RESUMEN
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Asunto(s)
Antígenos Helmínticos/sangre , Proteínas del Helminto/sangre , Hemocianinas/inmunología , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/diagnóstico , Enfermedad Aguda , Animales , Anticuerpos Antihelmínticos/inmunología , Biomarcadores/sangre , Enfermedad Crónica , Ensayo de Inmunoadsorción Enzimática , Hemocianinas/análisis , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Esquistosomiasis mansoni/sangre , Sensibilidad y EspecificidadRESUMEN
Specific IgG and IgM responses to soluble egg antigen (SEA) and keyhole limpet haemocyanin (KLH) were measured by ELISA in patients with acute and chronic schistosomiasis. The tests based upon IgM and IgG antibodies responses to KLH presented the best diagnostic discrimination, and can be used in conjunction with clinical and epidemiological data to the differential diagnosis of acute schistosomiasis.
Asunto(s)
Humanos , Animales , Antígenos Helmínticos , Schistosoma mansoni , Esquistosomiasis mansoni , Enfermedad Aguda , Anticuerpos Antihelmínticos , Biomarcadores , Enfermedad Crónica , Ensayo de Inmunoadsorción Enzimática , Inmunoglobulina G , Inmunoglobulina M , Sensibilidad y EspecificidadRESUMEN
The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma was evaluated in different clinical forms of human schistosomiasis. The mechanisms of immune regulation are apparently different in the various clinical stages of the disease, some of them being antigen specific
