autodestructiva , Estado Epiléptico/inducido químicamente , Coma/complicaciones , Femenino , Francia , Humanos , Persona de Mediana Edad , Hipotonía Muscular/inducido químicamente , Hipotonía Muscular/complicaciones , Conducta Autodestructiva/complicaciones , Conducta Autodestructiva/diagnóstico , Estado Epiléptico/complicaciones , Síndrome de Abstinencia a Sustancias/complicacionesRESUMEN
Acute arsenic poisoning is a rare cause of suicide attempt. It causes a multiple organs failure caused by cardiogenic shock. We report the case of a patient admitted twelve hours after an ingestion of trioxide arsenic having survived thanks to a premature treatment.
Asunto(s)
Intoxicación por Arsénico , Óxidos/envenenamiento , Enfermedad Aguda , Adulto , Intoxicación por Arsénico/complicaciones , Intoxicación por Arsénico/diagnóstico , Trióxido de Arsénico , Arsenicales , Humanos , Masculino , Insuficiencia Multiorgánica/etiología , Intento de SuicidioRESUMEN
Falciparum malaria is a potentially deadly infectious disease, imposing a sure and fast biologic diagnosis, an early and efficient treatment. We report a case of severe imported Falciparium malaria who received artesunate, and we rewiew the different diagnostic methods of malaria as well as the clinico-biological characteristics of severe malaria. Recent data concerning malaria treatment are presented, as a pharmacokinetic study leaded during this case.
Asunto(s)
Antimaláricos/uso terapéutico , Artemisininas/uso terapéutico , Malaria Falciparum/diagnóstico , Malaria Falciparum/tratamiento farmacológico , Plasmodium falciparum/efectos de los fármacos , Antimaláricos/administración & dosificación , Artemisininas/administración & dosificación , Artesunato , República Centroafricana , Cromatografía de Afinidad , Humanos , Inyecciones Intravenosas , Malaria Falciparum/parasitología , Masculino , Persona de Mediana Edad , Plasmodium falciparum/aislamiento & purificación , Reacción en Cadena de la Polimerasa , Índice de Severidad de la Enfermedad , Viaje , Resultado del TratamientoRESUMEN
Sickle cell disease is the genetic disease most frequently detected at birth in France. The comprehension and knowledge of its pathophysiology allow to establish the principles of management for the drepanocytic patient, especially in the perioperative phase. In the light of recent recommendations published for anesthesia of a drepanocytic adult, this clinical case revealed allows to reexamine that subject, with a focus on biological aspects, which are transfusional strategy and antibioprophylaxy. The presented observation is a concrete feature of daily collaboration between clinician and biologist, which is an essential point of the ISO standard EN 15189 concerning laboratories' accreditation.
